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Citation: ZHAO Fang, ZHAO Xue-Qiu, CHANG Qing, WANG Shu-Hui, DU Yao, YANG Li-Juan. Study on Inclusion Behavior and Properties of Cordycepin with Hydroxypropyl-β-Cyclodextrin[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(10): 1547-1555. doi: 10.11895/j.issn.0253-3820.170269 shu

Study on Inclusion Behavior and Properties of Cordycepin with Hydroxypropyl-β-Cyclodextrin

ZHAO Fang ^1, ,
ZHAO Xue-Qiu ¹ ,
CHANG Qing ¹ ,
WANG Shu-Hui ¹ ,
DU Yao ¹ ,
YANG Li-Juan ^1,2

1.
School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China;2 Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Kunming 650500, China

Received Date: 1 May 2017
Revised Date: 21 July 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21762051, 21562048, 21162042) and Innovative Team of Yunnan Minzu University.

The inclusion complex of cordycepin (COR) with hydroxypropyl-β-cyclodextrin (HPβCD) was prepared by the method of saturated solution. The inclusion of HPβCD with COR in aqueous solution was studied by UV-vis spectroscopy, and the inclusion ratio of COR/HPβCD complex was determined with the Job plots. The COR/HPβCD complex was characterized and determined by means of ¹H NMR and 2D NMR, differential scanning calorimetry (DSC), thermogravimetric analysis (TG), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). The results showed that the COR/HPβCD complex ratio was 1:1 and the water solubility and stability of COR were obviously increased in the inclusion complex with HPβCD. The COR/HPβCD complex will be potentially useful for its medical application.
- Cordycepin,
- Hydroxypropyl-β-cyclodextrin,
- Inclusion complex,
- Solubility,
- Stability
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