Citation: LÜ Mu-Xuan, BIAN Lin-Yan, LI Meng-Ru, YANG Yi, WU Wei-Na, WANG Yuan, CHEN Zhong. Three Cu(Ⅱ) Complexes with 1-(3-Ethylpyrazin-2-yl)ethylidene)-4-methylthiosemicarbazide: Crystal Structures and DNA-Binding Properties[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(8): 1463-1469. doi: 10.11862/CJIC.2019.169 shu

Three Cu(Ⅱ) Complexes with 1-(3-Ethylpyrazin-2-yl)ethylidene)-4-methylthiosemicarbazide: Crystal Structures and DNA-Binding Properties

LÜ Mu-Xuan ¹ ,
BIAN Lin-Yan ^1,, ,
LI Meng-Ru ¹ ,
YANG Yi ¹ ,
WU Wei-Na ^1,, ,
WANG Yuan ¹ ,
CHEN Zhong ²

1.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo, Henan 454000, China
2.
School of Materials and Mechanical and Electrical Engineering, Jiangxi Science and Technology Normal University, Nanchang 330013, China

Corresponding author: BIAN Lin-Yan, bianlinyan@hpu.edu.cn WU Wei-Na, wuwn08@hpu.edu.cn
Received Date: 13 December 2018
Revised Date: 20 May 2019

Figures(4)

