Citation: LI Tian-Le, ZHONG Hui, LI Xiao-Rong, ZHOU Jing, LIU Yi-Xin, HU Wei-Cheng, CHENG Zhi-Peng, YAO Cheng. Preparation and in Vitro Experiment of Attapulgite-based Microgels with Magnetic/Temperature Dual Sensitivities[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(1): 180-188. doi: 10.11862/CJIC.2021.017 shu

Preparation and in Vitro Experiment of Attapulgite-based Microgels with Magnetic/Temperature Dual Sensitivities

LI Tian-Le ^1,2 ,
ZHONG Hui ^1,2,, ,
LI Xiao-Rong ^2,, ,
ZHOU Jing ^3,4 ,
LIU Yi-Xin ² ,
HU Wei-Cheng ⁴ ,
CHENG Zhi-Peng ² ,
YAO Cheng ^1,,

1.
College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 210000, China
2.
Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian, Anhui 223300, China
3.
College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumchi 830001, China
4.
College of Life Science, Huaiyin Normal University, Huaian, Anhui 223300, China

Corresponding author: ZHONG Hui, huizhong@hytc.edu.cn LI Xiao-Rong, lxr206206@163.com YAO Cheng, yaocheng@njtech.edu.cn
Received Date: 8 July 2020
Revised Date: 12 November 2020

Figures(7)

