Citation: LI Ji, HAO Yuan-Yuan, QIAN Yong, XUE Xu-Lin, SU Zhi, LIU Hong-Ke. DNA Targeting Rigid Dinuclear Ruthenium-Arene Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(8): 1500-1508. doi: 10.11862/CJIC.2019.184 shu

DNA Targeting Rigid Dinuclear Ruthenium-Arene Complexes

LI Ji ¹ ,
HAO Yuan-Yuan ¹ ,
QIAN Yong ¹ ,
XUE Xu-Lin ¹ ,
SU Zhi ^1,, ,
LIU Hong-Ke ^1,2,,

1.
College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China
2.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: SU Zhi, liuhongke@njnu.edu.cn LIU Hong-Ke, zhisu@njnu.edu.cn
Received Date: 30 March 2019
Revised Date: 15 May 2019

Figures(5)

Three dinuclear Ru(Ⅱ)-arene complexes[Ru₂(η⁶-p-bip)₂(1, 3-bib)₂XY]X₂ (X=Y=Cl^- (1), X=Y=Br^- (2), X=I^- and Y=Cl^- (3); 1, 3-bib=1, 3-di(1H-imidazol-1-yl)benzene, p-bip=biphenyl) were synthesized and fully characterized by ¹H NMR and ESI-MS. Single crystal X-ray diffractions studies showed that complex 1 owns a rigid M₂L₂ bowl-like structure, where one Cl^- is trapped inside the cavity to balance the charge. Complex 3 showed the best anticancer activities among complexes 1~3. The IC₅₀ value of 3 towards to human lung cancer cells (A549) reached to 13.9 μmol·L^-1, which is comparable to that of cisplatin (IC₅₀=15.2 μmol·L^-1). Complexes 1~3 have shown strong interactions with DNA and could induce the unwinding of the DNA superhelix structure.
- Ru-arene complexes,
- crystal structure,
- anticancer activity,
- interaction with DNA
1. [1]
  Wang X, Wang X, Jin S, et al. Chem. Rev., 2019, 119(2):1138-1192
2. [2]
  Bergamo A, Dyson P J, Sava G. Coord. Chem. Rev., 2018, 360:17-33 doi: 10.1016/j.ccr.2018.01.009
3. [3]
  Johnstone T C, Suntharalingam K, Lippard S J. Chem. Rev., 2016, 116(5):3436-3486 doi: 10.1021/acs.chemrev.5b00597
4. [4]
  Zeng L, Gupta P, Chen Y, et al. Chem. Soc. Rev., 2017, 46(19):5771-5804 doi: 10.1039/C7CS00195A
5. [5]
  Liu H K, Kostrhunova H, Habtemariam A, et al. Dalton Trans., 2016, 45(46):18676-18688 doi: 10.1039/C6DT03356C
6. [6]
  Fu Y, Romero M J, Salassa L, et al. Angew. Chem. Int. Ed., 2016, 55(31):8909-8912 doi: 10.1002/anie.201602995
7. [7]
  Davey G E, Adhireksan Z, Ma Z, et al. Nat. Commun., 2017, 8:1575 doi: 10.1038/s41467-017-01680-4
8. [8]
  Wu Q, Liu L Y, Li S, et al. J. Inorg. Biochem., 2018, 189:30-39 doi: 10.1016/j.jinorgbio.2018.08.013
9. [9]
  Coverdale J P C, Bridgewater H E, Song J I, et al. J. Med. Chem., 2018, 61(20):9246-9255 doi: 10.1021/acs.jmedchem.8b00958
10. [10]
  Liu H K, Sadler P J. Acc. Chem. Res., 2011, 44(5):349-359 doi: 10.1021/ar100140e
11. [11]
  Peacock A F A, Habtemariam A, Fernandez R, et al. J. Am. Chem. Soc., 2006, 128(5):1739-1748 doi: 10.1021/ja055886r
12. [12]
  Tronnier A, Strassner T. Dalton Trans., 2013, 42(27):9847-9851 doi: 10.1039/c3dt50841b
13. [13]
  ZHANG Fu-Xing, HE Tang-Feng, YAO Shu-Fen, et al. Chinese J. Inorg. Chem., 2019, 35(4):598-604
14. [14]
  Sheldrick G M. Acta Crystallogr. Sect. A:Found. Crystallogr., 2015, A71:3-8
15. [15]
  Guan R, Chen Y, Zeng L, et al. Chem. Sci., 2018, 9(23):5183-5190 doi: 10.1039/C8SC01142G
