Citation: LI Zhen-Hua, YUAN Wei, LI Fu-You. Triple-Triplet Annihilation Upconversion Nanocapsules for in Vivo Bioimaging[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(10): 1934-1940. doi: 10.11862/CJIC.2020.211 shu

Triple-Triplet Annihilation Upconversion Nanocapsules for in Vivo Bioimaging

Department of Chemistry, Fudan University, Shanghai 200433, China

Corresponding author: YUAN Wei, yuanwei@fudan.edu.cn LI Fu-You, fyli@fudan.edu.cn
Received Date: 23 May 2020
Revised Date: 31 May 2020

Figures(8)

To solve the problem that it is difficult to immobilize triple-triplet annihilation based upconversion (TTAUC) for biological application, water soluble nanocapsules with n-hexadecane core containing a TTA-UC system were synthesized by a one-step miniemulsion polymerization. In the TTA-UC system, silicon phthalocyanine excited by red light source as sensitizer and rubrene with high efficiency as receptor were introduced into n-hexadecane to endow the nanocapsules with upconversion emission. The TTA-UC nanocapsules (TT-UCNP) have a typical coreshell structure with a uniform size of 190 nm. To eliminate the quenching effect of molecular oxygen on upconversion luminescence, D-limonene and polyisobutylene were selected as anti-oxidant, and the TTA-UCNP showed bright upconversion emission. The TTA-UCNP have been successfully applied in in vivo imaging of sentinel lymph node (SLN) with high signal-to-noise ratio and long-term tracing.
- upconverted luminescence,
- bioimaging,
- triple-triplet annihilation,
- miniemulsion polymerization
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