Citation: SHEN Feng, LI Yi, LIU Zhao-Miao, CAO Ren-Tuo, WANG Gui-Ren. Advances in Micro-Droplets Coalescence Using Microfluidics[J]. Chinese Journal of Analytical Chemistry, ;2015, 43(12): 1942-1954. doi: 10.11895/j.issn.0253-3820.100509 shu

Advances in Micro-Droplets Coalescence Using Microfluidics

SHEN Feng ^1,2 ,
LI Yi ¹ ,
LIU Zhao-Miao ^1,, ,
CAO Ren-Tuo ¹ ,
WANG Gui-Ren ²

1.
¹ College of Mechanical Engineering and Applied Electronics Technology, Beijing University of Technology, Beijing 100124, China;

Corresponding author: LIU Zhao-Miao,
Received Date: 22 June 2015
Available Online: 16 August 2015
Fund Project: 本文系北京市自然科学基金(No.7152012) (No.7152012)国家留学基金(No.201406545031) (No.201406545031)北京工业大学"日新人才"培养计划项目(No.2015-RX-L02)资助 (No.2015-RX-L02)

Recently, with the development of lab-on-a-chip researches, the use of microfluidics to precisely control the droplet behavior in microchannel has received more and more research attention. This article introduces the basic theory and mechanism of the droplets coalescence, and then carefully reviews the passive methods of droplets coalescence used in current researches by changing microchannel geometry and adding surfactants. The active methods to trigger droplet fusion such as applied electric field, magnetic fields, temperature gradients, surface acoustic wave and focused lasers are also introduced briefly. We also introduce the fluid dynamics of the droplets coalescence and forecast its progress at last to provide useful guidance for microfluidic devices design and wide use of the drop-based microfluidics.
- Microfluidics,
- Droplets coalescence,
- Microchannel,
- Lab-on-a-chip,
- Review
1. [1]
  1 FANG Zhao-Lun. Microfluidic Chip. Beijing:Science Press, 2003:23-78 方肇伦. 微流控分析芯片. 北京:科学出版社, 2003:23-78
2. [2]
  2 LI Zhan-Hua, WU Jian-Kang, HU Guo-Qing, HU Guo-Hui. Fluid Flow in Microfluidic Chips. Beijing:Science Press, 2012:121-138 李战华, 吴健康, 胡国庆, 胡国辉. 微流控芯片中的流体流动. 北京:科学出版社, 2012:121-138
3. [3]
  3 Stone H A, Stroock A D, Ajdari A. Annu. Rev. Fluid. Mech., 2004, 36(1):381-411
4. [4]
  4 LIN Bing-Cheng, QIN Jian-Hua. Graphic Laboratory on a Microfluidic Chip. Beijing:Science Press, 2008:2-86 林炳承, 秦建华. 图解微流控芯片实验室. 北京:科学出版社, 2008:2-86
5. [5]
  5 Whitesides G M. Nature, 2006, 442(7101):368-373
6. [6]
  6 Joanicot M, Ajdari A. Science, 2005, 309(5736):887-888
7. [7]
  7 Utada A S, Lorenceau E, Link D R, Kaplan P D, Stone H A, Weitz D A. Science, 2005, 308(5721):537-541
8. [8]
  8 Charles N B, Francois G, Remi D. Lab Chip, 2010, 10(16):2032-2045
9. [9]
  9 CHEN Jiu-Sheng, JIANG Jia-Huan. Chinese J. Anal. Chem., 2012, 40(8):1293-1300 陈九生, 蒋稼欢. 分析化学, 2012, 40(8):1293-1300
10. [10]
  10 ZHANG Kai, HU Ping, LIANG Qiong-Lin, LUO Guo-An. Chinese J. Anal. Chem., 2008, 36(4):556-562 张凯, 胡坪, 梁琼麟, 罗国安. 分析化学, 2008, 36(4):556-562
11. [11]
  11 SONG Wen-Bin, DONG Chao-Qing, REN Ji-Cun. J. Anal. Sci., 2011, 27(1):106-112 宋文斌, 董朝青, 任吉存. 分析科学学报, 2011, 27(1):106-112
12. [12]
  12 DENG Nan-Nan, WANG Wei, JU Xiao-Jie, XIE Rui, LIU Zhuang, CHU Liang-Yin. Scientia Sinica Chimica, 2015, 45(1):7-15 邓楠楠, 汪伟, 巨晓洁, 谢锐, 刘壮, 褚良银. 中国科学:化学, 2015, 45(1):7-15
