Citation: CHEN Wei, CHEN Yu-Quan. Fabrication of Flexible Continuous Glucose Monitoring Sensor by Non-Patterning Method[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(4): 654-659. doi: 10.11895/j.issn.0253-3820.150542 shu

Fabrication of Flexible Continuous Glucose Monitoring Sensor by Non-Patterning Method

CHEN Wei ,
CHEN Yu-Quan ^,

1.
College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China

Corresponding author: CHEN Yu-Quan,
Received Date: 7 July 2015
Available Online: 29 February 2016

A tight gold layer was electroless plated on polyimide film coated with polydopamine. A polyurethane coated flexible glucose sensor was developed based on this two side gold layer structure, wherein the platinum black plating side was used as reference-counter electrode and another side that was successively modified by platinum black layer, Nafion/carbon nanotube(CNT) layer and glucose oxidase(Gox) layer as working electrode. The morphology of each layer and its influence on glucose sensing performance were investigated. The glucose biosensor showed a linear range from 2.0 to 32.0 mmol/L and the sensitivity was 25μA·(mmol/L)^-1·cm^-2 at low potential of 0.3 V, with a detection limit of 0.05 mmol/L(S/N=3). The biosensor could avoid the commonly coexisted interference and exhibited high stability in the continuous subcutaneous glucose monitoring.
- Surface metallization,
- Flexible sensor,
- Continuous glucose monitoring,
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