Citation: ZHANG Yan, MENG Xiang-Gao, CAI Ping, CHENG Gong-Zhen, JIA Shi-Fang. Synthesis, Crystal Structure, Anticancer Activity and Interaction with Bovine Serum Albumin of Copper(Ⅱ) Complex[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1864-1874. doi: 10.11862/CJIC.2018.234 shu

Synthesis, Crystal Structure, Anticancer Activity and Interaction with Bovine Serum Albumin of Copper(Ⅱ) Complex

1.
School of Chemical and Biological Engineering, Taiyuan Science and Technology University, Taiyuan 030021, China
2.
College of Chemistry, Central China Normal University, Wuhan 430079, China
3.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

Corresponding author: ZHANG Yan, yanzhang872010@163.com JIA Shi-Fang, jiashifang@126.com
Received Date: 27 February 2018
Revised Date: 20 July 2018

Figures(9)

A four-coordinated Cu(Ⅱ) complex with Schiff base ligand was synthesized and characterized by the elemental analysis and infrared spectroscopy, and the crystal structure was determined by X-ray diffraction. The crystal of complex belongs to monoclinic system. In vitro antitumor activities of Cu(Ⅱ) complex were evaluated by the 3-(4, 5-dimethylthiazoly-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT) assay against four human cancer cell lines (Hela, SGC-7901, HepG2, MCF-7). Cu(Ⅱ) complex exhibited stronger antitumor activity than carboplatin. The interaction of Cu(Ⅱ) complex with bovine serum albumin (BSA) was studied by spectroscopic method. The analysis of fluorescence data indicates the presence of static quenching mechanism in the binding process. Various binding parameters including binding constants, binding sites, binding distance and thermodynamic parameters ΔH, ΔS and ΔG have been evaluated.
- Cu(Ⅱ)complex,
- crystal structure,
- anticancer activity,
- bovine serum albumin,
- fluorescence spectra
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