13. [13]
  13 XIAO Zhi-Liang, ZHANG Bo. Chinese Journal of Chromatography, 2011, 29(10):949-956 肖志良, 张博. 色谱, 2011, 29(10):949-956
14. [14]
  14 He M Y, Edgar J S, Jeffries G D M, Lorenz R M, Shelby J P, Chiu D T. Anal. Chem., 2005, 77(6):1539-1544
15. [15]
  15 Demirci U, Montesano G. Lab Chip, 2007, 7(9):1139-1145
16. [16]
  16 Funfak A, Brosing A, Brand M, Kohler J M. Lab Chip, 2007, 7(9):1132-1138
17. [17]
  17 Shi W, Qin J, Ye N, Lin B. Lab Chip, 2008, 8(9):1432-1435
18. [18]
  18 Hansen C L, Classen S, Berger J M, Quake S R. J. Am. Chem. Soc., 2006, 128(10):3142-3143
19. [19]
  19 Li L, Mustafi D, Fu Q, Tereshko V, Chen D L, Tice J D, Ismagilov R F. Pro. Natl. Acad. Sci.USA, 2006, 103(51):19243-19248
20. [20]
  20 Hung L H, Choi K M, Tseng W Y, Tan Y C, Shea K J, Lee A P. Lab Chip, 2006, 62(2):174-178
21. [21]
  21 Shestopalov I, Tice J D, Ismagilov R F. Lab Chip, 2004, 4(4):316-321
22. [22]
  22 Steinbacher J L, Moy R W Y, Price K E, Cummings M A, Roychowdhury C, Buffy J J, Olbricht W L, Haaf M, McQuade D T. J. Am. Chem. Soc., 2006, 128(29):9442-9447
23. [23]
  23 Schabas G, Wang C W, Oskooei A, Yusuf H, Moffitt M G, Sinton D. Langmuir, 2008, 24(19):10596-10603
24. [24]
  24 Niu X, Gielen F, Edel J B, deMello A J. Nat. Chem., 2011, 3(6):437-442
25. [25]
  25 Brouzes E, Medkova M, Savenelli N, Marran D, Twardowski M, Hutchison J B, Rothberg J M, Link D R, Perrimon N, Samuels M L. Proc. Natl. Acad. Sci. USA, 2009, 106(34), 14195-14200
26. [26]
  26 CHEN Xiao-Dong, HU Guo-Qing. Advances in Mechanics, 2015, 45:201503 陈晓东, 胡国庆. 力学进展, 2015, 45:201503
27. [27]
  27 Simon M G, Lee A P. Microdroplet Technology. New York:Springer, 2012:23-50
28. [28]
  28 Zagnoni M, Cooper J M. Lab Chip, 2009, 9(18):2652-2658
29. [29]
  29 García A A, Egatz-Gómez A, Lindsay S A, Dominguez-Garcia P, Melle S. J. Magn. Magn. Mater., 2007, 311(1):238-243
30. [30]
  30 Köhler J M, Henkel T, Grodrian A, Kirner T, Roth M, Martin K, Metze J. Chem. Eng. J., 2004, 101(1-3):201-216
31. [31]
  31 Lin S C S, Mao X, Huang T J. Lab Chip, 2012, 12(16):2766-2770
32. [32]
  32 ZHANG Yue, GAO Ting, HU Chu, HUANG Chang, YU Yi-Qing, ZHANG An-Liang. Piezoelectrics & Acoustooptics, 2012, 34(5):676-679 张悦, 高挺, 胡楚, 黄昶, 尉一卿, 章安良. 压电与声光, 2012, 34(5):676-679
33. [33]
  33 Baroud C N, de Saint Vincent M R, Delville J P. Lab Chip, 2007, 7(8):1029-1033
34. [34]
  34 DONG Li-Chun, WU Ji-Zhou, REN Gui-Xiang, TAN Shi-Yu, HUANG Da-Fu, LI Wen-Ping, HUANG Shao-Jian. Journal of Chongqing University, 2011, 34(1):134-139 董立春, 吴纪周, 任桂香, 谭世语, 黄大富, 李文平, 黄少建. 重庆大学学报, 2011, 34(1):134-139
35. [35]
  35 Wu P, Luo Z F, Liu Z F, Li Z D, Chen C, Feng L L, He L Q. Chinese J. Chem. Eng., 2015, 23(1):7-14
36. [36]
  36 WANG Jia-Nan, WANG Jia-Jun, FENG Lian-Fang, GU Xue-Ping. J. Chem. Eng. Chin. Univ., 2014, 28(2):218-222 王佳男, 王嘉骏, 冯连芳, 顾雪萍. 高校化学工程学报, 2014, 28(2):218-222
37. [37]
  37 Baret J C. Lab Chip, 2012, 12(3):422-433
38. [38]
  38 Dai B, Leal L. Phys. Fluids, 2008, 20(4):1569-1579
39. [39]