16. [16]
  GAO Aan-Li, XIONG Qing-Feng, JIANG Jing, et al. Chinese J. Inorg. Chem., 2018, 34(9):1649-1654
17. [17]
  Kumar C V, Barton J K, Turro N J. J. Am. Chem. Soc., 1985, 107(19):5518-5523 doi: 10.1021/ja00305a032
18. [18]
  MO Hui-Wen, LIU Ya-Xian, CAI Dai-Hong, et al. Chinese J. Inorg. Chem., 2019, 35(3):477-484
19. [19]
  Wang H Y, Qian Y, Wang F X, et al. Eur. J. Inorg. Chem., 2017(12):1792-1799
20. [20]
  Li J, Zhang P, Xu Y, et al. Dalton Trans., 2017, 46(46):16205-16215 doi: 10.1039/C7DT03374E
21. [21]
  Clavel C M, Paunescu E, Nowak-Sliwinska P, et al. Chem. Sci., 2014, 5(3):1097-1101 doi: 10.1039/c3sc53185f
22. [22]
  Murray B S, Menin L, Scopelliti R, et al. Chem. Sci., 2014, 5(6):2536-2545 doi: 10.1039/c4sc00116h
23. [23]
  Jeyalakshmi K, Haribabu J, Balachandran C, et al. Organo-metallics, 2019, 38(4):753-770 doi: 10.1021/acs.organomet.8b00702
24. [24]
  Zhou W, Wang X, Hu M, et al. Chem. Sci., 2014, 5(7):2761-2770 doi: 10.1039/C4SC00384E
25. [25]
  Li J, Tian M, Tian Z, et al. Inorg. Chem., 2018, 57(4):1705-1716 doi: 10.1021/acs.inorgchem.7b01959
26. [26]
  Karidi K, Garoufis A, Hadjiliadis N, et al. Dalton Trans., 2005(4):728-734 doi: 10.1039/b410402a
27. [27]
  Zhu Z, Wang X, Li T, et al. Angew. Chem. Int. Ed., 2014, 53(48):13225-13228 doi: 10.1002/anie.201407406
28. [28]
  Keck M V, Lippard S J. Tetrahedron Lett., 1993, 34(9):1415-1416 doi: 10.1016/S0040-4039(00)60306-4
1. [1]
  Yao HUANG , Yingshu WU , Zhichun BAO , Yue HUANG , Shangfeng TANG , Ruixue LIU , Yancheng LIU , Hong LIANG . Copper complexes of anthrahydrazone bearing pyridyl side chain: Synthesis, crystal structure, anticancer activity, and DNA binding. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 213-224. doi: 10.11862/CJIC.20240359
2. [2]
  Jia JI , Zhaoyang GUO , Wenni LEI , Jiawei ZHENG , Haorong QIN , Jiahong YAN , Yinling HOU , Xiaoyan XIN , Wenmin WANG . Two dinuclear Gd(Ⅲ)-based complexes constructed by a multidentate diacylhydrazone ligand: Crystal structure, magnetocaloric effect, and biological activity. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 761-772. doi: 10.11862/CJIC.20240344
3. [3]
  Chao LIU , Jiang WU , Zhaolei JIN . Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1986-1994. doi: 10.11862/CJIC.20240153
4. [4]
  Kaimin WANG , Xiong GU , Na DENG , Hongmei YU , Yanqin YE , Yulu MA . Synthesis, structure, fluorescence properties, and Hirshfeld surface analysis of three Zn(Ⅱ)/Cu(Ⅱ) complexes based on 5-(dimethylamino) isophthalic acid. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1397-1408. doi: 10.11862/CJIC.20240009
5. [5]
  Lu LIU , Huijie WANG , Haitong WANG , Ying LI . Crystal structure of a two-dimensional Cd(Ⅱ) complex and its fluorescence recognition of p-nitrophenol, tetracycline, 2, 6-dichloro-4-nitroaniline. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1180-1188. doi: 10.11862/CJIC.20230489
6. [6]
  Lulu DONG , Jie LIU , Hua YANG , Yupei FU , Hongli LIU , Xiaoli CHEN , Huali CUI , Lin LIU , Jijiang WANG . Synthesis, crystal structure, and fluorescence properties of Cd-based complex with pcu topology. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 809-820. doi: 10.11862/CJIC.20240171
