Citation: CHAI Jie, YANG Bin-Sheng, LIU Bin. Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1783-1791. doi: 10.11862/CJIC.2018.217 shu

Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives

Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006, China

Corresponding author: YANG Bin-Sheng, yangbs@sxu.edu.cn LIU Bin, liubin@sxu.edu.cn
Received Date: 7 April 2018
Revised Date: 21 June 2018

Figures(8)

Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction, ESI-MS, analytical element, conductivity and IR analysis. The effect of substituent groups on its redox property and hydroxyl radical (·OH) generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction. As a result, three complexes generate less ·OH than Cr(pic)₃. Besides, acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)₃ in reducing fasten blood glucose (FBG) and low density lipoprotein by low dose.
- chromium picolinate,
- redox property,
- safety,
- antihyperglycemic effects
1. [1]
  Levina A, Lay P A. Dalton Trans., 2011, 40(44):11675-11686 doi: 10.1039/c1dt10380f
2. [2]
  FENG Yong-Lan, YU Jiang-Xi, JIANG Wu-Jiu, et al. Chinese J. Inorg. Chem., 2018, 34(1):99-104
3. [3]
  GE Chao, WANG Hong-Yan, DONG Yi-Li, et al. Chinese J. Inorg. Chem., 2018, 34(6):1079-1085
4. [4]
  LI Jing, WU Chun-Yang, ZHANG Ying, et al. Chinese J. Inorg. Chem., 2018, 34(1): 135-141
5. [5]
  BAI Feng-Ying, WANG Xue-Min, QU Chang-Qing, et al. Chinese J. Inorg. Chem., 2018, 34(4):639-646
6. [6]
  Schwarz K, Mertz W. Arch. Biochem. Biophys., 1959, 85(1): 292-295 doi: 10.1016/0003-9861(59)90479-5
7. [7]
  SUN Zhan-Guo, LIU Bin, YANG Bin-Sheng. Chinese Journal of Spectroscopy Laboratory, 2009, 26(3):564-566 doi: 10.3969/j.issn.1004-8138.2009.03.027
8. [8]
  DUAN Wen-Sheng, LIU Bin, YANG Bin-Sheng. Chinese Journal of Spectroscopy Laboratory, 2009, 26(2):376-378 doi: 10.3969/j.issn.1004-8138.2009.02.055
9. [9]
  LIU Bin, SUN Zhan-Guo, YANG Bin-Sheng. Acta Chim. Sinica, 2008, 66(21):2353-2359 doi: 10.3321/j.issn:0567-7351.2008.21.007
10. [10]
  NAN Jun-Xia, LIU Bin, YANG Bin-Sheng. Acta Chim. Sinica, 2011, 69(6):640-646
11. [11]
  DUAN Wen-Sheng, LIU Bin, SUN Zhan-Guo, et al. Acta Chim. Sinica, 2011, 69(15): 1789-1794
12. [12]
  Vincent J B. Acc. Chem. Res., 2000, 33(7):503-510 doi: 10.1021/ar990073r
13. [13]
  Vaidyanathan V G, Weyhermuller T, Nair B U, et al. J. Inorg. Biochem., 2005, 99(11):2248-2255 doi: 10.1016/j.jinorgbio.2005.08.007
14. [14]
  Vijayalakshmi R, Kanthimathi M, Subramanian V, et al. Biochem. Biophys. Res. Commun., 2000, 271(3):731-734 doi: 10.1006/bbrc.2000.2707
15. [15]
  Parand A, Royer A C, Cantrell T L, et al. Inorg. Chim. Acta, 1998, 268(2):211-219 doi: 10.1016/S0020-1693(97)05739-3
16. [16]
  Jana M, Rajaram A, Rajaram R. Toxicol. Appl. Pharmacol., 2009, 237(3):331-344 doi: 10.1016/j.taap.2009.04.006
17. [17]
  Sugden K D, Geer R D, Rogers S J. Biochemistry, 1992, 31 (46):11626-11631 doi: 10.1021/bi00161a049
18. [18]
  Speetjens J K, Collins R A, Vincent J B, et al. Chem. Res. Toxicol., 1999, 12(6):483-487 doi: 10.1021/tx9900167
19. [19]
  Biswas A, Divya S, Mandal A B, et al. Anim. Reprod. Sci., 2014, 151(3/4):237-243
20. [20]
  Ganguly R, Sahu S, Ohanyan V, et al. Sci. Rep., 2017, 7: 45279 doi: 10.1038/srep45279
21. [21]
  Ganguly R, Wen A M, Myer A B, et al. Nanoscale, 2016, 8 (12):6542-6554 doi: 10.1039/C6NR00398B
22. [22]
  Ganguly R, Sahu S, Chavez R J, et al. Am. J. Physiol., 2015, 308(2):C111-C122
23. [23]
  Vincent J B. Biol. Trace Elem. Res., 2015, 166(1):7-12 doi: 10.1007/s12011-015-0231-9
24. [24]