  39 Gunes D Z, Clain X, Breton O, Mayor G, Burbidge A S. J. Colloid Interface Sci., 2010, 343(1):79-86
40. [40]
  40 Chesters A K. Chem. Eng. Res. Des., 1991, 69(4):259-270
41. [41]
  41 Christopher G F, Bergstein J, End N B, Poon M, Nguyen C, Anna S L. Lab Chip, 2009, 9:1102-1109
42. [42]
  42 Borrell M, Yoon Y, Leal L G. Phys. Fluids, 2004, 16(11):3945-3954
43. [43]
  43 Klaseboer E, Chevaillier J P, Gourdon C, Masbernaty O. J. Colloid Interface Sci., 2000, 229(1):472-485
44. [44]
  44 Hu Y T, Pine D J, Leal L G. Phys. Fluids, 2000, 12(3):484-489
45. [45]
  45 Baldessari F, Homsy G M, Leal L G. J. Colloid Interface Sci., 2007, 307(1):188-202
46. [46]
  46 Yang H, Park C C, Hu Y T, Leal L G. Phys. Fluids, 2001, 13(5):1087-1106
47. [47]
  47 Yoon Y, Borrell M, Park C C, Leal L G. J. Fluid Mech., 2005, 525(2):355-379
48. [48]
  48 Baldessari F, Leal L G. Phys. Fluids, 2006, 18(1):302-309
49. [49]
  49 Rother M A, Davis R H. Phys. Fluids, 2001, 13(5):1178-1190
50. [50]
  50 Li S Z, Chen R, Wang H, Liao Q, Zhu X, Wang Z B. Appl. Therm. Eng., 2014, 64(1-2):129-138
51. [51]
  51 Burkhart B E, Gopalkrishnan P V, Hudson S D, Jamieson A M, Rother M A, Davis R H. Phys. Rev. Lett., 2001, 87(9):098304
52. [52]
  52 Guido S, Simeone M. J. Fluid Mech., 1998, 357(2):1-20
53. [53]
  53 Aryafar H, Kavehpour H P. Phys. Fluids, 2006, 18(7):3453-3475
54. [54]
  54 Mohamed-Kassim Z, Longmire E K. Phys. Fluids, 2003, 15(11):3263-3273
55. [55]
  55 Xu B, Nguyen N T,Wong T N. Micro and Nanosystems, 2011, 3:131-136
56. [56]
  56 Tan Y C, Fisher J S, Lee A L, Cristini V, Lee A P. Lab Chip, 2004, 4(4):292-298
57. [57]
  57 Gunes D Z, Bercy M, Watzke B, Breton O, Burbidge A S. Soft Matter, 2013, 9(31):7526-7537
58. [58]
  58 Tan Y C, Ho Y L, Lee A P. Microfluid. Nanofluid., 2007, 3(4):495-499
59. [59]
  59 Niu X, Gulati S, Edel J B, Demello A J. Lab Chip, 2008, 8(11):1837-1841
60. [60]
  60 Liu K, Ding H J, Chen Y, Zhao X Z. Microfluid. Nanofluid., 2007, 3(2):239-243
61. [61]
  61 Bremond N, Thiam A R, Bibette J. Phys. Rev. Lett., 2008, 100(2):024501
62. [62]
  62 Lai A, Bremond N, Stone H A. J. Fluid Mech., 2009, 632(10):97-107
63. [63]
  63 Yang L, Wang K, Tan J, Lu Y C, Luo G S. Microfluid. Nanofluid., 2012, 12(5):715-722
64. [64]
  64 Liu Z M, Cao R T, Pang Y, Shen F. Exp. Fluids, 2015, 56(2):1-4
65. [65]
  65 Wang K, Lu Y, Yang L, Luo G S. AICHE Journal, 2013, 59(2):643-649
66. [66]
  66 Wang K, Lu Y, Tostado C P, Yang L, Luo G S. Chem. Eng. J., 2013, 227(7):90-96
67. [67]
  67 Mazutis L, Griffiths A D. Lab Chip, 2012, 12(10):1800-1806
68. [68]
  68 Deng N N, Sun S X, Wang W, Ju X J, Xie R, Chu L. Lab Chip, 2013, 13(18):3653-3657
69. [69]
  69 Mazutis L, Baret J C, Griffiths A D. Lab Chip, 2009, 9(18):2665-2672
70. [70]
  70 Fryd M M, Mason T G. Soft Matter, 2014, 10(26):4662-4673
71. [71]
  71 Liu K, Qin J. Nanotechnology, 2013, 24(12):1079-1094
72. [72]
  72 Tullis J, Park C L, Abbyad P. Lab Chip, 2014, 14(17):3285-3289
73. [73]
  73 Sarrazin F, Prat L, Miceli N D, Cristobal G, Link D R, Weitz D A. Chem. Eng. Sci., 2007, 62(4):1042-1048
74. [74]
