Citation: YAN Xiao-Lin, GUO Hai-Fu, YAN Peng, ZHU Jia-Min, WANG Ying, TAN Jia-Mei, DING Min, ZHENG Yong-Rui. Synthesis, Characterization and Drug Delivery of a Water-Stable and Methyl-Functionalized 2D Zinc(Ⅱ) Metal-Organic Framework[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(7): 1267-1274. doi: 10.11862/CJIC.2019.137 shu

Synthesis, Characterization and Drug Delivery of a Water-Stable and Methyl-Functionalized 2D Zinc(Ⅱ) Metal-Organic Framework

1.
College of Science, Inner Mongolia Agricultural University, Huhhot 010018, China
2.
School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing, Guangdong 526061, China

Corresponding author: GUO Hai-Fu, guohaifu@sina.com
Received Date: 18 December 2018
Revised Date: 3 April 2019

Figures(6)

By using a methyl-functionalized N-donor ligand, a water-stable zinc-based MOF {[Zn(BDC)(dmbpy)]·4H₂O}_n (1) (BDC=isophthalate, dmbpy=3, 3'-dimethyl-4, 4'-bipyridine) was synthesized and structurally character-ized. TGA and PXRD results show high thermal and water stability for 1.1 exhibits a 2D (4, 4) net with channels of 0.92 nm×0.83 nm and 0.82 nm×0.39 nm along the b axis, respectively. De-solvated 1 adsorbs around 14.2%(w/w) 5-fluorouracil (5-FU) and the cumulative release value of 5-FU after 70 h was about 94.5% and 99% in PBS (pH=7.4 and pH=6.0) at 37℃, respectively. The in vivo zebrafish toxicity tests and in vitro MTT assays of 1 at different concentrations results reveal that 1 is nontoxic (cell viability>80%) up to concentrations of 500 μg·mL^-1.
- zinc-organic framework,
- water-stable,
- synthesis,
- characterization,
- drug delivery
1. [1]
  Banerjee D, Elsaidi S K, Thallapally P K. J. Mater. Chem. A, 2017, 5:16611-16615 doi: 10.1039/C7TA02746J
2. [2]
  Lee S J, Kim S, Kim E J, et al. Chem. Eng. J., 2018, 335:345-351 doi: 10.1016/j.cej.2017.10.155
3. [3]
  Medishetty R, Zareba J K, Mayer D, et al. Chem. Soc. Rev., 2017, 46:4976-5004 doi: 10.1039/C7CS00162B
4. [4]
  (a) Chen L F, Xu Q. Science, 2017, 358: 304-305
  (b)LIU Yuan-Yuan(刘媛媛)), LI Xin-Shu(李欣书), ZHANG Hui-Min(张慧敏), et al. Chinese J. Inorg. Chem.(无机化学学报), 2018, 35(12): 2280-2290
5. [5]
  Espallargas G M, Coronado E. Chem. Soc. Rev., 2018, 47:533-557 doi: 10.1039/C7CS00653E
6. [6]
  (a) Zheng K, Liu Z Q, Chen F, et al. Sens. Actuators B: Chem., 2018, 257: 705-713
  (b)LU Yan-Lei(卢延磊), ZHU Ning(朱宁), ZHAO Yu-Meng (赵宇萌), et al. Chinese J. Inorg. Chem.(无机化学学报), 2019, 35(4): 720-728
7. [7]
  Ma D Y, Xie J, Zhu Z, et al. Inorg. Chem. Commun., 2017, 86:128-132 doi: 10.1016/j.inoche.2017.10.007
8. [8]
  Zhang X J, Wang W J, Hu Z J, et al. Coord. Chem. Rev., 2015, 284:206-235 doi: 10.1016/j.ccr.2014.10.006
9. [9]
  Yu Y J, Yu C, Niu Y Z, et al. Biosens. Bioelectron., 2018, 101:297-303 doi: 10.1016/j.bios.2017.10.006
10. [10]
  Assen A H, Yassine O, Shekhah O. ACS Sens., 2017, 2:1294-1301 doi: 10.1021/acssensors.7b00304
11. [11]
  Ma D Y, Li Y W, Li Z. Chem. Commun., 2011, 47:7377-7379 doi: 10.1039/c1cc11752a
12. [12]
  Mitra S, Sasmal H S, Kundu T, et al. J. Am. Chem. Soc., 2017, 139:4513-4520 doi: 10.1021/jacs.7b00925
13. [13]
  Keskin S, Kizilel S. Ind. Eng. Chem. Res., 2011, 4:1799-1812
14. [14]
  Horcajada P, Serre C, Vallet-Regi M, et al. Angew. Chem. Int. Ed., 2006, 118:6120-6124 doi: 10.1002/(ISSN)1521-3757
15. [15]
  APEX Ⅱ Software, Vers. 6.3.1, Bruker AXS Inc, Madison, Wisconsin, USA, 2004.
16. [16]
  Sheldrick G M. Acta Crystallogr. Sect. A:Found. Crystallogr., 2008, A64:112-122
17. [17]
  Spek A L. PLATON, A Multipurpose Crystallographic Tool, Utrecht University, The Netherlands, 2005.
18. [18]
  Wang J, Ma D Y, Liao W L, et al. CrystEngComm, 2017, 19:5244-5250 doi: 10.1039/C7CE01238A
19. [19]
  Chalati T, Horcajada P, Couvreur P, et al. Nanomedicine, 2011, 6:1683-1695 doi: 10.2217/nnm.11.69
20. [20]
  Zhao X S, Wang S T, Wu Y, et al. Aquat. Toxicol., 2013, 136-137:49-59 doi: 10.1016/j.aquatox.2013.03.019
21. [21]
  Chen T H, Lin C C, Meng P J. J. Hazard. Mater., 2014, 277:134-140 doi: 10.1016/j.jhazmat.2013.12.030
22. [22]
  Ma D Y, Lu K, Qin L, et al. Inorg. Chim. Acta, 2013, 396:84-91 doi: 10.1016/j.ica.2012.10.006
23. [23]
  Sun C Y, Qin C, Wang C G, et al. Adv. Mater., 2011, 23:5629-5632 doi: 10.1002/adma.v23.47
24. [24]
  Li Q L, Wang J P, Liu W C, et al. Inorg. Chem. Commun., 2015, 55:8-10 doi: 10.1016/j.inoche.2015.02.023
25. [25]
  Bag P P, Wang D, Chen Z, et al. Chem. Commun., 2016, 52:3669-3672 doi: 10.1039/C5CC09925K
26. [26]
  Liu J Q, Li X F, Gu C Y, et al. Dalton Trans., 2015, 44:19370-19382 doi: 10.1039/C5DT02171E
27. [27]
  Liu J Q, Wu J, Jia Z B, et al. Dalton Trans., 2014, 43:17265-17273 doi: 10.1039/C4DT01890G
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2. [2]
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沈阳化工大学材料科学与工程学院沈阳 110142