Citation: Donghui PAN, Yuping XU, Xinyu WANG, Lizhen WANG, Junjie YAN, Dongjian SHI, Min YANG, Mingqing CHEN. Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(4): 669-676. doi: 10.11862/CJIC.20230468 shu

Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging

Donghui PAN ^{1, 2} ,
Yuping XU ² ,
Xinyu WANG ² ,
Lizhen WANG ² ,
Junjie YAN ² ,
Dongjian SHI ¹ ,
Min YANG ^2,, ,
Mingqing CHEN ^1,,

1.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, School of Chemical and Material Engineering, Wuxi, Jiangsu 214122, China
2.
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China

Corresponding author: Min YANG, yangmin@jsinm.org Mingqing CHEN, mqchen@jiangnan.edu.cn
Received Date: 13 December 2023
Revised Date: 11 March 2024

Figures(9)

Melanin nanoparticle (MNP) was modified by polyethylene glycols (PEG), and the resulting compound (PEG-MNP) was obtained. The ⁶⁸Ga labeled PEG-MNP was prepared by chelating radioactive ⁶⁸Ga³⁺ ions with high labeling yield (95.6%±1.9%) and radiochemical purity (>95%). The stability of the labeling compound as well. Then ⁶⁸Ga-PEG-MNP for simulating PM_2.5 particles (particulate matter 2.5, size < 2.5 μm) was obtained through nebulization. After inhaling the nebulized particles, whole-body positron emission tomography (PET) in mice was performed. It revealed that nebulized ⁶⁸Ga - PEG - MNP diffused from the trachea to the bilateral lobe area of the lungs and retained in the lungs. Quantification of PET images showed that the uptakes of the trachea and lung were (7.20±2.44)%·g^-1, (4.46±1.04)%·g^-1, (4.91±2.48)%·g^-1, (4.71±2.39)%·g^-1, (3.34±1.14)%·g^-1, and (17.90±3.75)%·g^-1, (18.10±4.52)%·g^-1, (19.49±6.11)%·g^-1, (19.19±2.83)%·g^-1, (20.87±2.40)%·g^-1 at 0 min, 30 min, 1 h, 2 h, 4 h after administration of the nebulized ⁶⁸Ga-PEG-MNP, respectively. The results were highly consistent with the findings of ex-vivo radiographic autoradiography.
- positron emission tomography,
- ⁶⁸Ga,
- melanin nanoparticle,
- PM_2.5
1. [1]
  Louis S, Carlson A K, Suresh A, Rim J, Mays M, Ontaneda D, Dhawan A. Impacts of climate change and air pollution on neurologic health, disease, and practice: A scoping review[J]. Neurology, 2023,100(10):474-483. doi: 10.1212/WNL.0000000000201630
2. [2]
  Thiankhaw K, Chattipakorn N, Chattipakorn S C. PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes[J]. Environ. Pollut., 2022,292118320. doi: 10.1016/j.envpol.2021.118320
3. [3]
  Chen C, Chen H, van Donkelaar A, Burnett R T, Martin R V, Chen L, Tjepkema M, Kirby-McGregor M, Kaufman J. Using parametric g-computation to estimate the effect of long-term exposure to air pollution on mortality risk and simulate the benefits of hypothetical policies: The Canadian community health survey cohort (2005 to 2015)[J]. Environ. Health Perspect., 2023,131(3)037010. doi: 10.1289/EHP11095
4. [4]
  Liu Z T, Fang C L, Sun B, Liao X. Governance matters: Urban expansion, environmental regulation, and PM2.5 pollution[J]. Sci. Total Environ., 2023,876162788. doi: 10.1016/j.scitotenv.2023.162788
5. [5]
  Barzgar F, Sadeghi-Mohammadi S, Aftabi Y, Zarredar H, Shakerkhatibi M, Sarbakhsh P, Gholampour A. Oxidative stress indices induced by industrial and urban PM_2.5-bound metals in A549 cells[J]. Sci. Total Environ., 2023,877162726. doi: 10.1016/j.scitotenv.2023.162726
6. [6]
