Citation: ZHANG Tao, LI Zhi, SUN Quan-Hong, MA Nan. Synthesis and Characterization of AgInS₂ Quantum Dots and Detection of Tumor Cells by Folic Acid-Conjugated AgInS₂ Quantum Dots[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(12): 1840-1845. doi: 10.11895/j.issn.0253-3820.160268 shu

Synthesis and Characterization of AgInS₂ Quantum Dots and Detection of Tumor Cells by Folic Acid-Conjugated AgInS₂ Quantum Dots

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Received Date: 7 April 2016
Revised Date: 5 September 2016

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21175147, 91313302, 21473093) and the National High Technology Research and Development Program of China (No.2014AA020518).

The low-toxic AgInS₂ QDs were synthesized in aqueous phase and their absorption and photoluminescence spectra were characterized. The low-toxic AgInS₂ QDs had a broad absorption spectra and the emission peak was around 700 nm. The composition elements were analyzed via ICP-OES. High resolution transmission electron microscopy (RTEM) was used to characterize the size and distribution of the synthesized low-toxic AgInS₂ QDs. Then, the photostability and cytotoxicity of AgInS₂ QDs were compared with the traditional CdTe QDs. The results showed that the AgInS₂ QDs were much more stable than CdTe under the irradiation of a 405-nm laser. Without heavy metal elements, the cytotoxicity of AgInS₂ QDs was much lower than CdTe QDs, which meant it was more likely to be applied in the biological field. Folic acid (FA) was known as an effective tumor targeting molecule. When AgInS₂ QDs were combined with folic acid, the FA-AgInS₂ QDs could be used to distinguish tumor cells between the normal cells and cancer cells. The results showed the AgInS₂ QDs possessed great application prospects in the in vivo tumor detection.
- Quantum dots,
- Low toxicity,
- Spectrum,
- Tumor,
- Imaging
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Synthesis and Characterization of AgInS₂ Quantum Dots and Detection of Tumor Cells by Folic Acid-Conjugated AgInS₂ Quantum Dots