  Sheldrick G M. SHELXL-97, Program for the Refinement of Crystal Structures, University of Göttingen, Germany, 1997.
25. [25]
  Nair V, Turner G A. Lipids, 1989, 18(10):804-805
26. [26]
  Steams D M, Armsbong W H. Inorg. Chem., 1992, 31(25): 5178-5184 doi: 10.1021/ic00051a007
27. [27]
  Chai J, Liu Y F, Dong J L, et al. Inorg. Chim. Acta, 2017, 466:151-159 doi: 10.1016/j.ica.2017.05.041
28. [28]
  Weeks C L, Levina A, Dillon C T, et al. Inorg. Chem., 2004, 43(24):7844-7856 doi: 10.1021/ic049008q
29. [29]
  Parajón-Costa B S, Wagner C C, Baran E J. Z. Anorg. Allg. Chem., 2003, 629(6):1085-1090 doi: 10.1002/zaac.200300050
30. [30]
  Cabrera P J, Yang X, Suttil J A, et al. Inorg. Chem., 2015, 54(21):10214-10223 doi: 10.1021/acs.inorgchem.5b01328
31. [31]
  Hansch C, Leo A, Taft R W. Chem. Rev., 1991, 91(2):165- 195 doi: 10.1021/cr00002a004
32. [32]
  Liu B, Liu Y F, Chai J, et al. J. Inorg. Biochem., 2016, 164 (1):110-118
33. [33]
  Levina A, Pham T H, Lay P A. Angew. Chem. Int. Ed., 2016, 55(28):8104-8107 doi: 10.1002/anie.201602996
34. [34]
  Kasetsuwan N, Wu F M, Hsieh F, et al. Arch. Ophthalmol., 1999, 117(5):649-652 doi: 10.1001/archopht.117.5.649
35. [35]
  Bennett R, Adams B, French A, et al. Biol. Trace Elem. Res., 2006, 113(1):53-66 doi: 10.1385/BTER:113:1
36. [36]
  Jain S K, Rains J L, Croad J L. Antioxid. Redox Signal., 2007, 9(10):1581-1590 doi: 10.1089/ars.2007.1577
37. [37]
  Vincent J B. Polyhedron, 2001, 20(68):1-26
1. [1]
  Zilin Hu , Yaoshen Niu , Xiaohui Rong , Yongsheng Hu . Suppression of Voltage Decay through Ni³⁺ Barrier in Anionic-Redox Active Cathode for Na-Ion Batteries. Acta Physico-Chimica Sinica, 2024, 40(6): 2306005-0. doi: 10.3866/PKU.WHXB202306005
2. [2]
  Lifang HE , Wenjie TANG , Yaoze LUO , Mingsheng LIANG , Jianxin TANG , Yuxuan WU , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two dialkyltin complexes constructed based on 2, 2′-bipyridin-6, 6′-dicarboxylic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1601-1609. doi: 10.11862/CJIC.20250012
3. [3]
  Jingkun Yu , Xue Yong , Ang Cao , Siyu Lu . Bi-Layer Single Atom Catalysts Boosted Nitrate-to-Ammonia Electroreduction with High Activity and Selectivity. Acta Physico-Chimica Sinica, 2024, 40(6): 2307015-0. doi: 10.3866/PKU.WHXB202307015
4. [4]
  Jianan Hong , Chenyu Xu , Yan Liu , Changqi Li , Menglin Wang , Yanwei Zhang . Decoding the interfacial competition between hydrogen evolution and CO₂ reduction via edge-active-site modulation in photothermal catalysis. Acta Physico-Chimica Sinica, 2025, 41(9): 100099-0. doi: 10.1016/j.actphy.2025.100099
5. [5]
  Rong Tian , Yadi Yang , Naihao Lu . Comprehensive Experimental Design of Undergraduate Students Based on Interdisciplinarity: Study on the Effect of Quercetin on Chlorination Activity of Myeloperoxidase. University Chemistry, 2024, 39(8): 247-254. doi: 10.3866/PKU.DXHX202312064
6. [6]
  Hui-Ying Chen , Hao-Lin Zhu , Pei-Qin Liao , Xiao-Ming Chen . Integration of Ru(Ⅱ)-Bipyridyl and Zinc(Ⅱ)-Porphyrin Moieties in a Metal-Organic Framework for Efficient Overall CO₂ Photoreduction. Acta Physico-Chimica Sinica, 2024, 40(4): 2306046-0. doi: 10.3866/PKU.WHXB202306046
7. [7]
  Xiaotong LU , Pan ZHANG , Zijie ZHAO , Lei HUANG , Hongwei ZUO , Lili LIANG . Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1523-1532. doi: 10.11862/CJIC.20250073
8. [8]
  Xichen YAO , Shuxian WANG , Yun WANG , Cheng WANG , Chuang ZHANG . Oxygen reduction performance of self?supported Fe/N/C three-dimensional aerogel catalyst layers. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1387-1396. doi: 10.11862/CJIC.20240384
