Citation: Pei-Pei DING, Ming LI, Yu WU, Jun-Tao YAN, Chun-Lei WANG, Yang WANG, Jia-Wei MAO. Synthesis, Crystal Structure, and DNA Binding/Cleavage Properties of a Macrocyclic Heterobinuclear Zn(Ⅱ)-Ni(Ⅱ) Complex with Pyridylmethyl Pendant-Arms[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(9): 1853-1861. doi: 10.11862/CJIC.2022.199 shu

Synthesis, Crystal Structure, and DNA Binding/Cleavage Properties of a Macrocyclic Heterobinuclear Zn(Ⅱ)-Ni(Ⅱ) Complex with Pyridylmethyl Pendant-Arms

Pei-Pei DING ¹ ,
Ming LI ² ,
Yu WU ² ,
Jun-Tao YAN ¹ ,
Chun-Lei WANG ¹ ,
Yang WANG ¹ ,
Jia-Wei MAO ^2,,

1.
School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China
2.
Institute of Product Quality Supervision and Inspection, Chengdu 610100, China

Corresponding author: Jia-Wei MAO, wyydcc@163.com
Received Date: 21 March 2022
Revised Date: 1 August 2022

Figures(7)

A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn(Ⅱ)-Ni(Ⅱ) complex [ZnNi(L)](ClO₄)₂·H₂O (H₂L=3, 3'-((ethane-1, 2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene)) bis(2-hydroxy-5-methylbenzaldehyde)) has been obtained and characterized by spectroscopy, elemental analysis and single-crystal X-ray diffraction. The coordination environment of Zn(Ⅱ) and Ni(Ⅱ) can be described as approximately distorted triangular prism and square pyramid, respectively. The Zn—Ni distance bridged by two phenoxide groups is 0.303 63(6) nm. The interaction between the complex and calf thymus DNA (CT-DNA) has been further confirmed by UV-Vis spectrophotometry, viscosity, and cyclic voltammetry study. The complex showed a good binding property to CT-DNA with a binding constant of 1.05×10⁵ L·mol^-1. The DNA cleavage activity has also been investigated using agarose gel electrophoresis.
- pendant-armed macrocyclic complex,
- crystal structure,
- coordination environment,
- DNA binding,
- DNA cleavage
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