  74 Wang W. Lab Chip, 2009, 9(11):1504-1506
75. [75]
  75 Hao G, Duits M H G, Mugele F. Int. J. Mol. Sci., 2011, 12(4):2572-2597
76. [76]
  76 Schoeman R M, Kemna E W M, Wolbers F, Albert V D B. Electrophoresis, 2014, 35(2-3):385-392
77. [77]
  77 ZHANG An-Liang, XIA Xing-Hua. Chinese J. Anal. Chem., 2011, 39(5):765-769 章安良, 夏兴华. 分析化学, 2011, 39(5):765-769
78. [78]
  78 Fu X T, Zha Y, Zhang A L. TELKOMNIKA, 2013,11(7):3767-3773
79. [79]
  79 Sesen M, Alan T, Neild A. Lab Chip, 2014, 14(17):3325-3333
80. [80]
  80 Luong T D, Nguyen N T, Sposito A. Appl. Phys. Lett., 2012, 100(25):254105
81. [81]
  81 Xu B, Nguyen N T, Wong T N. Biomicrofluidics, 2012, 6(1):263-268
82. [82]
  82 Peng C H, Nguyen N T. Phys. Fluids, 2013, 25(8):840-840
83. [83]
  83 Kotz K T, Gu Y, Gw. F. J. Am. Chem. Soc., 2005, 127(16):5736-5737
84. [84]
  84 Lorenz R M, Edgar J S, Jeffries G D M, Zhao Y, McGloin D, Chiu D T. Anal. Chem., 2007, 79(1):224-228
85. [85]
  85 Jin H J, Lee K H, Destgeer G, Kang S L, Cho H, Ha B H, Sung H J. Microfluid. Nanofluid., 2014, 18(11):1522-1529
86. [86]
  86 Jin B J, Yoo J Y. Exp. Fluids, 2012, 52(1):235-245
87. [87]
  87 Yan Y, Guo D, Luo J, Wen S. Biochip Journal, 2013, 7(4):325-334
1. [1]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
2. [2]
  Kejie Li , Dongmei Qi . Exploration and Practice of Traditional Chinese Medicine Chemistry Laboratory Management Based on the “Smart Laboratory”. University Chemistry, 2024, 39(10): 353-360. doi: 10.12461/PKU.DXHX202406080
3. [3]
  Xinyu Liu , Weiran Hu , Zhengkai Li , Wei Ji , Xiao Ni . Algin Lab: Surging Luminescent Sea. University Chemistry, 2024, 39(5): 396-404. doi: 10.3866/PKU.DXHX202312021
4. [4]
  Limin Zhou , Yan Zhang , Yan Chen . Analysis on Fine Management of Chemical Laboratories in Universities. University Chemistry, 2024, 39(10): 143-148. doi: 10.3866/PKU.DXHX202401038
5. [5]
  Gaofeng Zeng , Shuyu Liu , Manle Jiang , Yu Wang , Ping Xu , Lei Wang . Micro/Nanorobots for Pollution Detection and Toxic Removal. University Chemistry, 2024, 39(9): 229-234. doi: 10.12461/PKU.DXHX202311055
6. [6]
  Yu Wang , Shoulei Zhang , Tianming Lv , Yan Su , Xianyu Liu , Fuping Tian , Changgong Meng . Introduce a Comprehensive Inorganic Synthesis Experiment: Synthesis of Nano Zinc Oxide via Microemulsion Using Waste Soybean Oil. University Chemistry, 2024, 39(7): 316-321. doi: 10.3866/PKU.DXHX202311035
7. [7]
  Jiaqi Chen , Shuwei Chen , Suocai Ren , Yue Sun , Chunhui Luan , Xu Wu . Exploring the People-Centered Safety Construction Model in Basic Chemistry Laboratories: A Case Study in Analytical Chemistry Laboratories. University Chemistry, 2024, 39(7): 264-271. doi: 10.3866/PKU.DXHX202311009
8. [8]
  Wei Yan , Cailing Wang , Li Wang , Yonghai Song . Promoting the Reform of Basic Chemistry Experimental Courses through Laboratory Skill Competition. University Chemistry, 2024, 39(10): 189-194. doi: 10.3866/PKU.DXHX202403042
9. [9]
  Zhenyu Feng , Zhaozhen Cao , Jinhua Zhan . Exploration of Online Training System for Large-Scale Instrument in Open Laboratory of Universities. University Chemistry, 2024, 39(4): 1-6. doi: 10.3866/PKU.DXHX202311016
