Citation: QIN Shi-Ya, CHEN Nan-Di, WANG Qing, HUANG Jin, HE Xiao-Xiao, LIU Jian-Bo, GUO Qiu-Ping, YANG Xiao-Hai, WANG Ke-Min. Application of Nucleic Acid Aptamers in Polypeptides Researches[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(12): 1795-1803. doi: 10.11895/j.issn.0253-3820.170272 shu

Application of Nucleic Acid Aptamers in Polypeptides Researches

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China

Corresponding author: YANG Xiao-Hai, yangxiaohai@hnu.edu.cn WANG Ke-Min, kmwang@hnu.edu.cn
Received Date: 2 May 2017
Accepted Date: 3 September 2017

Fund Project: the National Natural Science Foundation of China 21190040the National Natural Science Foundation of China 21521063This work was supported by the National Natural Science Foundation of China (Nos. 21675047, 21375034, 21190040, 21521063)the National Natural Science Foundation of China 21375034the National Natural Science Foundation of China 21675047

Figures(4)

Polypeptides play a vital role in physiological processes of life. The pharmacological and medical value of polypeptides has attracted the attention of researchers in recent years. Aptamers are short, single stranded DNA or RNA which developed by an in vitro process called systematic evolution of ligands by exponential enrichment (SELEX). Aptamers can bind targets with high affinity and specificity. Hence, aptamer is also called "chemical antibody" or "chemist's antibody". To date, there are two main application aspects for polypeptides-targeted aptamers. First, aptamer can be used as specific affinitive elements based on their ability of recognition, which would be applied to polypeptides detection or imaging. The other one is that aptamer can also be used as antagonists based on their ability of inhibiting, which can restrict the activity of polypeptides and block the downstream signaling pathways in vivo, thus can be used to treat the disease associated with polypeptides. In this review, we summarize the numbers of polypeptides-targeted aptamers and the related applications in vitro and in vivo. Current issues and development trends throughout the screening, characterizing and applying of polypeptides-targeted aptamers are also discussed.
- Polypeptides,
- Aptamers,
- Analytical methods,
- Biological imaging,
- Antagonists,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142