  Guo C C, Lyu Y, Xia S S, Ren X K, Li Z F, Tian F J, Zheng J P. Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells[J]. Ecotoxicol. Environ. Saf., 2023,249114350. doi: 10.1016/j.ecoenv.2022.114350
7. [7]
  Song J, Han K Y, Wang Y, Qu R R, Liu Y, Wang S L, Wang L B, An Z, Li J, Wu H, Wu W D. Microglial activation and oxidative stress in PM_2.5-induced neurodegenerative disorders[J]. Antioxidants, 2022,11(8)1482. doi: 10.3390/antiox11081482
8. [8]
  Wang Y X, Zhong Y J, Hou T F, Liao J P, Zhang C, Sun C, Wang G F. PM2.5 induces EMT and promotes CSC properties by activating Notch pathway in vivo and vitro[J]. Ecotoxicol. Environ. Saf., 2019,178:159-167. doi: 10.1016/j.ecoenv.2019.03.086
9. [9]
  Zhang Y T, Zhang L K, Chen W W, Zhang Y Y, Wang X M, Dong Y Y, Zhang W X, Lin X X. Shp2 regulates PM2.5-induced airway epithelial barrier dysfunction by modulating ERK1/2 signaling pathway[J]. Toxicol. Lett., 2021,350:62-70. doi: 10.1016/j.toxlet.2021.07.002
10. [10]
  Zhao C, Pu W, Niu M Y, Wazir J, Song S Y, Wei L L, Li L, Su Z L, Wang H W. Respiratory exposure to PM2.5 soluble extract induced chronic lung injury by disturbing the phagocytosis function of macrophage[J]. Environ. Sci. Pollut. Res., 2022,29(10):13983-13997. doi: 10.1007/s11356-021-16797-9
11. [11]
  Seifert R, Emmett L, Rowe S P, Herrmann K, Hadaschik B, Calais J, Giesel F L, Reiter R. Maurer T, Heck M, Gafita A, Morris M J, Fanti S, Weber W A, Hope T A, Hofman M S, Fendler W P, Eiber M. Second version of the prostate cancer molecular imaging standardized evaluation framework including response evaluation for clinical trials (PROMISE V2)[J]. Eur. Urol., 2023,83(5):405-412. doi: 10.1016/j.eururo.2023.02.002
12. [12]
  Jain P, Chaney A M, Carlson M L, Jackson I M, Rao A, James M L. Neuroinflammation PET imaging: Current opinion and future directions[J]. J. Nucl. Med., 2020,61(8):1107-1112. doi: 10.2967/jnumed.119.229443
13. [13]
  Taralli S, Lorusso M, Perrone E, Perotti G, Zagaria L, Calcagni M L. PET/CT with fibroblast activation protein inhibitors in breast cancer: Diagnostic and theranostic application-A literature review[J]. Cancers, 2023,15(3)908. doi: 10.3390/cancers15030908
14. [14]
  Pan D H, Sheng J, Wang X Y, Huang Q H, Yan J J, Wang L Z, Yang R L, Shi D J, Xu Y P, Chen M Q. In vivo SPECT imaging of an ¹³¹I labeled PM 2.5 mimic substitute[J]. Nucl. Sci. Technol., 2020,31:1-8. doi: 10.1007/s41365-019-0712-1
15. [15]
  Yang M, Fan Q L, Zhang R P, Cheng K, Yan J J, Pan D H, Ma X W, Lu A, Cheng Z. Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging[J]. Biomaterials, 2015,69:30-37. doi: 10.1016/j.biomaterials.2015.08.001
16. [16]
  Tian L Y, Li X, Ji H X, Yu Q, Yang M J, Guo L P, Huang L P, Gao W Y. Melanin-like nanoparticles: Advances in surface modification and tumour photothermal therapy[J]. J. Nanobiotechnology, 2022,20(1)485. doi: 10.1186/s12951-022-01698-x
17. [17]
  Jung W S, Lee D Y, Moon E, Jon S. Nanoparticles derived from naturally occurring metal chelators for theranostic applications[J]. Adv. Drug Deliv. Rev., 2022,191114620. doi: 10.1016/j.addr.2022.114620
18. [18]
  Marcovici I, Coricovac D, Pinzaru I, Macasoi I G, Popescu R, Chioibas R, Zupko I, Dehelean C A. Melanin and melanin-functionalized nanoparticles as promising tools in cancer research-A review[J]. Cancers, 2022,14(7)1838. doi: 10.3390/cancers14071838
19. [19]
