Citation: CHEN Hong-Ming, TANG Xiao-Xue, LIN Ya-Ying, GONG Xuan-Qing, LIN Hong-Yu, GAO Jin-Hao. A Ca²⁺-Responsive ¹H/¹⁹F MRI Molecular Probe Based on Competitive Coordination[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(6): 1072-1078. doi: 10.11862/CJIC.2020.133 shu

A Ca²⁺-Responsive ¹H/¹⁹F MRI Molecular Probe Based on Competitive Coordination

The MOE Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China

Corresponding author: GAO Jin-Hao, jhgao@xmu.edu.cn
Received Date: 13 March 2020
Revised Date: 22 April 2020

Figures(7)

Herein, we report a complex manganese(Ⅱ) 3, 12-bis(2-oxo-2-((2, 2, 2-trifluoroethyl)amino)ethyl), 9-dioxa-3, 12-diazatetradecanediate (Mn(Ⅱ)-L, 1) as a Ca²⁺-responsive ¹H/¹⁹F magnetic resonance imaging (MRI) molecular probe. Transversal relaxation time T₂ of ¹⁹F nuclei is shortened dramatically by the paramagnetic relaxation enhancement (PRE) effect imposed by paramagnetic Mn²⁺ ions, resulting in significantly decreased ¹⁹F MRI signals. Mn²⁺ ions can be specifically replaced by Ca²⁺ ions via competitive coordination, leading to the increased distance between Mn²⁺ ions and ¹⁹F nuclei and the recovery of ¹⁹F MRI signals. At the same time, the higher longitudinal relaxivity r₁ of free Mn²⁺ ions also brings about brighter ¹H MRI signals. As demonstrated by our experiments, this complex is a Ca²⁺-responsive molecular probe for ¹H/¹⁹F MRI.
- fluorinated ligands,
- NMR spectroscopy,
- calcium,
- manganese,
- magnetic resonance imaging (MRI),
- ¹H/¹⁹F MRI probe,
- paramagnetic relaxation enhancement (PRE),
- competitive coordination
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通讯作者: 陈斌, bchen63@163.com

A Ca²⁺-Responsive ¹H/¹⁹F MRI Molecular Probe Based on Competitive Coordination