Citation: LI Ze-Ran, ZHU Jian-Ping, YU Han-Yang, CHEN Yun-Cong, HE Wei-Jiang, GUO Zi-Jian. Construction and Fe²⁺ Sensing of a Chelation Based Fe²⁺ Probe[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(11): 2031-2037. doi: 10.11862/CJIC.2019.223 shu

Construction and Fe²⁺ Sensing of a Chelation Based Fe²⁺ Probe

1.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
2.
College of Engineering and Applied Sciences, Nanjing University, Nanjing 210008, China

Corresponding author: CHEN Yun-Cong, chenyc@nju.edu.cn GUO Zi-Jian, zguo@nju.edu.cn
Received Date: 23 May 2019
Revised Date: 24 June 2019

Figures(10)

Iron is the most abundant essential transition metal in human body, and iron disorder has been reported to be associated with many diseases. Therefore, the development of fluorescent probes for Fe²⁺/Fe³⁺ imaging and offering spatial-temporal information of Fe²⁺/Fe³⁺ is of great significance. We chose BODIPY with good stability and high quantum yield as the fluorophore, and the terpyridine with high binding ability to Fe²⁺ as a chelating group. The probe BTPY for Fe²⁺ was constructed by integrating BODIPY with terpyridine at α-position by a vinyl group to form a large conjugated system. The NIR emission at 678 nm and the visible excitation at 582 nm suggest that this probe has the potential for in vivo imaging in animal model. BTPY was able to selectively bind Fe²⁺/Fe³⁺ with a bathochromic absorption shift from 573 to 607 nm and the solution color changed from red to pale blue. In addition, Fe²⁺ caused BTPY fluorescence quenching while Fe³⁺ did not significantly affect the fluorescence. Combining with the spectra change of absorption and emission, this probe can be used for visual detection of iron ions and is able to distinguish Fe²⁺ from Fe³⁺.
- iron ions,
- chelating probe,
- visual detection
1. [1]
  Lippard S J, Berg J M. Principles of Bioinorganic Chemistry. Mill Valley:University Science Books, 1994:142
2. [2]
  Domaille D M, Que E L, Chang C J. Nat. Chem. Biol., 2008, 4:168-175 doi: 10.1038/nchembio.69
3. [3]
  Aisen P, Wessling-Resnick M, Leibold E A. Curr. Opin. Chem. Biol., 1999, 3:200-206 doi: 10.1016/S1367-5931(99)80033-7
4. [4]
  Costas M, Mehn M P, Jensen M P, et al. Chem. Rev., 2004, 104:939-986 doi: 10.1021/cr020628n
5. [5]
  Rouault T A, Tong W H. Nat. Rev. Mol. Cell Biol., 2005, 6:345-351
6. [6]
  Wilson M T, Reeder B J. Exp. Physiol., 2008, 93:128-132 doi: 10.1113/expphysiol.2007.039735
7. [7]
  Halliwell B, Gutteridge J M C. FEBS Lett., 1992, 307:108-112 doi: 10.1016/0014-5793(92)80911-Y
8. [8]
  Xu J, Jia Z, Knutson M D, et al. Int. J. Mol. Sci., 2012, 13:2368-2386 doi: 10.3390/ijms13022368
9. [9]
  Richardson D R, Lane D J R, Becker E M, et al. Proc. Natl. Acad. Sci. U.S.A., 2010, 107:10775-10782 doi: 10.1073/pnas.0912925107
10. [10]
  Breuer W, Shvartsman M, Cabantchik Z I. Int. J. Biochem. Cell Biol., 2008, 40:350-354 doi: 10.1016/j.biocel.2007.03.010
11. [11]
  Petrat F, de Groot H, Rauen U. Biochem. J., 2001, 356:61-69 doi: 10.1042/bj3560061
