Citation: Lei ZHANG, Cheng HE, Yang JIAO. An azo-based fluorescent probe for the detection of hypoxic tumor cells[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(6): 1162-1172. doi: 10.11862/CJIC.20250081 shu

An azo-based fluorescent probe for the detection of hypoxic tumor cells

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116024, China

Corresponding author: Yang JIAO, jiaoyang@dlut.edu.cn
Received Date: 12 March 2025
Revised Date: 3 April 2025

Figures(8)

The abnormal metabolic activity of the tumor can increase the oxygen consumption in tumor cells, and the poor blood perfusion often happens in tumor regions as well, which are the main reasons that result in a hypoxic situation in the tumor. A fluorescence probe, AQD, with selective response toward hypoxia was designed for the detection of hypoxic tumor cells, which was obtained by the covalent connection of a large planar conjugated fluorophore with good fluorescence stability and a N, N-dimethylaniline moiety via the azo bond. The introduction of the azo bond in AQD caused significant fluorescence emission quenching, and the probe was reduced under hypoxic conditions to release the fluorophore via breaking the azo bond, resulting in the gradual recovery of fluorescence emission. Probe AQD exhibited a remarkable fluorescence response in hypoxic conditions, high selectivity, and good biocompatibility, which was successfully used for the imaging of hypoxic tumor cells and realized the detection of hypoxic A549 cells.
- hypoxia response,
- azo compound,
- fluorescent probe,
- fluorescence detection,
- cell imaging
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