7. [7]
  Xiumei LI , Yanju HUANG , Bo LIU , Yaru PAN . Syntheses, crystal structures, and quantum chemistry calculation of two Ni(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2031-2039. doi: 10.11862/CJIC.20240109
8. [8]
  Xiumei LI , Linlin LI , Bo LIU , Yaru PAN . Syntheses, crystal structures, and characterizations of two cadmium(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 613-623. doi: 10.11862/CJIC.20240273
9. [9]
  Xiaoxia WANG , Ya'nan GUO , Feng SU , Chun HAN , Long SUN . Synthesis, structure, and electrocatalytic oxygen reduction reaction properties of metal antimony-based chalcogenide clusters. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1201-1208. doi: 10.11862/CJIC.20230478
10. [10]
  Xiaoling WANG , Hongwu ZHANG , Daofu LIU . Synthesis, structure, and magnetic property of a cobalt(Ⅱ) complex based on pyridyl-substituted imino nitroxide radical. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 407-412. doi: 10.11862/CJIC.20240214
11. [11]
  Yan XU , Suzhi LI , Yan LI , Lushun FENG , Wentao SUN , Xinxing LI . Structure variation of cadmium naphthalene-diphosphonates with the changing rigidity of N-donor auxiliary ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 395-406. doi: 10.11862/CJIC.20240226
12. [12]
  Huan ZHANG , Jijiang WANG , Guang FAN , Long TANG , Erlin YUE , Chao BAI , Xiao WANG , Yuqi ZHANG . A highly stable cadmium(Ⅱ) metal-organic framework for detecting tetracycline and p-nitrophenol. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 646-654. doi: 10.11862/CJIC.20230291
13. [13]
  Ruikui YAN , Xiaoli CHEN , Miao CAI , Jing REN , Huali CUI , Hua YANG , Jijiang WANG . Design, synthesis, and fluorescence sensing performance of highly sensitive and multi-response lanthanide metal-organic frameworks. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 834-848. doi: 10.11862/CJIC.20230301
14. [14]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
15. [15]
  Shuyan ZHAO . Field-induced Co^Ⅱ single-ion magnet with pentagonal bipyramidal configuration. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1583-1591. doi: 10.11862/CJIC.20240231
16. [16]
  Yinling HOU , Jia JI , Hong YU , Xiaoyun BIAN , Xiaofen GUAN , Jing QIU , Shuyi REN , Ming FANG . A rhombic Dy₄-based complex showing remarkable single-molecule magnet behavior. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 605-612. doi: 10.11862/CJIC.20240251
17. [17]
  Xiaofen GUAN , Yating LIU , Jia LI , Yiwen HU , Haiyuan DING , Yuanjing SHI , Zhiqiang WANG , Wenmin WANG . Synthesis, crystal structure, and DNA-binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2486-2496. doi: 10.11862/CJIC.20240122
18. [18]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
19. [19]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
20. [20]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(775)
HTML views(41)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142