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Citation: CHEN Si-Yi, GUO Xin-Yan, ZHU Wei, WANG Na, WANG Ying, KONG De-Yang. Development of Mass Spectrum Fingerprint Extraction Technology for Antibiotics in Surface Water[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(2): 178-187. doi: 10.11895/j.issn.0253-3820.170302 shu

Development of Mass Spectrum Fingerprint Extraction Technology for Antibiotics in Surface Water

CHEN Si-Yi ^1,2, ,
GUO Xin-Yan ² ,
ZHU Wei ² ,
WANG Na ² ,
WANG Ying ¹ ,
KONG De-Yang ²

1.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;
2.
Nanjing Institute of Environmental Sciences, Ministry of Environmental Protection of China, Nanjing 210042, China

Received Date: 11 May 2017
Revised Date: 1 November 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21507037).

An extract method for the fingerprint feature of 49 kinds of antibiotics belonging to multiple classes in surface water was developed. Water sample was purified and concentrated by tandem dual column (MAX and HLB), and qualitatively and quantitatively analyzed by ultra-high performance liquid chromatography-tandem mass spectrometric (SPE-UPLC-MS/MS) under multiple reaction monitoring (MRM) mode. The pretreatment was optimized in types of SPE column, loading pH, eluent and redissolution for multiclass antibiotics. The results showed that the linearity of target antibiotics was good in the range of 0.001-0.5 μg/mL (0.01-5 μg/mL for streptomycin). The recoveries were from 51.7% to 94.8%, and the relative standard deviations (RSDs) ranged from 2.19% to 9.67%. The limits of detection (LOD, S/N=3) were 0.01-3.23 μg/L and 0.05-3.43 μg/L and the limits of quantification (LOQ, S/N=10) were 0.04-10.8 μg/L and 0.17-11.4 μg/L in different redissolve solutions. This method was applied to the determination of antibiotics in water samples from 9 sites of Qinhuai River and Xuanwu Lake.
- Solid phase extraction,
- Ultra high performance liquid chromatography-tandem mass spectrometry,
- Antibiotic,
- Surface water
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