  Fan Q L, Cheng K, Hu X, Ma X W, Zhang R P, Yang M, Lu X M, Xing L, Huang W, Gambhir S S, Cheng Z. Transferring biomarker into molecular probe: Melanin nanoparticle as a naturally active platform for multimodality imaging[J]. J. Am. Chem. Soc., 2014,136:15185-15194. doi: 10.1021/ja505412p
20. [20]
  Zhou N N, Liu C, Guo X Y, Xu Y P, Gong J F, Qi C S, Zhang X T, Yang M, Zhu H, Shen L, Yang Z. Impact of ⁶⁸Ga-NOTA-MAL-MZHER2 PET imaging in advanced gastric cancer patients and therapeutic response monitoring[J]. Eur. J. Nucl. Med. Mol. Imaging, 2021,48(1):161-175. doi: 10.1007/s00259-020-04898-5
21. [21]
  Kendrick J, Francis R J, Hassan G M, Rowshanfarzad P, Ong J S L, Ebert M A. Fully automatic prognostic biomarker extraction from metastatic prostate lesion segmentations in whole-body[⁶⁸Ga]Ga-PSMA-11 PET/CT images[J]. Eur. J. Nucl. Med. Mol. Imaging, 2022,50(1):67-79. doi: 10.1007/s00259-022-05927-1
22. [22]
  Fortunati E, Argalia G, Zanoni L, Fanti S, Ambrosini V. New PET radiotracers for the imaging of neuroendocrine neoplasms[J]. Curr. Treat. Options Oncol., 2022,23(5):703-720. doi: 10.1007/s11864-022-00967-z
23. [23]
  Yan Q S, Zhong J W, Liu Y, Peng S M, Feng P J, Zhong Y H, Hu H Z. Synthesis and preclinical evaluation of a heterodimeric radioligand targeting fibroblast activation protein and integrin-α_vβ₃[J]. Eur. J. Med. Chem., 2023,251115279. doi: 10.1016/j.ejmech.2023.115279
1. [1]
  Yongjie ZHANG , Bintong HUANG , Yueming ZHAI . Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2318-2334. doi: 10.11862/CJIC.20240247
2. [2]
  Zhuo WANG , Xiaotong LI , Zhipeng HU , Junqiao PAN . Three-dimensional porous carbon decorated with nano bismuth particles: Preparation and sodium storage properties. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 267-274. doi: 10.11862/CJIC.20240223
3. [3]
  Chenye An , Abiduweili Sikandaier , Xue Guo , Yukun Zhu , Hua Tang , Dongjiang Yang . 红磷纳米颗粒嵌入花状CeO₂分级S型异质结高效光催化产氢. Acta Physico-Chimica Sinica, 2024, 40(11): 2405019-. doi: 10.3866/PKU.WHXB202405019
4. [4]
  Ziliang KANG , Jiamin ZHANG , Hong AN , Xiaohua LIU , Yang CHEN , Jinping LI , Libo LI . Preparation and water adsorption properties of CaCl₂@MOF-808 in-situ composite moulded particles. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2133-2140. doi: 10.11862/CJIC.20240282
5. [5]
  Qin ZHU , Jiao MA , Zhihui QIAN , Yuxu LUO , Yujiao GUO , Mingwu XIANG , Xiaofang LIU , Ping NING , Junming GUO . Morphological evolution and electrochemical properties of cathode material LiAl_0.08Mn_1.92O₄ single crystal particles. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1549-1562. doi: 10.11862/CJIC.20240022
6. [6]
  Zelong LIANG , Shijia QIN , Pengfei GUO , Hang XU , Bin ZHAO . Synthesis and electrocatalytic CO₂ reduction performance of metal-organic framework catalysts loaded with silver particles. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 165-173. doi: 10.11862/CJIC.20240409
7. [7]
  Wenjun Yang , Qiaoling Tan , Wenjiao Xie , Xiaoyu Pan , Youyong Yuan . Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments. University Chemistry, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150
8. [8]
  Liang TANG , Jingfei NI , Kang XIAO , Xiangmei LIU . Synthesis and X-ray imaging application of lanthanide-organic complex-based scintillators. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1892-1902. doi: 10.11862/CJIC.20240139
9. [9]
