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Citation: WANG Xiao-Fei, JIANG Shou-Fang, ZHANG Wei-Bing, ZHANG Ling-Yi, LIU Ying, DU Xiao-Ynu, ZHANG Jie, ZHANG Wei-Jie. Study on Reproductive Toxicity of Fine Particulate Matter by Metabolomics[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(5): 633-640. doi: 10.11895/j.issn.0253-3820.170020 shu

Study on Reproductive Toxicity of Fine Particulate Matter by Metabolomics

1.
Shanghai Key laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;
2.
Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China;
3.
Ningbo Urban Environment Observation and Research Station-NUEORS, Chinese Academy of Sciences, Ningbo 315800, China;
4.
School of Public Health, North China University of Science and Technology, Tangshan 063000, China

Received Date: 11 January 2017
Revised Date: 10 February 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21407143, 21677141)

Air born fine particulate matter (PM2.5) pollution is a serious environmental problem, and it is very important to study the toxicity effect and mechanism of PM2.5. In this study, a liquid chromatography-mass spectrometric (LC-MS) method on the basis of metabolomics technique was developed to investigate the metabolic disruption effect and reproductive toxicity mechanism of PM2.5 on rat testis. The profile of aqueous and organic testis metabolic extracts were acquired, and then analyzed by partial least square-discriminant analysis and nonparametric test. The results showed that control group and treatment group were clearly discriminated in the scoring plot of PLS-DA models, indicating PM2.5 treatment induced significant difference in testis metabolome. A total of 56 differential metabolites were identified, and further pathway analysis suggested that PM2.5 exposure induced amino acid and nucleotide metabolism disorder, steroid hormone metabolism imbalance and abnormal lipid metabolism. These important pathways may be the key molecular events in the PM2.5 reproductive toxicity.
- Metabolomics,
- Fine particulate matter,
- Testis,
- Reproductive toxicity,
- Liquid chromatography-mass spectrometry
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