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Citation: ZHAO Xiao-Juan, LI Yi-Qin, BAI Wei-Dong, LIU Gong-Liang. Highly Sensitive Electrochemical Determination of Cephalexin Residue in Chicken Based on Hydrolysis Reaction Promoted by Cu[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(12): 1927-1933. doi: 10.11895/j.issn.0253-3820.160260 shu

Highly Sensitive Electrochemical Determination of Cephalexin Residue in Chicken Based on Hydrolysis Reaction Promoted by Cu

College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China

Received Date: 5 April 2016
Revised Date: 29 August 2016

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21005091).

A sensitive electrochemical modified electrode (Cys/AuNPs/AuE) to Cu was fabricated by immobilizing gold nanoparticles (AuNPs) and L-cysteine (Cys) on the surface of gold electrode (AuE). Cephalexin was hydrolyzed in the presence of Cu, then the cephalexin concentration was obtained indirectly by using square wave voltammetry to detect the remaining Cu in hydrolysate. The modified conditions of AuE and hydrolytic conditions of cephalexin were optimized. When cephalexin was hydrolyzed in HAc-NaAc buffer solution (pH 4.5) with Cu at 100℃ for 25 min, the remaining Cu in hydrolysate showed good electrochemical response on Cys/AuNPs/AuE. The difference of reductive peak currents had good linear relationships with cephalexin concentration in the range of 0.0058-0.12 μmol/L and 0.12-2.9 μmol/L, respectively. The detection limit was 1.9 nmol/L based on the signal to noise ratio of 3. The proposed method was applied to detect cephalexin residue in chicken sample. The results showed that this method was simple, rapid, high sensitive, and suitable for the determination of cephalexin residue in chicken and other food samples.
- Cefalexin,
- Hydrolysis,
- Electrochemical sensor,
- Metal nanoparticles,
- Voltammetry
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