Citation: ZHANG Sen, LIU Lu-Juan, CHEN Huan, HOU Hong-Wei, HU Qing-Yuan. Progress on Molecular Mechanism of Phosphorylation/Dephosphorylation and Detection Technology of γH2AX[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(8): 1291-1299. doi: 10.11895/j.issn.0253-3820.160054 shu

Progress on Molecular Mechanism of Phosphorylation/Dephosphorylation and Detection Technology of γH2AX

1.
China National Tobacco Quality Supervision & Test Center, Zhengzhou 450001, China;
2.
Institute of Applied Technology, Hefei Institutes of physical Science, Chinese Academy of Sciences, Hefei 230031, China

Received Date: 20 January 2016
Revised Date: 19 May 2016

Fund Project: This workwas supported by the National Natural Science Foundation of China (No. 21347002)

Figures(5)

Since γH2AX was firstly found in 1998, it has been one of the most important scientific topics and research tools in the related scientific fields. At present, a series of advanced testing methods and analytical technologies have been developed, which exhibited a quite attractive application prospect in the area of life science and medical science. This paper reviewed the latest progress about γH2AX in terms of molecular mechanism of phosphorylation/dephosphorylation, development of testing technologies, and the related applications.
- γH2AX,
- Phosphorylation,
- Immunofluorescence technology,
- Toxicity evaluation,
- Review
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
34. [34]
35. [35]
36. [36]
37. [37]
38. [38]
39. [39]
40. [40]
41. [41]
42. [42]
43. [43]
44. [44]
45. [45]
46. [46]
47. [47]
48. [48]
49. [49]
50. [50]
51. [51]
52. [52]
53. [53]
54. [54]
55. [55]
56. [56]
57. [57]
58. [58]
59. [59]
60. [60]
61. [61]
62. [62]
63. [63]
64. [64]
1. [1]
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1.
沈阳化工大学材料科学与工程学院沈阳 110142