9. [9]
  Jinyi Sun , Lin Ma , Yanjie Xi , Jing Wang . Preparation and Electrocatalytic Nitrogen Reduction Performance Study of Vanadium Nitride@Nitrogen-Doped Carbon Composite Nanomaterials: A Recommended Comprehensive Chemistry Experiment. University Chemistry, 2024, 39(4): 184-191. doi: 10.3866/PKU.DXHX202310094
10. [10]
  Yanan Liu , Yufei He , Dianqing Li . Preparation of Highly Dispersed LDHs-based Catalysts and Testing of Nitro Compound Reduction Performance: A Comprehensive Chemical Experiment for Research Transformation. University Chemistry, 2024, 39(8): 306-313. doi: 10.3866/PKU.DXHX202401081
11. [11]
  Zelong LIANG , Shijia QIN , Pengfei GUO , Hang XU , Bin ZHAO . Synthesis and electrocatalytic CO₂ reduction performance of metal-organic framework catalysts loaded with silver particles. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 165-173. doi: 10.11862/CJIC.20240409
12. [12]
  Jianyu Qin , Yuejiao An , Yanfeng Zhang . In Situ Assembled ZnWO₄/g-C₃N₄ S-Scheme Heterojunction with Nitrogen Defect for CO₂ Photoreduction. Acta Physico-Chimica Sinica, 2024, 40(12): 2408002-0. doi: 10.3866/PKU.WHXB202408002
13. [13]
  Haotong Ma , Mingyu Heng , Yang Xu , Wei Bi , Yingchun Miao , Shuning Xiao . Synergistic carbon doping and Cu loading on boron nitride via microwave synthesis for enhanced atmospheric CO₂ photoreduction. Acta Physico-Chimica Sinica, 2025, 41(11): 100132-0. doi: 10.1016/j.actphy.2025.100132
14. [14]
  Yunting Shang , Yue Dai , Jianxin Zhang , Nan Zhu , Yan Su . Something about RGO (Reduced Graphene Oxide). University Chemistry, 2024, 39(9): 273-278. doi: 10.3866/PKU.DXHX202306050
15. [15]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
16. [16]
  Hao XU , Ruopeng LI , Peixia YANG , Anmin LIU , Jie BAI . Regulation mechanism of halogen axial coordination atoms on the oxygen reduction activity of Fe-N₄ site: A density functional theory study. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 695-701. doi: 10.11862/CJIC.20240302
17. [17]
  Shiqian WEI , Xinyu TIAN , Hong LIU , Maoxia CHEN , Fan TANG , Qiang FAN , Weifeng FAN , Yu HU . Oxygen reduction reaction/oxygen evolution reaction catalytic performances of different active sites on nitrogen-doped graphene loaded with iron single atoms. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1776-1788. doi: 10.11862/CJIC.20250102
18. [18]
  Yi DING , Peiyu LIAO , Jianhua JIA , Mingliang TONG . Structure and photoluminescence modulation of silver(Ⅰ)-tetra(pyridin-4-yl)ethene metal-organic frameworks by substituted benzoates. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 141-148. doi: 10.11862/CJIC.20240393
19. [19]
  Jing Zhang , Su Zhang , Qiqi Li , Linken Ji , Yutong Li , Yukang Ren , Xiaobei Zang , Ning Cao , Han Hu , Peng Liang , Zhuangjun Fan . Integrating high surface area and electric conductivity in activated carbon by in situ formation of the less-defective carbon network during selective chemical etching. Acta Physico-Chimica Sinica, 2025, 41(10): 100114-0. doi: 10.1016/j.actphy.2025.100114
20. [20]
  Wentao Xu , Xuyan Mo , Yang Zhou , Zuxian Weng , Kunling Mo , Yanhua Wu , Xinlin Jiang , Dan Li , Tangqi Lan , Huan Wen , Fuqin Zheng , Youjun Fan , Wei Chen . Bimetal Leaching Induced Reconstruction of Water Oxidation Electrocatalyst for Enhanced Activity and Stability. Acta Physico-Chimica Sinica, 2024, 40(8): 2308003-0. doi: 10.3866/PKU.WHXB202308003

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(1691)
HTML views(325)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142