  Chunyang Zheng , Shiyu Liu , Nuo Yi , Hong Shang . The Adventures in the Kingdom of Plant Pigments. University Chemistry, 2024, 39(9): 170-176. doi: 10.3866/PKU.DXHX202308085
10. [10]
  Shaoming Dong , Yiming Niu , Yinghui Pu , Yongzhao Wang , Bingsen Zhang . Subsurface carbon modification of Ni-Ga for improved selectivity in acetylene hydrogenation reaction. Chinese Chemical Letters, 2024, 35(12): 109525-. doi: 10.1016/j.cclet.2024.109525
11. [11]
  Honglin Gao , Chunlin Yuan , Hongyu Chen , Aiyi Dong , Pan Gao , Guangjin Hou . Surface gallium hydride on Ga2O3 polymorphs: A comparative solid-state NMR study. Chinese Journal of Structural Chemistry, 2025, 44(4): 100561-100561. doi: 10.1016/j.cjsc.2025.100561
12. [12]
  Ziyi Liu , Feifei Guo , Tingting Cao , Youxuan Sun , Xutang Tao , Zeliang Gao . High thermal conductivity in Ga2TeO6 crystals: Synergistic effects of rigid polyhedral frameworks and stereochemically inert cations. Chinese Journal of Structural Chemistry, 2025, 44(4): 100544-100544. doi: 10.1016/j.cjsc.2025.100544
13. [13]
  Shitao Fu , Jianming Zhang , Cancan Cao , Zhihui Wang , Chaoran Qin , Jian Zhang , Hui Xiong . Study on the Stability of Purple Cabbage Pigment. University Chemistry, 2024, 39(4): 367-372. doi: 10.3866/PKU.DXHX202401059
14. [14]
  Endong YANG , Haoze TIAN , Ke ZHANG , Yongbing LOU . Efficient oxygen evolution reaction of CuCo₂O₄/NiFe-layered bimetallic hydroxide core-shell nanoflower sphere arrays. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 930-940. doi: 10.11862/CJIC.20230369
15. [15]
  Qiangqiang SUN , Pengcheng ZHAO , Ruoyu WU , Baoyue CAO . Multistage microporous bifunctional catalyst constructed by P-doped nickel-based sulfide ultra-thin nanosheets for energy-efficient hydrogen production from water electrolysis. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1151-1161. doi: 10.11862/CJIC.20230454
16. [16]
  Yuanpei ZHANG , Jiahong WANG , Jinming HUANG , Zhi HU . Preparation of magnetic mesoporous carbon loaded nano zero-valent iron for removal of Cr(Ⅲ) organic complexes from high-salt wastewater. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1731-1742. doi: 10.11862/CJIC.20240077
17. [17]
  Xinpeng LIU , Liuyang ZHAO , Hongyi LI , Yatu CHEN , Aimin WU , Aikui LI , Hao HUANG . Ga₂O₃ coated modification and electrochemical performance of Li_1.2Mn_0.54Ni_0.13Co_0.13O₂ cathode material. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1105-1113. doi: 10.11862/CJIC.20230488
18. [18]
  Junli Liu . Practice and Exploration of Research-Oriented Classroom Teaching in the Integration of Science and Education: a Case Study on the Synthesis of Sub-Nanometer Metal Oxide Materials and Their Application in Battery Energy Storage. University Chemistry, 2024, 39(10): 249-254. doi: 10.12461/PKU.DXHX202404023
19. [19]
  Zhuomin Zhang , Hanbing Huang , Liangqiu Lin , Jingsong Liu , Gongke Li . Course Construction of Instrumental Analysis Experiment: Surface-Enhanced Raman Spectroscopy for Rapid Detection of Edible Pigments. University Chemistry, 2024, 39(2): 133-139. doi: 10.3866/PKU.DXHX202308034
20. [20]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(278)
HTML views(22)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Preparation and in vivo tracing of 68Ga-labeled PM2.5 mimetic particles for positron emission tomography imaging

Metrics

通讯作者: 陈斌, bchen63@163.com

Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging