Citation: Xiaotong LU, Pan ZHANG, Zijie ZHAO, Lei HUANG, Hongwei ZUO, Lili LIANG. Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(8): 1523-1532. doi: 10.11862/CJIC.20250073 shu

Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes

Department of Pharmaceutical Engineering, Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui 233030, China

Corresponding author: Lili LIANG, liangjyt@163.com
Received Date: 7 March 2025
Revised Date: 27 May 2025

Figures(9)

Two metal complexes [In(HL)(NO₃)₃] (1) and [Dy(L)(CH₃OH)_0.89(H₂O)_1.11(NO₃)₂]·0.11H₂O (2) were synthesized with N′-[(1E)-pyridine-2-methylene]pyridine-4-carbon hydrazide (HL) ligand and indium /dysprosium ions. The single-crystal X-ray diffraction results show that complexes 1 and 2 have a zero-dimensional mononuclear structure formed by one ligand connecting one metal ion. Powder X-ray diffraction shows that the sample purity ofcomplexes 1 and 2 is high, and thermogravimetric analysis shows that both complexes have good thermal stability. The in vitro antiproliferative activity study shows that complex 1 has better antitumor activity than cisplatin against human hepatocellular carcinoma cell line SMMC-7721, human breast cancer cell line MDA-MB-231, and human non-small cell lung cancer cell line A549; complex 2 has better anti-tumor activity than cisplatin against SMMC-7721 and A549 cells. In comparison, the toxicity of complexes 1 and 2 to normal cells (HK-2) is lower than that of cisplatin. The wound healing experiment shows that complexes 1 and 2 can inhibit the migration ability of A549 cells in a concentration-dependent manner. In addition, complex 2 has a significant antibacterial effect on Escherichia coli, with an inhibition zone diameter of 22 mm.
- crystal structure,
- complex,
- Schiff base,
- anti-tumor,
- antibacterial
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