Citation: Di WU, Ruimeng SHI, Zhaoyang WANG, Yuehua SHI, Fan YANG, Leyong ZENG. Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135 shu

Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell

Di WU ¹ ,
Ruimeng SHI ² ,
Zhaoyang WANG ¹ ,
Yuehua SHI ¹ ,
Fan YANG ^3,, ,
Leyong ZENG ^1,,

1.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Materials Science, Hebei University, Baoding, Hebei 071000, China
2.
College of Basic Medical Sciences, Hebei University, Baoding, Hebei 071000, China
3.
Department of Urology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China

Corresponding author: Fan YANG, yangfan19862014@163.com Leyong ZENG, zengly@hbu.cn
Received Date: 18 April 2024
Revised Date: 25 June 2024

Figures(7)

Mesoporous nanomaterials showed potential application in drug delivery, but non-specific leakage and multi-drug resistance seriously restricted the efficacy of chemotherapy. Based on the synthesis of mesoporous poly-dopamine (MPDA), pH/photothermal dual-responsive MPDA-DOX@PCM delivery nanosystem was constructed by loading chemotherapy drug doxorubicin (DOX) and coating phase-change material (PCM) 1-tetradecanol, by which the photothermal therapy (PTT) and chemotherapy were achieved towards drug-resistant bladder cancer cell (BIU-87/ADR). The results indicated that the size of MPDA-DOX@PCM was about 179 nm, the max loading rate of DOX was 22%, and the photothermal conversion efficiency was up to 49.1%. Under the conditions of pH=7.4 and 25 ℃, the accumulative release rate of DOX was 4.57%, but can increase to 60.13% with the conditions of pH=5.5 and 45 ℃. Under the irradiation of 808 nm laser, the viability of BIU-87/ADR cells incubated with MPDA-DOX@PCM decreased to 9.5%, demonstrating the excellent combination performance of PTT/chemotherapy.
- mesoporous polydopamine,
- drug delivery,
- dual-response,
- combination therapy,
- bladder cancer cell
1. [1]
  Bray F, Laversanne M, Sung H Y A, Ferlay J, Siegel R L, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA-Cancer J. Clin., 2024,74(3):229-263.
2. [2]
  Wei G Q, Wang Y, Yang G, Wang Y, Ju R. Recent progress in nanomedicine for enhanced cancer chemotherapy[J]. Theranostics, 2021,11(13):6370-6392. doi: 10.7150/thno.57828
3. [3]
  Liu H, Jiang H, Liu X H, Wang X M. Tunable nanomaterials of intracellular crystallization for in situ biolabeling and biomedical imaging[J]. Chem. Biomed. Imaging, 2023,1(9):767-784. doi: 10.1021/cbmi.3c00021
4. [4]
  Pei Z F, Lei H L, Cheng L. Bioactive inorganic nanomaterials for cancer theranostics[J]. Chem. Soc. Rev., 2023,52(6):2031-2081. doi: 10.1039/D2CS00352J
5. [5]
  Patra J K, Das G, Fraceto L F, Campos E V R, Rodriguez-Torres M D P, Acosta-Torres L S, Diaz-Torres L A, Grillo R, Swamy M K, Sharma S, Habtemariam S, Shin H S. Nano based drug delivery systems: Recent developments and future prospects[J]. J. Nanobiotechnol., 2018,1671.
6. [6]
  Manzano M, Vallet-Regí M. Mesoporous silica nanoparticles for drug delivery[J]. Adv. Funct. Mater., 2020,30(2)1902634. doi: 10.1002/adfm.201902634
7. [7]
  He S N, Pan H F, Zhang J Y. Advances of typical mesoporous materials and the application in drug delivery[J]. Mater. Res. Express, 2023,10(4)042001.
8. [8]
  Wu H, Wang M D, Zhu J D, Li Z L, Wang W Y, Gu L H, Shen F, Tang T. Mesoporous nanoparticles for diagnosis and treatment of liver cancer in the era of precise medicine[J]. Pharmaceutics, 2022,14(9)1760.
9. [9]
  Vallet-Regí M, Schüth F, Lozano D, Colilla M, Manzano M. Engineering mesoporous silica nanoparticles for drug delivery: Where are we after two decades?[J]. Chem. Soc. Rev., 2022,51(13):5365-5451.
10. [10]
  Zhou L B, Jing Y, Liu Y B, Liu Z H, Gao D Y, Chen H B, Song W Y, Wang T, Fang X F, Qin W P, Yuan Z, Dai S, Qiao Z A, Wu C. Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics[J]. Theranostics, 2018,8(3):663-675.
11. [11]
  Shi Y, Chang L N, Pan C S, Zhang H, Yang Y Q, Wu A G, Zeng L Y. Biodegradable hollow mesoporous bimetallic nanoreactors to boost chemodynamic therapy[J]. J. Colloid Interf. Sci., 2024,656:93-103.
12. [12]
  Hou, Gong, Yang, Zhang, Yang, Chen, Y. Hybrid-membrane-decorated Prussian blue for effective cancer immunotherapy via tumor-associated macrophages polarization and hypoxia relief[J]. Adv. Mater., 2022,34(14)2200389.
13. [13]
  Wang Z Y, Li Z K, Shi Y H, Zeng L Y. Mesoporous polydopamine delivery system for intelligent drug release and photothermal‑ enhanced chemodynamic therapy using MnO₂ as gatekeeper[J]. Regen. Biomater., 2023,10rbad087.
14. [14]
  Sun Z Y, Li T Y, Mei T X, Liu Y, Wu K R, Le W J, Hu Y H. Nanoscale MOFs in nanomedicine applications: From drug delivery to therapeutic agents[J]. J. Mater. Chem. B, 2023,11(15):3273-3294.
15. [15]
  Wang Y N, Cheng W Y, Zhu J J, He L, Ren W Y, Bao D D, Piao J G. Programmed co-delivery of tamoxifen and docetaxel using lipid-coated mesoporous silica nanoparticles for overcoming CYP3A4-mediated resistance in triple-negative breast cancer treatment[J]. Biomed. Pharmacother., 2024,170116084.
16. [16]
  Tang X P, Hou Y, Zhang G L, Liu X. Thermo/pH dually responsive drug delivery systems based on mesoporous silica nanoparticles[J]. J. Control. Release, 2017,259:E158-E158.
17. [17]
  Thirupathi K, Santhamoorthy M, Radhakrishnan S, Ulagesan S, Nam T J, Phan T T V, Kim S C. Thermosensitive polymer-modified mesoporous silica for pH and temperature-responsive drug delivery[J]. Pharmaceutics, 2023,15(3)795.
18. [18]
  Chen Z J, Yang S C, Liu X L, Gao Y H, Dong X, Lai X, Zhu M H, Feng H Y, Zhu X D, Lu Q, Zhao M, Chen H Z, Lovell J F, Fang C. Nanobowl-supported liposomes improve drug loading and delivery[J]. Nano Lett., 2020,20(6):4177-4187.
19. [19]
  Zhang X, Wang S, Cheng G H, Yu P, Chang J, Chen X Y. Cascade drug-release strategy for enhanced anticancer therapy[J]. Matter, 2021,4(1):26-53.
20. [20]
  Yang Z B, Chen H R. The recent progress of inorganic-based intelligent responsive nanoplatform for tumor theranostics[J]. VIEW, 2022,3(6)20220009.
21. [21]
  Hu Y L, Li S K, Dong H, Weng L X, Yuwen L H, Xie Y N, Yang J, Shao J J, Song X J, Yang D L, Wang L H. Environment-responsive therapeutic platforms for the treatment of implant infection[J]. Adv. Healthcare Mater., 2023,12(26)2300985.
22. [22]
  Kaushik N, Borkar S B, Nandanwar S K, Panda P K, Ha Choi E, Kaushik N K. Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms[J]. J. Nanobiotechnol., 2022,20(1)152.
23. [23]
  Hyun D C, Lu P, Choi S I, Jeong U, Xia Y N. Microscale polymer bottles corked with a phase-change material for temperature-controlled release[J]. Angew. Chem. Int. Ed., 2013,52(40):10468-10471.
24. [24]
  Zhang S C, Li Q Z, Yang N, Shi Y H, Ge W, Wang W J, Huang W, Song X J, Dong X C. Phase-change materials based nanoparticles for controlled hypoxia modulation and enhanced phototherapy[J]. Adv. Funct. Mater., 2019,29(49)1906805.
25. [25]
  Regenold M, Kaneko K, Wang X, H , Peng H B, Evans J C, Bannigan P, Allen C. Triggered release from thermosensitive liposomes improves tumor targeting of vinorelbine[J]. J. Control. Release, 2023,354:19-33.
26. [26]
  Lei B, Sun M J, Chen M X, Xu S H, Liu H L. pH and temperature double‑switch hybrid micelles for controllable drug release[J]. Langmuir, 2021,37(50):14628-14637.
27. [27]
  Cheng H, He Y, Lu J Y, Yan Z W, Song L M, Mao Y L, Di D H, Gao Y K, Zhao Q F, Wang S L. Degradable iron-rich mesoporous dopamine as a dual-glutathione depletion nanoplatform for photothermal-enhanced ferroptosis and chemodynamic therapy[J]. J. Colloid Interf. Sci., 2023,639:249-262.
28. [28]
  Wang Z Y, Shi Y H, Shi Y, Zhang J H, Hao R, Zhang G W, Zeng L. Ultrasmall gold coated mesoporous polydopamine nanoprobe to enhance chemodynamic therapy by self-supplying H₂O₂ and photothermal stimulation[J]. ACS Appl. Mater. Interfaces, 2022,14(49):54478-54487.
29. [29]
  Yao S K, Chen Y C, Ding W Z, Xu F W, Liu Z P, Li Y H, Wu Y P, Li S M, He W J, Guo Z J. Single-atom engineering of hemicyanine and its amphiphilic derivative for optimized near infrared phototheranostics[J]. Chem. Sci., 2022,14(5):1234-1243.
30. [30]
  WU D, FAN M, ZHANG L Y, XING J J, LV S F, ZENG L Y. Controllable synthesis, photothermal conversion and in vitro photothermal therapy of gold nanostars/nanobipyramids[J]. Chin. J. Lumin., 2018,39(3):280-286.
1. [1]
  Aiai WANG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress of bimetallic organic framework in tumor diagnosis and treatment. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1825-1839. doi: 10.11862/CJIC.20240225
2. [2]
  Wenjun Yang , Qiaoling Tan , Wenjiao Xie , Xiaoyu Pan , Youyong Yuan . Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments. University Chemistry, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150
3. [3]
  Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
4. [4]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
5. [5]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
6. [6]
  Bing LIU , Huang ZHANG , Hongliang HAN , Changwen HU , Yinglei ZHANG . Visible light degradation of methylene blue from water by triangle Au@TiO₂ mesoporous catalyst. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 941-952. doi: 10.11862/CJIC.20230398
7. [7]
  Jing SU , Bingrong LI , Yiyan BAI , Wenjuan JI , Haiying YANG , Zhefeng Fan . Highly sensitive electrochemical dopamine sensor based on a highly stable In-based metal-organic framework with amino-enriched pores. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1337-1346. doi: 10.11862/CJIC.20230414
8. [8]
  Yuanpei ZHANG , Jiahong WANG , Jinming HUANG , Zhi HU . Preparation of magnetic mesoporous carbon loaded nano zero-valent iron for removal of Cr(Ⅲ) organic complexes from high-salt wastewater. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1731-1742. doi: 10.11862/CJIC.20240077
9. [9]
  Ziheng Zhuang , Xiao Xu , Kin Shing Chan . Superdrugs for Superbugs. University Chemistry, 2024, 39(9): 128-133. doi: 10.3866/PKU.DXHX202309040
10. [10]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
11. [11]
  Zeyu XU , Anlei DANG , Bihua DENG , Xiaoxin ZUO , Yu LU , Ping YANG , Wenzhu YIN . Evaluation of the efficacy of graphene oxide quantum dots as an ovalbumin delivery platform and adjuvant for immune enhancement. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1065-1078. doi: 10.11862/CJIC.20240099
12. [12]
  Xiyuan Su , Zhenlin Hu , Ye Fan , Xianyuan Liu , Xianyong Lu . Change as You Want: Multi-Responsive Superhydrophobic Intelligent Actuation Material. University Chemistry, 2024, 39(5): 228-237. doi: 10.3866/PKU.DXHX202311059
13. [13]
  Peng Zhan . Practice and Reflection in Training Medicinal Chemistry Graduate Students. University Chemistry, 2024, 39(6): 112-121. doi: 10.3866/PKU.DXHX202402022
14. [14]
  Zhibei Qu , Changxin Wang , Lei Li , Jiaze Li , Jun Zhang . Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles. University Chemistry, 2024, 39(7): 278-286. doi: 10.3866/PKU.DXHX202311039
15. [15]
  Meng Lin , Heng Zhang , Shiling Yuan . Exploring a Combined Theory-Practice-Simulation Teaching Model in Physical Chemistry: A Case Study of Surface Tension. University Chemistry, 2025, 40(4): 189-194. doi: 10.12461/PKU.DXHX202407053
16. [16]
  Baohua LÜ , Yuzhen LI . Anisotropic photoresponse of two-dimensional layered α-In₂Se₃(2H) ferroelectric materials. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1911-1918. doi: 10.11862/CJIC.20240105
17. [17]
  Xinzhe HUANG , Lihui XU , Yue YANG , Liming WANG , Zhangyong LIU , Zhongjian WANG . Preparation and visible light responsive photocatalytic properties of BiSbO₄/BiOBr. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 284-292. doi: 10.11862/CJIC.20240212
18. [18]
  Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
19. [19]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
20. [20]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(807)
HTML views(182)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142