The folic acid (FA)-grafted magnetic FA-Fe₃O₄/ATP-P(NIPAM-AAM) composite microgels (attapulgite=ATP, N-isopropyl acrylamide=NIPAM, acrylamide=AAM) were prepared via a method of emulsion copolymerization. The as-prepared microgels were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermogravimetric analysis (TG), infrared spectroscopy (IR), UV-visible spectroscopy (UV), scanning electron microscope (SEM) and transmission electron microscope (TEM). The dynamic light scattering (DLS) results show that the low critical solution temperature (LCST) of microgel was about 38.5℃. The drug delivery ability of the as-prepared microgels was evaluated by using doxorubicin hydrochloride (DOX) as the model drug. Based on the drug loading and releasing results, the presence of ATP increased the amount of drug loading and releasing. Compared with free DOX, the in vitro cytotoxicity of DOX loaded FA-Fe₃O₄/ATP-P(NIPAM-AAM) was decreased and the biocompatibility was improved. Those results indicate that the microgels of FA-Fe₃O₄/ATP-P(NIPAM-AAM) can be used in potential as a slow-release drug system. The in vitro cellular uptake test revealed that the microgels of FA-Fe₃O₄/ATP-P(NIPAM-AAM) at the assigned site were significantly richer than that of other sites. This result indicates that the microgels of FA-Fe₃O₄/ATP-P(NIPAM-AAM) composite are targeting and expectable in the application of targeted drug releasing.
- materials chemistry,
- magnetic nanocomposites,
- emulsion polymerization,
- attapulgite,
- temperature-sensitive,
- targeted,
- drug delivery
1. [1]
  Iyer A. K, Singh A, Ganta S, Amiji M M. Adv. Drug Delivery Rev., 2013, 65(13/14):1784-1802
2. [2]
  Jain K K. Methods Mol. Biol., 2008, 437:1-50
3. [3]
  Peng J, Zhang W L, Ai S L, Zhang Y H, Liu J Y, Liu J, He P X, Li Y. Nanotechnology, 2019, 30(11):115701 doi: 10.1088/1361-6528/aaf8e4
4. [4]
  Li R, Nie W, Yang W. Mater. Res. Express, 2019, 6(7):075048 doi: 10.1088/2053-1591/ab179e
5. [5]
  Hopkins S, Carter S. R, Haycock J W, Fullwood N J, MacNeil S, Rimmer S. Soft Matter, 2009, 5(19):3701-3712
6. [6]
  Matsune H, Ono T, Yoshida R, Yamamoto T, Kishida M. Chem. Lett., 2019, 48:1058-1060 doi: 10.1246/cl.190353
7. [7]
  Sakai K, Sawa M, Nomura K, Endo T, Tsuchiya K, Sakamoto K. Chem. Lett., 2016, 45:655-657 doi: 10.1246/cl.160231
8. [8]
  Motiei M, Dreifuss T, Sadan T, Omer N, Blumenfeld-Katzir T, Frago-georgi E. Chem. Lett., 2019, 48:291-294 doi: 10.1246/cl.180780
9. [9]
  Chen S J, Zhang Q Y, Gu J W, Ma M L, Zhang L, Zhou J, Zhou Y Y. Colloid. Polym. Sci., 2015, 290(12):1207-1213
10. [10]
  Xu G. Wu W T, Wang Y, Pang W, Lu F. Nanotechnology, 2006, 17(10):2458-2465
11. [11]
  Zhang K J, Zhou D, Wang Z G, Zhang Y H, He P X. Nanotechnology, 2019, 30(35):355604 doi: 10.1088/1361-6528/ab209d
12. [12]
  Li X M, Zhong H, Li X R, Jia F F, Cheng Z P, Zhang L L, Yin J Z, An L T, Guo L P. Mater. Sci. Eng. C, 2014, 45:170-175 doi: 10.1016/j.msec.2014.08.056
13. [13]
  Han Y, Chen H F, Chen D J. J. Mater. Sci., 2010, 45(9):2372-2380 doi: 10.1007/s10853-009-4203-3
14. [14]
  Wang D, Duan H, Lu J H, Lv C. J. Mater. Chem. A, 2017, 5(10):5088-5097 doi: 10.1039/C6TA09772C
15. [15]
  Lu Y J, Low P S. Adv. Drug Deliver. Rev., 2012, 54(5):342-352
16. [16]
  Sahoo S L, Liu C H, Wu W C. RSC Adv., 2017, 7:22468-22478 doi: 10.1039/C7RA02084H
17. [17]
  Dutta B, Nema A, Shetake N G, Gupta J, Hassan P A. Mater. Sci. Eng. C, 2020, 112:110915 doi: 10.1016/j.msec.2020.110915
18. [18]
  Yang P, Zeng H, Liu J. J. Mater. Chem. B, 2013, 1(39):5298-5308 doi: 10.1039/c3tb20975j
19. [19]
  Fu M, Zhang Z P. Mater. Lett., 2018, 226:43-46 doi: 10.1016/j.matlet.2018.04.128
20. [20]
  Kim Y H, Sim B, Choi H J. Colloids Surf. A, 2016, 507:103-109 doi: 10.1016/j.colsurfa.2016.07.095
21. [21]
  Zhao Y J, Chen Y, Li M S, Zhou S Y, Xue A L, Xing W H. J. Hazard Mater., 2009, 171(1/2/3):640-646
22. [22]
  Wang C N, Wang Y Y, Jin Y L, Xu T, Yuan L, Fang J H. J. Nanosci. Nanotechnol., 2015, 15(9):6784-6789 doi: 10.1166/jnn.2015.11111
23. [23]
  Han H D, Shin B C, Choi H S. Eur. J. Pharm. Biopharm., 2006, 62(1):110-116
24. [24]
  Jo A, Lim D, Kim H. Sci. Rep., 2017, 7:41090 doi: 10.1038/srep41090
25. [25]
  Ma C B, Shi Y, Pena D A, Peng L L, Yu G H. Angew. Chem., 2015, 127(25):7484-7488 doi: 10.1002/ange.201501705
26. [26]
  Chen Y, Chen Y B, Nan J Y, Wang C, Chu F. J. Appl. Polym. Sci., 2012, 124(6):4678-4685
27. [27]
  Li A H, Ma H J, Feng S Y, Liu J. RSC Adv., 2016, 6(39):33138-33147 doi: 10.1039/C5RA27839B
28. [28]
  Zhang J, Jiang Y, Li Y, Li W, Hu W. Carbohydr. Polym., 2019, 230:115576
1. [1]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
2. [2]
  Junfei Yang , Ke Wang , Shuxin Sun , Tianqi Pei , Junxiu Li , Xunwei Gong , Cuixia Zheng , Yun Zhang , Qingling Song , Lei Wang . A "spore-like" oral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease. Chinese Chemical Letters, 2025, 36(3): 110180-. doi: 10.1016/j.cclet.2024.110180
3. [3]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
4. [4]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
5. [5]
  Kailong Zhang , Chao Zhang , Luanhui Wu , Qidong Yang , Jiadong Zhang , Guang Hu , Liang Song , Gaoran Li , Wenlong Cai . Chloride molten salt derived attapulgite with ground-breaking electrochemical performance. Chinese Chemical Letters, 2024, 35(10): 109618-. doi: 10.1016/j.cclet.2024.109618
6. [6]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
7. [7]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
8. [8]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
9. [9]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
10. [10]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
11. [11]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
12. [12]
  Mengyuan Li , Xitong Ren , Yanmei Gao , Mengyao Mu , Shiping Zhu , Shufang Tian , Minghua Lu . Constructing bifunctional magnetic porous poly(divinylbenzene) polymer for high-efficient removal and sensitive detection of bisphenols. Chinese Chemical Letters, 2024, 35(12): 109699-. doi: 10.1016/j.cclet.2024.109699
13. [13]
  Haijun Shen , Yi Qiao , Chun Zhang , Yane Ma , Jialing Chen , Yingying Cao , Wenna Zheng . A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing. Chinese Chemical Letters, 2024, 35(12): 110283-. doi: 10.1016/j.cclet.2024.110283
14. [14]
  Shuangying Li , Qingxiang Zhou , Zhi Li , Menghua Liu , Yanhui Li . Sensitive measurement of silver ions in environmental water samples integrating magnetic ion-imprinted solid phase extraction and carbon dot fluorescent sensor. Chinese Chemical Letters, 2024, 35(5): 108693-. doi: 10.1016/j.cclet.2023.108693
15. [15]
  Jiayin Zhou , Depeng Liu , Longqiang Li , Min Qi , Guangqiang Yin , Tao Chen . Responsive organic room-temperature phosphorescence materials for spatial-time-resolved anti-counterfeiting. Chinese Chemical Letters, 2024, 35(11): 109929-. doi: 10.1016/j.cclet.2024.109929
16. [16]
  Chao Zhang , Ai-Feng Liu , Shihui Li , Fang-Yuan Chen , Jun-Tao Zhang , Fang-Xing Zeng , Hui-Chuan Feng , Ping Wang , Wen-Chao Geng , Chuan-Rui Ma , Dong-Sheng Guo . A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy. Chinese Chemical Letters, 2025, 36(1): 109752-. doi: 10.1016/j.cclet.2024.109752
17. [17]
  Botao QU , Qian WANG , Xiaogang NING , Yuxin ZHOU , Ruiping ZHANG . Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 1025-1032. doi: 10.11862/CJIC.20230416
18. [18]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
19. [19]
  Bin Fang , Jiaqi Yang , Limin Wang , Haoqin Li , Jiaying Guo , Jiaxin Zhang , Qingyuan Guo , Bo Peng , Kedi Liu , Miaomiao Xi , Hua Bai , Li Fu , Lin Li . A mitochondria-targeted H₂S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury. Chinese Chemical Letters, 2024, 35(6): 108913-. doi: 10.1016/j.cclet.2023.108913
20. [20]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946

Get Citation

PDF

XML

Metrics

PDF Downloads(11)
Abstract views(1302)
HTML views(257)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142