Citation: DONG Zhen-Ming, WANG Jia-Na, ZHANG Qiang, WANG Yu. A Novel Fluorescent Probe Based on Schiff Base for Dual Sensing of Zn²⁺ and CN^-[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(3): 354-363. doi: 10.11895/j.issn.0253-3820.171144 shu

A Novel Fluorescent Probe Based on Schiff Base for Dual Sensing of Zn²⁺ and CN^-

College of Chemistry and Chemical Engineering in Shanxi University, Taiyuan 030000, China

Received Date: 3 August 2017
Revised Date: 29 November 2017

Fund Project: This work was supported by the Natural Science Foundation of Shanxi Province, China (No. 2013011040-6) and the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

A novel Schiff base probe 4'-hydroxy-3'-((2-pyridin-2-ylmethylimino) methyl)-4-biphenyl carbonitrile (HPBC) for dual sensing of Zn²⁺and CN^- was synthesized and characterized by various techniques such as UV-Vis, fluorescence, HRMS and NMR spectroscopy. HPBC was highly selective toward these two ions with different fluorescence signals in two different media. In EtOH-H₂O (2:3, V/V; HEPES, pH 7.4), HPBC selectively bound Zn²⁺ to form a 1:1 ligand/metal complex. Addition of Zn²⁺ to the solution of HPBC resulted in a blue shift (Δλ=15 nm) with a pronounced fluorescence enhancement at 468 nm, while there was no enhancement in the presence of other metal ions, especially Cd²⁺. HPBC displayed an "ON-OFF-ON" mode fluorescence change with alternative addition of Zn²⁺ and EDTA. Hence, HPBC is a reversible and reusable sensor for Zn²⁺. The dynamic range of the assay is linear up to 4.0 μmol/L Zn²⁺ ion and the limit of detection was 36.5 nmol/L, which was thousand fold lower than the WHO guideline (about 76 μmol/L) for drinking water. The fluorescence response of HPBC toward Zn²⁺ was pH-dependent, and the maximal signal was observed at near neutral pH values, which makes it suitable for application in physiological conditions. Cell imaging studies demonstrate that this sensor is capable of sensing Zn²⁺ in living cells. In DMSO-H₂O (3:7, V/V) medium, addition of cyanide ion to HPBC led to deprotonation of the phenol hydrogen, resulting in a color change from colorless to pale yellow and a significant fluorescence enhancement at 510 nm. The probe exhibited high selectivity and sensitivity for CN^- ion and the detection limit was 5.75×10^-7 mol/L. Finally, the use of a test strip of probe HPBC to detect cyanide was reported.
- Schiff-base,
- Fluorescent probe,
- Zinc ion,
- Cyanide ion,
- Recognition and determination
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沈阳化工大学材料科学与工程学院沈阳 110142

A Novel Fluorescent Probe Based on Schiff Base for Dual Sensing of Zn2+ and CN-

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通讯作者: 陈斌, bchen63@163.com

A Novel Fluorescent Probe Based on Schiff Base for Dual Sensing of Zn²⁺ and CN^-