Citation: Yuanyuan LI, Xiulian LU, Xinyu LIU, Lei ZHANG, Su JING. Red-emitting selenium-doped carbon dots for versatile applications in biosensing and antibacterial activities[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(1): 173-181. doi: 10.11862/CJIC.20230360 shu

Red-emitting selenium-doped carbon dots for versatile applications in biosensing and antibacterial activities

School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

Corresponding author: Lei ZHANG, ias_lzhang@njtech.edu.cn Su JING, sjing@njtech.edu.cn
Received Date: 2 October 2023
Revised Date: 17 December 2023

Figures(5)

In this study, we successfully designed and synthesized selenium-doped carbon dots (Se-CDs) using easily available precursors of benzeneseleninic acid (BA) and o-phenylenediamine (o-PDA) through a one-step hydrothermal method. These Se-CDs emitted red-wavelength fluorescence and were utilized to develop a sensitive fluorescence sensor for detecting microRNA-21 (miR-21). By incorporating deoxyribonuclease Ⅰ (DNase Ⅰ)-mediated signal amplification, the detection limit for miR -21 was improved from 78 to 6.8 nmol·L^-1. Furthermore, we observed desirable inhibitory activity of the Se-CDs against Gram-negative bacteria of Escherichia coli (E. coli).
- selenium-doped carbon dots,
- red fluorescence,
- biosensing,
- microRNA-21,
- antibacterial
1. [1]
  Wang B Y, Cai H J, Waterhouse G I N, Qu X L, Yang B, Lu S Y. Carbon dots in bioimaging, biosensing and therapeutics: A comprehensive review[J]. Small Sci., 2022,22200012. doi: 10.1002/smsc.202200012
2. [2]
  Li P F, Sun L, Xue S S, Qu D, An L, Wang X Y, Sun Z C. Recent advances of carbon dots as new antimicrobial agents[J]. SmartMat, 2022,3:226-248. doi: 10.1002/smm2.1131
3. [3]
  Biju V. Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy[J]. Chem. Soc. Rev., 2014,43:744-764. doi: 10.1039/C3CS60273G
4. [4]
  Sun X C, Lei Y. Fluorescent carbon dots and their sensing applications[J]. Trac-Trends Anal. Chem., 2017,89:163-180. doi: 10.1016/j.trac.2017.02.001
5. [5]
  Li F, Li T Y, Sun C X, Xia J H, Jiao Y, Xu H P. Selenium-doped carbon quantum dots for free-radical scavenging[J]. Angew. Chem. Int. Ed., 2017,56:9910-9914. doi: 10.1002/anie.201705989
6. [6]
  Rosenkrans Z T, Sun T W, Jiang D W, Chen W Y, Barnhart T E, Zhang Z Y, Ferreira C A, Wang X D, Engle J W, Huang P, Cai W B. Selenium-doped carbon quantum dots act as broad-spectrum antioxidants for acute kidney injury management[J]. Adv. Sci., 2020,7(12)2000420. doi: 10.1002/advs.202000420
7. [7]
  Back T G. Selenium: Organoselenium chemistry // Scott R A. Encyclopedia of Inorganic and Bioinorganic Chemistry. New Jersey: John Wiley & Sons, 2011: 276
8. [8]
  Su R N, Shi J, Pu Y, Wang J X, Wang D, Chen J F. Synthesis of ultrasmall and monodisperse selenium-doped carbon dots from amino acids for free radical scavenging[J]. Ind. Eng. Chem. Res., 2020,59:16876-16883. doi: 10.1021/acs.iecr.0c03402
9. [9]
  Peng H S, Chiu D T. Soft fluorescent nanomaterials for biological and biomedical imaging[J]. Chem. Soc. Rev., 2015,44:4699-4722. doi: 10.1039/C4CS00294F
10. [10]
  Perez-Garrido L, Ortega-Muñoz M, Hernandez-Mateo F, Lopez-Jaramillo F J, Santoyo-Gonzalez F. Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro- oxidant activity[J]. Nano Res., 2023,16:7784-7791. doi: 10.1007/s12274-023-5442-3
11. [11]
  Sands K N, Gelfand B S, Back T G. One-pot synthesis of aryl selenonic acids and some unexpected byproducts[J]. J. Org. Chem., 2021,86:9938-9944. doi: 10.1021/acs.joc.1c01369
12. [12]
  Naveau A, Monteil-Rivera F, Guillon E, Dumonceau J. Interactions of aqueous selenium (-Ⅱ) and (Ⅳ) with metallic sulfide surfaces[J]. Environ. Sci. Technol., 2007,41:5376-5382. doi: 10.1021/es0704481
13. [13]
  Yang S W, Sun J, He P, Deng X X, Wang Z Y, Hu C Y, Ding G Q, Xie X M. Selenium doped graphene quantum dots as an ultrasensitive redox fluorescent switch[J]. Chem. Mat., 2015,27:2004-2011. doi: 10.1021/acs.chemmater.5b00112
