Citation: Dian ZHU, Jun ZHANG, Qian ZHANG, Shu‐Qi LIANG, Ying XIONG, Yi‐Fan JIANG, Mei‐Fang WANG, Ju‐Yuan WEI, Xi‐Rui FAN, Zhi‐Jun FENG. Syntheses, Crystal Structures, and Antitumor Activities of Mn(Ⅱ) Complex and La(Ⅲ) Coordination Polymer with 2, 6‐Diacetylpyridine Salicylhydrazone Derivative[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(8): 1499-1511. doi: 10.11862/CJIC.2022.165 shu

Syntheses, Crystal Structures, and Antitumor Activities of Mn(Ⅱ) Complex and La(Ⅲ) Coordination Polymer with 2, 6‐Diacetylpyridine Salicylhydrazone Derivative

Dian ZHU ^{1, #} ,
Jun ZHANG ^{1, #} ,
Qian ZHANG ¹ ,
Shu‐Qi LIANG ¹ ,
Ying XIONG ¹ ,
Yi‐Fan JIANG ¹ ,
Mei‐Fang WANG ^{1, 2, 3} ,
Ju‐Yuan WEI ¹ ,
Xi‐Rui FAN ^4,, ,
Zhi‐Jun FENG ^{1, 2,,}

1.
School of Pharmacy, Wannan Medical College, Wuhu, Anhui 241002, China
2.
Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Normal University, Wuhu, Anhui 241002, China
3.
The Key Laboratory of Antiinflammatory and Immuune Medicine, Ministry of Education, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
4.
Department of Biochemistry, Wannan Medical College, Wuhu, Anhui 241002, China

Corresponding author: Xi‐Rui FAN, fengzhijun73@163.com Zhi‐Jun FENG, 1625834032@qq.com
Received Date: 23 January 2022
Revised Date: 10 May 2022

Figures(12)

Complex [MnH₂L(DMSO)₂] (1) and coordination polymer {[La(H₂L)₂]₂[La₂(H₂L)₂(DMF)₅(H₂O)] ·2DMF· 2H₂O}_n (2) (DMSO=dimethyl sulfoxide, DMF=N, N‐dimethylformamide) having 2, 6‐diacetylpyridine salicylhydrazone derivative (2, 6‐((o‐OH)C₆H₄C=ONHN=C(CH₃))₂C₅H₃N, H₄L) as ligand were synthesized and characterized by IR, UV‐Vis, elemental analysis and further by single‐crystal X‐ray diffraction. Complex 1 belongs to an orthorhombic crystal system with space group P2₁2₁2₁, and coordination polymer 2 crystallizes in a triclinic crystal system with space group P1. Moreover, the in vitro antitumor activities of complex 1 and coordination polymer 2 were evaluated by CCK‐8 assay in the colon (HCT116) and colorectal adenocarcinoma (DLD‐1) cancer cell lines. And the resulting IC₅₀ values were estimated to be as low as (23.69±1.226) μmol·L^-1 and (41.06±1.013) μmol·L^-1 for complex 1 or (57.61±1.034) μmol·L^-1 and (61.36±1.029) μmol·L^-1 for complex 2 against HCT116 and DLD‐1 cells, respectively, proving cytotoxic activities of complex 1 and coordination polymer 2 against these two cancer cell lines.
- manganese(Ⅱ) complex,
- lanthanum(Ⅲ) coordination polymer,
- 2, 6‐diacetylpyridine salicylhydrazone,
- crystal structure,
- antitumor activity
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