Three Cu(Ⅱ) complexes, [Cu(L)Br]·DMF (1), [Cu(L)Cl]·2H₂O (2), and [Cu₂(L)₂(SO₄)]·H₂O·CH₃OH (3) (HL=1-(3-ethylpyrazin-2-yl)ethylidene)-4-methylthiosemicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction. The results show that the Cu(Ⅱ) ion in 1 and 2 is surrounded by one anionic thiosemicarbazone ligand with N₂S donor set and one halide ion (bromide for 1 and chloride for 2), thus giving a distorted planar square coordination geometry. However, in the dimeric complex 3, two Cu(Ⅱ) ions were doubly bridged by two S atoms of two TSC ligands to form a Cu₂S₂ core with Cu…Cu distance of 0.318 0 nm. Each of the Cu(Ⅱ) ions is also coordinated by two nitrogen atoms from one TSC ligand and one oxygen atom from the η²-SO₄^2- at the outer axial site, with a distorted square pyramid coordination geometry. Moreover, the fluorescence spectra indicate that the interactions of the complexes with DNA are stronger than that of the thiosemicarbazone ligand.
- complex,
- crystal structure,
- Cu(Ⅱ),
- pyrazine,
- thiosemicarbazone,
- DNA-binding property
1. [1]
  Li M X, Zhang L Z, Yang M, et al. Bioorg. Med. Chem. Lett., 2012, 22:2418-2433 doi: 10.1016/j.bmcl.2012.02.024
2. [2]
  Li M X, Zhang L Z, Zhang D, et al. Eur. J. Med. Chem., 2011, 46:4383-4390 doi: 10.1016/j.ejmech.2011.07.009
3. [3]
  Qi J, Deng J, Qian K, et al. Eur. J. Med. Chem., 2017, 134:34-42 doi: 10.1016/j.ejmech.2017.04.009
4. [4]
  Rogolino D, Cavazzoni A, Gatti A, et al. Eur. J. Med. Chem., 2017, 128:140-153 doi: 10.1016/j.ejmech.2017.01.031
5. [5]
  Erxleben A. Coord. Chem. Rev., 2018, 360:92-121 doi: 10.1016/j.ccr.2018.01.008
6. [6]
  Dubey P, Gupta S, Singh A K, et al. Dalton Trans., 2018, 47:3746-3774
7. [7]
  Zhang X M, Guo H, Li Z S, et al. Eur. J. Med. Chem., 2015, 101:419-430 doi: 10.1016/j.ejmech.2015.06.047
8. [8]
  Sangeetha K G, Aravindakshan K K. Inorg. Chim. Acta, 2018, 469:387-396 doi: 10.1016/j.ica.2017.09.057
9. [9]
  Milunovic M N M, Dobrova A, Novitchi G, et al. Eur. J. Inorg. Chem., 2017, 469:4473-4483
10. [10]
  Wang Y T, Fang Y, Zhao M, et al. MedChemComm, 2017, 8(11):2125-2132 doi: 10.1039/C7MD00415J
11. [11]
  WANG Wan-Wan, WANG Yuan, WU Wei-Na, et al. Chinese J. Inorg. Chem., 2018, 34:1511-1516 doi: 10.11862/CJIC.2018.196
12. [12]
  LIN Long, LI Xian-Hong, ZHANG Bo, et al. Chinese J. Inorg. Chem., 2017, 33:143-148 doi: 10.11862/CJIC.2016.283
13. [13]
  Sheldrick G M. SADABS, University of Göttingen, Germany, 1996.
14. [14]
  Sheldrick G M. SHELX-97, Program for the Solution and the Refinement of Crystal Structures, University of Göttingen, Germany, 1997.
15. [15]
  Addison A W, Rao T N. J. Chem. Soc. Dalton Trans., 1984:1349-1356
16. [16]
  MAO Pan-dong, ZHAO Xiao-Lei, SHAO Zhi-Peng, et al. Chinese J. Inorg. Chem., 2017, 33:890-896 doi: 10.11862/CJIC.2017.109
17. [17]
  Nakamoto K. Infrared and Raman Spectra of Inorganic and Coordination Compounds. 4th Ed. New York:Wiley, 1986:257
18. [18]
  Tu C, Shao Y, Gan N, et al. Inorg. Chem., 2004, 43:4761-4766 doi: 10.1021/ic049731g
1. [1]
  Kaimin WANG , Xiong GU , Na DENG , Hongmei YU , Yanqin YE , Yulu MA . Synthesis, structure, fluorescence properties, and Hirshfeld surface analysis of three Zn(Ⅱ)/Cu(Ⅱ) complexes based on 5-(dimethylamino) isophthalic acid. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1397-1408. doi: 10.11862/CJIC.20240009
2. [2]
  Lulu DONG , Jie LIU , Hua YANG , Yupei FU , Hongli LIU , Xiaoli CHEN , Huali CUI , Lin LIU , Jijiang WANG . Synthesis, crystal structure, and fluorescence properties of Cd-based complex with pcu topology. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 809-820. doi: 10.11862/CJIC.20240171
3. [3]
  Qingyan JIANG , Yanyong SHA , Chen CHEN , Xiaojuan CHEN , Wenlong LIU , Hao HUANG , Hongjiang LIU , Qi LIU . Constructing a one-dimensional Cu-coordination polymer-based cathode material for Li-ion batteries. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 657-668. doi: 10.11862/CJIC.20240004
4. [4]
  Xiaoling WANG , Hongwu ZHANG , Daofu LIU . Synthesis, structure, and magnetic property of a cobalt(Ⅱ) complex based on pyridyl-substituted imino nitroxide radical. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 407-412. doi: 10.11862/CJIC.20240214
5. [5]
  Yao HUANG , Yingshu WU , Zhichun BAO , Yue HUANG , Shangfeng TANG , Ruixue LIU , Yancheng LIU , Hong LIANG . Copper complexes of anthrahydrazone bearing pyridyl side chain: Synthesis, crystal structure, anticancer activity, and DNA binding. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 213-224. doi: 10.11862/CJIC.20240359
6. [6]
  Lu LIU , Huijie WANG , Haitong WANG , Ying LI . Crystal structure of a two-dimensional Cd(Ⅱ) complex and its fluorescence recognition of p-nitrophenol, tetracycline, 2, 6-dichloro-4-nitroaniline. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1180-1188. doi: 10.11862/CJIC.20230489
7. [7]
  Yinling HOU , Jia JI , Hong YU , Xiaoyun BIAN , Xiaofen GUAN , Jing QIU , Shuyi REN , Ming FANG . A rhombic Dy₄-based complex showing remarkable single-molecule magnet behavior. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 605-612. doi: 10.11862/CJIC.20240251
8. [8]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
9. [9]
  Jia JI , Zhaoyang GUO , Wenni LEI , Jiawei ZHENG , Haorong QIN , Jiahong YAN , Yinling HOU , Xiaoyan XIN , Wenmin WANG . Two dinuclear Gd(Ⅲ)-based complexes constructed by a multidentate diacylhydrazone ligand: Crystal structure, magnetocaloric effect, and biological activity. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 761-772. doi: 10.11862/CJIC.20240344
10. [10]
  Xiumei LI , Yanju HUANG , Bo LIU , Yaru PAN . Syntheses, crystal structures, and quantum chemistry calculation of two Ni(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2031-2039. doi: 10.11862/CJIC.20240109
11. [11]
  Xiumei LI , Linlin LI , Bo LIU , Yaru PAN . Syntheses, crystal structures, and characterizations of two cadmium(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 613-623. doi: 10.11862/CJIC.20240273
12. [12]
  Chao LIU , Jiang WU , Zhaolei JIN . Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1986-1994. doi: 10.11862/CJIC.20240153
13. [13]
  Xiaoxia WANG , Ya'nan GUO , Feng SU , Chun HAN , Long SUN . Synthesis, structure, and electrocatalytic oxygen reduction reaction properties of metal antimony-based chalcogenide clusters. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1201-1208. doi: 10.11862/CJIC.20230478
14. [14]
  Yan XU , Suzhi LI , Yan LI , Lushun FENG , Wentao SUN , Xinxing LI . Structure variation of cadmium naphthalene-diphosphonates with the changing rigidity of N-donor auxiliary ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 395-406. doi: 10.11862/CJIC.20240226
15. [15]
  Zhaodong WANG . In situ synthesis, crystal structure, and magnetic characterization of a trinuclear copper complex based on a multi-substituted imidazo[1,5-a]pyrazine scaffold. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 597-604. doi: 10.11862/CJIC.20240268
16. [16]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
17. [17]
  Xiaofen GUAN , Yating LIU , Jia LI , Yiwen HU , Haiyuan DING , Yuanjing SHI , Zhiqiang WANG , Wenmin WANG . Synthesis, crystal structure, and DNA-binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2486-2496. doi: 10.11862/CJIC.20240122
18. [18]
  Huan ZHANG , Jijiang WANG , Guang FAN , Long TANG , Erlin YUE , Chao BAI , Xiao WANG , Yuqi ZHANG . A highly stable cadmium(Ⅱ) metal-organic framework for detecting tetracycline and p-nitrophenol. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 646-654. doi: 10.11862/CJIC.20230291
19. [19]
  Ruikui YAN , Xiaoli CHEN , Miao CAI , Jing REN , Huali CUI , Hua YANG , Jijiang WANG . Design, synthesis, and fluorescence sensing performance of highly sensitive and multi-response lanthanide metal-organic frameworks. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 834-848. doi: 10.11862/CJIC.20230301
20. [20]
  Shuyan ZHAO . Field-induced Co^Ⅱ single-ion magnet with pentagonal bipyramidal configuration. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1583-1591. doi: 10.11862/CJIC.20240231

Get Citation

PDF

XML

Metrics

PDF Downloads(9)
Abstract views(725)
HTML views(35)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142