Citation: TIAN Cai-Yan, DING Xue-Lu, YIN Jin-Wei, DUAN Yi-Xiang. Preliminary Study of Microfabricated Glow Discharge Plasma Used for Mass Spectrometry Imaging[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(1): 8-12. doi: 10.11895/j.issn.0253-3820.150787 shu

Preliminary Study of Microfabricated Glow Discharge Plasma Used for Mass Spectrometry Imaging

TIAN Cai-Yan ^1,2 ,
DING Xue-Lu ^1,2 ,
YIN Jin-Wei ^1,2 ,
DUAN Yi-Xiang ^1,2,3

1.
¹ College of Life Science, Sichuan University, Chengdu 610064, China;
2.
² Research Center of Analytical Instrumentation, Sichuan University, Chengdu 610064, China;
3.
³ Key Laboratory of Bio-resource and Eco-environment Ministry of Education, Sichuan University, Chengdu 610064, China

Received Date: 10 October 2015
Available Online: 4 November 2015

To evaluate the ability of microfabricated glow discharge plasma (MFGDP) as ion source used for mass spectrometry imaging, the different handwritings with urea added were analyzed, and the spatial distribution of stearic acid and the ramification of quercetin in a slice of winter jujube were explored. The MFGDP was independently researched and developed by our lab, and acted as ion source to absorb and ionize the sample. The mass spectra of the excited sample ions entered into mass spectrometer were converted into corresponding image by special software. The results showed that the MFGDP source was feasible and valuable for mass spectrometry imaging. The method proposed here has remarkable features such as simple device, easy operation, low temperature plasma and time saving (<20 min) and it could be used to locate the distribution of the different substances in a sample. The factors influenced the definition of image were discussed and the experimental conditions were optimized, and the resolution was about 300 μm under the optimum conditions. The technology can distinguish different handwritings according to the
- Micro-fabricated glow discharge plasma,
- Mass spectrometry,
- Scan,
- Imaging
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