10. [10]
  Qian Shao , Jiajing Tan , Yongmei Chen , Jiyue Jing , Zhuo Wang . Exploration and Practice on the Management of Extracurricular Innovation Laboratories in Chemistry. University Chemistry, 2024, 39(4): 19-25. doi: 10.3866/PKU.DXHX202310119
11. [11]
  Zhihui Wen , Zhanheng Feng , Xue Qi , Xiaohang Qiu . Exploration and Practice in Inorganic Chemistry Laboratory Management under Broad-based Admission Programs. University Chemistry, 2024, 39(6): 181-188. doi: 10.3866/PKU.DXHX202310081
12. [12]
  Fangna Dai , Rongming Wang , Zhicheng Zhang . Reform and Practice of Case Teaching on “Laboratory Safety Management Standards and Training”. University Chemistry, 2024, 39(10): 121-127. doi: 10.12461/PKU.DXHX202403036
13. [13]
  Zhaohu Li , Weidong Wang , Yuhao Liu , Mingzhe Han , Lingling Wei , Huan Jiao . Research on the Safety Management and Disposal of Chemical Laboratory Waste. University Chemistry, 2024, 39(10): 128-136. doi: 10.3866/PKU.DXHX202312090
14. [14]
  Dongxia Zhang , Sijia Hao , Jiarui Wang , Jiwei Wang , Xiaogang Dong , Liang Jiao . Construction and Reflection on the Safety Management of Hazardous Chemicals in University Laboratories. University Chemistry, 2024, 39(10): 229-235. doi: 10.12461/PKU.DXHX202403078
15. [15]
  Wenyi Liang , Chi Zhang , Yuxin Fang , Meiyu Lin , Yaqian Duan , Songzhang Shen , Juan Su . Construction and Practice of a Safety Education System on “Teaching-Examination Linkage” in Chemical Laboratories. University Chemistry, 2024, 39(10): 330-336. doi: 10.12461/PKU.DXHX202404127
16. [16]
  Zijian Jiang , Yuang Liu , Yijian Zong , Yong Fan , Wanchun Zhu , Yupeng Guo . Preparation of Nano Zinc Oxide by Microemulsion Method and Study on Its Photocatalytic Activity. University Chemistry, 2024, 39(5): 266-273. doi: 10.3866/PKU.DXHX202311101
17. [17]
  Jingfeng Lan , Li Wu , Guangnong Lu , Liu Yang , Xiaolong Li , Xiangyang Xu , Yongwen Shen , E Yu . Application of 3E Method in the Negative List Management System in Teaching Laboratory. University Chemistry, 2024, 39(4): 54-61. doi: 10.3866/PKU.DXHX202310130
18. [18]
  Mengchen Liao , Hua Yang , Younian Liu , Zhen He , Maolin Zhang , Qing Liu , Jiwen Ding . Exploration and Implementation of Refined Management Practices in Basic Organic Chemistry Laboratories. University Chemistry, 2024, 39(10): 164-173. doi: 10.3866/PKU.DXHX202403041
19. [19]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-. doi: 10.3866/PKU.WHXB202311030
20. [20]
  Xuanzhu Huo , Yixi Liu , Qiyu Wu , Zhiqiang Dong , Chanzi Ruan , Yanping Ren . Integrated Experiment of “Electrolytic Preparation of Cu₂O and Gasometric Determination of Avogadro’s Constant: Implementation, Results, and Discussion: A Micro-Experiment Recommended for Freshmen in Higher Education at Various Levels Across the Nation. University Chemistry, 2024, 39(3): 302-307. doi: 10.3866/PKU.DXHX202308095

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(794)
HTML views(241)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142