12. [12]
  Hirayama T, Okuda K, Nagasawa H. Chem. Sci., 2013, 4:1250-1256 doi: 10.1039/c2sc21649c
13. [13]
  Niwa M, Hirayama T, Okuda K, et al. Org. Biomol. Chem., 2014, 12:6590-6597 doi: 10.1039/C4OB00935E
14. [14]
  Hou G G, Wang C H, Sun J F, et al. Biochem. Biophys. Res. Commun., 2013, 439:459-463 doi: 10.1016/j.bbrc.2013.08.092
15. [15]
  Xuan W M, Pan R, Wei Y Y, et al. Bioconjugate Chem., 2016, 27:302-308 doi: 10.1021/acs.bioconjchem.5b00259
16. [16]
  CHEN Sheng-Tian, ZHANG Yu, ZHAO Jian-Ying, et al. Chinese J. Inorg. Chem., 2019, 35(4):737-744
17. [17]
  Panda S, Pati P B, Zade S S. Chem. Commun., 2011, 47:4174-4176 doi: 10.1039/c1cc10425j
18. [18]
  Au-Yeung H Y, Chan J, Chantarojsiri T, et al. J. Am. Chem. Soc., 2013, 135:15165-15173 doi: 10.1021/ja4072964
19. [19]
  Ziessel R, Ulrich G, Harriman A. New J. Chem., 2007, 31:496-501 doi: 10.1039/b617972j
20. [20]
  Boens N, Leen V, Dehaen W. Chem. Soc. Rev., 2012, 41:1130-1172 doi: 10.1039/C1CS15132K
21. [21]
  QU Xing-Yu, BIAN Yong-Jun, BAI Yang, et al. Chinese J. Inorg. Chem., 2019, 35(4):649-657
22. [22]
  Hu Z J, Yang J X, Tian Y P, et al. Bull. Chem. Soc. Jpn., 2007, 80:986-993 doi: 10.1246/bcsj.80.986
23. [23]
  Tan Y Q, Liu M, Gao J K, et al. Dalton Trans., 2014, 43:8048-8053 doi: 10.1039/C4DT00167B
24. [24]
  Wang M Z, Zhang Y Y, Wang T, et al. Org. Lett., 2016, 18:1976-1979 doi: 10.1021/acs.orglett.6b00547
1. [1]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
2. [2]
  Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
3. [3]
  Yingpeng ZHANG , Xingxing LI , Yunshang YANG , Zhidong TENG . A pyrazole-based turn-off fluorescent probe for visual detection of hydrazine. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1301-1308. doi: 10.11862/CJIC.20250064
4. [4]
  Yuan ZHU , Xiaoda ZHANG , Shasha WANG , Peng WEI , Tao YI . Conditionally restricted fluorescent probe for Fe³⁺ and Cu²⁺ based on the naphthalimide structure. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 183-192. doi: 10.11862/CJIC.20240232
5. [5]
  Wenyan Dan , Weijie Li , Xiaogang Wang . The Technical Analysis of Visual Software ShelXle for Refinement of Small Molecular Crystal Structure. University Chemistry, 2024, 39(3): 63-69. doi: 10.3866/PKU.DXHX202302060
6. [6]
  Yanxin Wang , Hongjuan Wang , Yuren Shi , Yunxia Yang . Application of Python for Visualizing in Structural Chemistry Teaching. University Chemistry, 2024, 39(3): 108-117. doi: 10.3866/PKU.DXHX202306005
7. [7]
  Ruming Yuan , Laiying Zhang , Xiaoming Xu , Pingping Wu , Gang Fu . Application of Mathematica in Visualizing Physical Chemistry Formulas. University Chemistry, 2024, 39(8): 375-382. doi: 10.3866/PKU.DXHX202401030
8. [8]
  Longping Li , Jiali Li , Tiange Qu , Jiaqing Cai , Chuyu Zhang , Wenji Guo , Qiulian Li , Fan Luo . “可视化”助力从茶叶中提取咖啡因实验的关键步——升华. University Chemistry, 2025, 40(8): 272-276. doi: 10.12461/PKU.DXHX202409137
9. [9]
