Citation: YANG Shao-Ming, DING Su-You, CHEN Yan-Sheng, ZHANG Xiao-Rong, ZHENG Yue, ZHENG Long-Zhen. Study of Impedance Aptasensor Based on Layered Double Hydroxides-Gold Nanoparticles[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(1): 110-116. doi: 10.11895/j.issn.0253-3820.150316 shu

Study of Impedance Aptasensor Based on Layered Double Hydroxides-Gold Nanoparticles

1.
Department of Chemistry and Chemical Engineering, School of Sciences, East China Jiaotong University, Nanchang 330013, China

Corresponding author: YANG Shao-Ming,
Received Date: 19 April 2015
Available Online: 19 July 2015
Fund Project: 本文系国家自然科学基金资助项目(Nos.21465012,21065004) (Nos.21465012,21065004)

A highly sensitive impedance aptamer biosensor was fabricated on the glassy carbon electrode surface by one-step electrochemical deposition synthesis of cobalt aluminium layered double hydroxides-gold nanoparticles (CoAl LDH-GNPs) composite nanomaterials, which were used as the immobilization matrix for aptamer. The composite nanomaterials of CoAl LDH-GNPs were characterized with scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS). The electrode assembly process was monitored by the cyclic voltammetry and electrochemical impedance spectroscopy, the performance of sensor was studied by electrochemical impedance spectroscopy. The sensor fabricated by LDH-GNPs nanomaterials showed a linear relationship to thrombin from 1.0 ng/L to 100.0 μg/L with a linear correlation coefficient R=0.995 and a detection limit of 0.3 ng/L(S/N=3).
- Layered double hydroxides composite nanomaterials,
- Impedance,
- Aptasensor,
- Thrombin
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