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Citation: SHEN Su-Su, LIANG Da-Peng, CHEN Huan-Wen, SU Rui. Determination of Hazard Compounds in Cigarette Smoke by High-Resolution Orbitrap Mass Spectrometry Combined with Nanofiber Membrane Extraction[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(2): 253-260. doi: 10.11895/j.issn.0253-3820.160761 shu

Determination of Hazard Compounds in Cigarette Smoke by High-Resolution Orbitrap Mass Spectrometry Combined with Nanofiber Membrane Extraction

1.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China;
2.
Changchun University of Chinese Medicine, Changchun 130117, China;
3.
College of Environment and Resources, Jilin University, Changchun 130012, China;
4.
Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang 330013, China

Received Date: 14 October 2016
Revised Date: 5 December 2016

A new method was proposed for analysis of the organic compounds in cigarette smoke by high resolution Orbitrap mass spectrometry based on polyacrylonitrile-silica (PAN-SiO₂) nanofiber membrane extraction and methanol elution. Hydrophobic PAN-SiO₂ nanofiber membrane which was used to enrich small molecular organic compounds in cigarette smoke was prepared by the technology of electrospinning. Several parameters including the concentrations of PAN and SiO₂ nanopartical, elecrospining voltage, needle aperture and flow rate of spinning solution were optimized. Under the optimal conditions, a PAN-SiO₂ nanofiber membrane with good adsorption performance and great physical strength was obtained. A total of 21 compounds including acetone, styrene, acrolein, isoprene, and acrylonitrile were identified by analyzing the cigarette smoke with Orbitrap MS spectrometry in the positive ion mode. Six organic acids including salicylic acid, malic acid and lactic acid were detected in negative ion mode. The limits of detection and quantification for nicotine were 0.071 ng/L and 0.236 ng/L, respectively.
- Polyacrylonitrile-silica nanofiber membranes,
- High resolution mass spectrometry,
- Cigarette smoke,
- Hazard organic compounds
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