  Yiying Yang , Rongxiu Zhu , Yuchen Ma , Dongju Zhang . MATLAB-based Visualization of Hydrogen-Like Orbitals and Analysis of Relavant Teaching Problems. University Chemistry, 2025, 40(9): 375-382. doi: 10.12461/PKU.DXHX202411015
10. [10]
  Ying Yang , Yonghan Wu , Zixuan Li , Lu Zhang , Rongqin Lin , Yefan Zhang , Jiquan Liu , Xiaohui Ning , Yan Li , Bin Cui . Visualization Simulation Experiment of Cyclic Voltammetry (CV) Based on Python. University Chemistry, 2025, 40(10): 233-242. doi: 10.12461/PKU.DXHX202412024
11. [11]
  Lijun Yang . Thoughts and Practices on Enhancing Students’ Comprehension through Visualized Instruction of Structural Chemistry. University Chemistry, 2025, 40(10): 295-302. doi: 10.12461/PKU.DXHX202411048
12. [12]
  Yuyao Wang , Zhitao Cao , Zeyu Du , Xinxin Cao , Shuquan Liang . Research Progress of Iron-based Polyanionic Cathode Materials for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100035-0. doi: 10.3866/PKU.WHXB202406014
13. [13]
  Yi Fan , Zhuoqi Jiang , Zhipeng Li , Xuan Zhou , Jingan Lin , Laiying Zhang , Xu Hou . 偶极诱导液体门控可视化物质检测——化学“101计划”表界面性质应用实验新设计. University Chemistry, 2025, 40(8): 265-271. doi: 10.12461/PKU.DXHX202410061
14. [14]
  Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu³⁺ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
15. [15]
  Zhenli Sun , Ning Wang , Kexin Lin , Qin Dai , Yufei Zhou , Dandan Cao , Yanfeng Dang . Visual Analysis of Hotspots and Development Trends in Analytical Chemistry Education Reform. University Chemistry, 2024, 39(11): 57-64. doi: 10.12461/PKU.DXHX202403095
16. [16]
  Zijuan LI , Xuan LÜ , Jiaojiao CHEN , Haiyang ZHAO , Shuo SUN , Zhiwu ZHANG , Jianlong ZHANG , Yanling MA , Jie LI , Zixian FENG , Jiahui LIU . Synthesis of visual fluorescence emission CdSe nanocrystals based on ligand regulation. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 308-320. doi: 10.11862/CJIC.20240138
17. [17]
  Wenhui Li , Changshuo Zhu , Xinyu Cui , Chenfei Zhao , Lina Qiu , Yan Li , Chuandong Wu , Min Yang , Yuan Zhuang . Visual Determination of Acid-Base Titration Endpoints Using Smartphone APP-Based Analysis. University Chemistry, 2025, 40(7): 328-335. doi: 10.12461/PKU.DXHX202409062
18. [18]
  Wenke ZHENG , Ce LIU , Wei CHEN , Hongshan KE , Fanlong ZENG , Yibo LEI , Anyang LI , Wenyuan WANG . Synthesis and bonding analysis of low-coordinate Fe and Cr complexes with ultra-bulky silylamino groups. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1285-1293. doi: 10.11862/CJIC.20250095
19. [19]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
20. [20]
  Huiying Xu , Minghui Liang , Zhi Zhou , Hui Gao , Wei Yi . Application of Quantum Chemistry Computation and Visual Analysis in Teaching of Weak Interactions. University Chemistry, 2025, 40(3): 199-205. doi: 10.12461/PKU.DXHX202407011

Get Citation

PDF

XML

Metrics

PDF Downloads(9)
Abstract views(2302)
HTML views(341)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Construction and Fe2+ Sensing of a Chelation Based Fe2+ Probe

Metrics

通讯作者: 陈斌, bchen63@163.com

Construction and Fe²⁺ Sensing of a Chelation Based Fe²⁺ Probe