14. [14]
  Kalytchuk S, Poláková K, Wang Y, Froning J P, Cepe K, Rogach A L, Zbořil R. Carbon dot nanothermometry: Intracellular photoluminescence lifetime thermal sensing[J]. ACS Nano, 2017,11:1432-1442. doi: 10.1021/acsnano.6b06670
15. [15]
  Asangani I A, Rasheed S A K, Nikolova D A, Leupold J H, Colburn N H, Post S, Allgayer H. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer[J]. Oncogene, 2008,27:2128-2136. doi: 10.1038/sj.onc.1210856
16. [16]
  Wang F T, Xu J, Hou Y Y, Huang K J, Yu X M, Zhou X, Tan X C. Matching capacitors to self-powered biosensors for signal amplification: Toward ultrasensitive electrochemical detection for MicroRNA-21-triggered catalytic hairpin assembly[J]. ACS Sustain. Chem. Eng., 2022,10:2673-2680. doi: 10.1021/acssuschemeng.1c07082
17. [17]
  Teradal N L, Jelinek R. Carbon nanomaterials in biological studies and biomedicine[J]. Adv. Healthc. Mater., 2017,61700574. doi: 10.1002/adhm.201700574
18. [18]
  Pradhan N, Das Adhikari S, Nag A, Sarma D D. Luminescence, plasmonic, and magnetic properties of doped semiconductor nanocrystals[J]. Angew. Chem. Int. Ed., 2017,56:7038-7054. doi: 10.1002/anie.201611526
19. [19]
  Koohy H, Down T A, Hubbard T J. Chromatin accessibility data sets show bias due to sequence specificity of the DNase Ⅰ enzyme[J]. PLoS One, 2013,8e69853. doi: 10.1371/journal.pone.0069853
20. [20]
  Mateescu B, Kowal E J K, van Balkom B W M, Bartel S, Bhattacharyya S N, Buzás E I, Buck A H, de Candia P, Chow F W N, Das S, Driedonks T A P, Fernández-Messina L, Haderk F, Hill A F, Jones J C, Van Keuren-Jensen K R, Lai C P, Lässer C, di Liegro I, Lunavat T R, Lorenowicz M J, Maas S L. N, Mäger I, Mittelbrunn M, Momma S, Mukherjee K, Nawaz M, Pegtel D M, Pfaffl M W, Schiffelers R M, Tahara H, Théry C, Tosar J P, Wauben M H M, Witwer K W, Nolte-'t Hoen E N M. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - An ISEV position paper[J]. J. Extracell. Vesicles, 2017,61286095. doi: 10.1080/20013078.2017.1286095
21. [21]
  Brigelius-Flohé R, Flohé L. Selenium and redox signaling[J]. Arch. Biochem. Biophys., 2017,617:48-59. doi: 10.1016/j.abb.2016.08.003
22. [22]
  Wong X Y, Sena-Torralba A, Álvarez-Diduk R, Muthoosamy K, Merkoçi A. Nanomaterials for nanotheranostics: Tuning their properties according to disease needs[J]. ACS Nano, 2020,14:2585-2627. doi: 10.1021/acsnano.9b08133
23. [23]
  Zhao D, Zhang R, Liu X M, Li X Y, Xu M Y, Huang X J, Xiao X C. Screening of chitosan derivatives-carbon dots based on antibacterial activity and application in anti-staphylococcus aureus biofilm[J]. Int. J. Nanomed., 2022,17:937-952. doi: 10.2147/IJN.S350739
24. [24]
  Yougbaré S, Chou H L, Yang C H, Krisnawati D I, Jazidie A, Nuh M, Kuo T R. Facet-dependent gold nanocrystals for effective photothermal killing of bacteria[J]. J. Hazard. Mater., 2021,407124617. doi: 10.1016/j.jhazmat.2020.124617
1. [1]
  Min Huang , Ru Cheng , Shuai Wen , Liangtong Li , Jie Gao , Xiaohui Zhao , Chunmei Li , Hongyan Zou , Jian Wang . Ultrasensitive detection of microRNA-21 in human serum based on the confinement effect enhanced chemical etching of gold nanorods. Chinese Chemical Letters, 2024, 35(9): 109379-. doi: 10.1016/j.cclet.2023.109379
2. [2]
  Meiling Xu , Xinyang Li , Pengyuan Liu , Junjun Liu , Xiao Han , Guodong Chai , Shuangling Zhong , Bai Yang , Liying Cui . A novel and visible ratiometric fluorescence determination of carbaryl based on red emissive carbon dots by a solvent-free method. Chinese Chemical Letters, 2025, 36(2): 109860-. doi: 10.1016/j.cclet.2024.109860
3. [3]
  Shipeng WANG , Shangyu XIE , Luxian LIANG , Xuehong WANG , Jie WEI , Deqiang WANG . Piezoelectric effect of Mn, Bi co-doped sodium niobate for promoting cell proliferation and bacteriostasis. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1919-1931. doi: 10.11862/CJIC.20240094
4. [4]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
5. [5]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
