Citation: Siyi ZHONG, Xiaowen LIN, Jiaxin LIU, Ruyi WANG, Tao LIANG, Zhengfeng DENG, Ao ZHONG, Cuiping HAN. Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093 shu

Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots

Siyi ZHONG ^{1, 2} ,
Xiaowen LIN ¹ ,
Jiaxin LIU ^{1, 2} ,
Ruyi WANG ^{1, 2} ,
Tao LIANG ^{1, 2} ,
Zhengfeng DENG ^{1, 2} ,
Ao ZHONG ^{1, 2} ,
Cuiping HAN ^{1, 3,,}

1.
School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China
2.
National Demonstration Center for Experimental Teaching Basic Medicine Science Education, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China
3.
Department of Radiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

Corresponding author: Cuiping HAN, hancp@xzhmu.edu.cn
Received Date: 25 March 2024
Revised Date: 24 June 2024

Figures(6)

Fluorescent magnetic gadolinium-doped carbon dots (Gd-CDs) were prepared using a high-temperature carbonization method. The prepared Gd-CDs emitted bright green fluorescence with a fluorescence quantum yield of 32.6% and a T1 relaxation efficiency of up to 9.02 L·mmol^-1·s^-1. By conjugating with the ovarian cancer-specific antibody Anti-HE4, the resulting Anti-HE4/Gd-CDs nanoprobes could perform specific fluorescent imaging and T1-weighted imaging of SKOV-3 ovarian cancer cells. The fluorescence intensity was proportional to the concentration of SKOV-3 cells, with a detection limit of 658 cell·mL^-1. This method was applied to the detection of SKOV-3 cells in blood samples.
- gadolinium-doped carbon dots,
- targeting probe,
- fluorescence imaging,
- magnetic resonance imaging,
- ovarian cancer cell
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