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Citation: SUN Wei, SHE Meng-Yao, MA Si-Yue, CHEN Jiao, SHI Zhen, LI Jian-Li. Study on Inclusion Behavior of Carbendazim with Cyclodextrins[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(2): 246-253. doi: 10.11895/j.issn.0253-3820.170031 shu

Study on Inclusion Behavior of Carbendazim with Cyclodextrins

Key Laboratory of Synthetic and Natural Functional Molecular Chemistry, Ministry of Education, College of Chemistry & Material Science, Northwest University, Xi'an 710127

Received Date: 13 April 2017
Revised Date: 13 October 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21572177, 21673173, J1210057) and the Natural Science Foundation of Shaanxi Province, China (Nos. 2015J003, 2016JZ004).

Hydrophobic medicine carbendazim, come into inclusion compounds with β-cyclodextrin (β-CD), 2-hydroxypropyl-β-CD (2-Hp-β-CD) and 2,6-dimethyl-β-CD (Me-β-CD), were made by solvent method. By investigating the inclusion behaviors of these three cyclodextrins combined with carbendazim using 1H NMR, 2D rotating frame overhause effect spectroscopy (ROESY) and diffusion ordered spectroscopy, the possible ways of combinations and the recognition ratio of this three inclusion compounds, D_β-CD=2.516×10^-10 m²/s, D_2-Hp-β-CD=1.676×10^-10 m²/s, D_Me-β-CD=2.046×10^-10 m²/s, were obtained. According to X-ray power diffraction, thermogravimetric analysis, infrared spectroscopy and scanning electron spectroscopy characterization, it was found that the characteristic diffraction peaks changed after carbendazim and cyclodextrin formed into inclusion compounds, and the characteristic diffraction peak of carbendazim at 10.4°, 21.2°, 25.8°, 31.5°(2θ) lost or disappear. The pyrolysis temperature of carbendazim was 197.5℃, and would be higher than 260℃ after it formed inclusion complex. The infrared spectrum also showed that the oscillation peaks of inner cyclodextrin cavum apparently reduced after carbendazim combined, which demonstrated that the position of water molecules inside cyclodextrin cavum were occupied by the carbendazim molecules. With the help of SEM, the appearances of inclusion were different from a single carbendazim molecule, which manifested a new structure appeared.
- Carbendazim,
- Cyclodextrins,
- Nuclear magnetic resonance,
- Inclusion
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