6. [6]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
7. [7]
  Xuehua SUN , Min MA , Jianting LIU , Rui TIAN , Hongmei CHAI , Huali CUI , Loujun GAO . Pr/N co-doped biomass carbon dots with enhanced fluorescence for efficient detection of 2,4-dinitrophenylhydrazine. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 561-573. doi: 10.11862/CJIC.20240294
8. [8]
  Yufeng Wu , Mingjun Jing , Juan Li , Wenhui Deng , Mingguang Yi , Zhanpeng Chen , Meixia Yang , Jinyang Wu , Xinkai Xu , Yanson Bai , Xiaoqing Zou , Tianjing Wu , Xianyou Wang . Collaborative integration of Fe-N_x active center into defective sulfur/selenium-doped carbon for efficient oxygen electrocatalysts in liquid and flexible Zn-air batteries. Chinese Chemical Letters, 2024, 35(9): 109269-. doi: 10.1016/j.cclet.2023.109269
9. [9]
  Fengkai Zou , Borui Su , Han Leng , Nini Xin , Shichao Jiang , Dan Wei , Mei Yang , Youhua Wang , Hongsong Fan . Red-emissive carbon quantum dots minimize phototoxicity for rapid and long-term lipid droplet monitoring. Chinese Chemical Letters, 2024, 35(10): 109523-. doi: 10.1016/j.cclet.2024.109523
10. [10]
  Fei Yin , Erli Yang , Xue Ge , Qian Sun , Fan Mo , Guoqiu Wu , Yanfei Shen . Coupling WO₃₋_x dots-encapsulated metal-organic frameworks and template-free branched polymerization for dual signal-amplified electrochemiluminescence biosensing. Chinese Chemical Letters, 2024, 35(4): 108753-. doi: 10.1016/j.cclet.2023.108753
11. [11]
  Yiyang Shen , Zhen Zhang , Ruyi Liang , Tongbo Wu . Unraveling the interplay of DNAzyme and interfacial factors for enhanced biosensing. Chinese Chemical Letters, 2024, 35(12): 109638-. doi: 10.1016/j.cclet.2024.109638
12. [12]
  Erzhuo Cheng , Yunyi Li , Wei Yuan , Wei Gong , Yanjun Cai , Yuan Gu , Yong Jiang , Yu Chen , Jingxi Zhang , Guangquan Mo , Bin Yang . Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing. Chinese Chemical Letters, 2024, 35(9): 109386-. doi: 10.1016/j.cclet.2023.109386
13. [13]
  Chuang LIU , Lichao SUN , Qingfeng ZHANG . Chiral inorganic nanocatalysts for electrochemical and enzyme-mimicked biosensing. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 59-78. doi: 10.11862/CJIC.20240406
14. [14]
  Rui Cheng , Xin Huang , Tingting Zhang , Jiazhuang Guo , Jian Yu , Su Chen . Solid superacid catalysts promote high-performance carbon dots with narrow-band fluorescence emission for luminescence solar concentrators. Chinese Chemical Letters, 2024, 35(8): 109278-. doi: 10.1016/j.cclet.2023.109278
15. [15]
  Jinjie Lu , Qikai Liu , Yuting Zhang , Yi Zhou , Yanbo Zhou . Antibacterial performance of cationic quaternary phosphonium-modified chitosan polymer in water. Chinese Chemical Letters, 2024, 35(9): 109406-. doi: 10.1016/j.cclet.2023.109406
16. [16]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
17. [17]
  Qihang Wu , Hui Wen , Wenhai Lin , Tingting Sun , Zhigang Xie . Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment. Chinese Chemical Letters, 2024, 35(12): 109692-. doi: 10.1016/j.cclet.2024.109692
18. [18]
  Fangping Yang , Jin Shi , Yuansong Wei , Qing Gao , Jingrui Shen , Lichen Yin , Haoyu Tang . Mixed-charge glycopolypeptides as antibacterial coatings with long-term activity. Chinese Chemical Letters, 2025, 36(2): 109746-. doi: 10.1016/j.cclet.2024.109746
19. [19]
  Chong Liu , Ling Li , Jiahui Gao , Yanwei Li , Nazhen Zhang , Jing Zang , Cong Liu , Zhaopei Guo , Yanhui Li , Huayu Tian . The study of antibacterial activity of cationic poly(β-amino ester) regulating by amphiphilic balance. Chinese Chemical Letters, 2025, 36(2): 110118-. doi: 10.1016/j.cclet.2024.110118
20. [20]
  Qiang Fu , Shouhong Sun , Kangzhi Lu , Ning Li , Zhanhua Dong . Boron-doped carbon dots: Doping strategies, performance effects, and applications. Chinese Chemical Letters, 2024, 35(7): 109136-. doi: 10.1016/j.cclet.2023.109136

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(535)
HTML views(67)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142