Citation: WU Hao, ZHAO Xiao-Lei, ZHONG Run-Bin, DAI Geng-Geng, WU Wei-Na, WANG Yuan. Synthesis, Crystal Structure and DNA Interaction of a Cu(Ⅱ) Complex with Bis-hydrazone Ligand Bearing Pyrazine Unit[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1917-1922. doi: 10.11862/CJIC.2018.215 shu

Synthesis, Crystal Structure and DNA Interaction of a Cu(Ⅱ) Complex with Bis-hydrazone Ligand Bearing Pyrazine Unit

College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo, Henan 454000, China

Corresponding author: ZHAO Xiao-Lei, zhaoxiaolei@hpu.edu.cn WU Wei-Na, wuwn08@hpu.edu.cn
Received Date: 25 May 2018
Revised Date: 12 June 2018

Figures(4)

A complex, namely[Cu₄(L)₂(CH₃O)₂(CH₃OH)₄(SO₄)₂]SO₄·6CH₃OH (1) (L=N, N'-bis-(1-(3-ethyl-pyrazin-2-yl)-ethylidene)-hydrazine) has been synthesized and characterized by single-crystal X-ray diffraction, elemental analysis and IR spectroscopy. X-ray diffraction analysis results show that in complex 1, each Cu(Ⅱ) center with a distorted octahedron geometry is coordinated by two N atoms from one pyrazin-2-yl-ethylideneamine subunit, and four O atoms involving one O atom from one neutral methanol, one μ₂-bridged O atom from one methoxy anion, one μ₂-bridged O and one monodentate O atoms from two independent sulfate anions, thus forming an ideal planar fourmembered Cu₄ core. In addition, the fluorescence spectra indicate that the interaction of complex 1 with DNA is stronger than that of the ligand L.
- bis-hydrazone,
- crystal structure,
- Cu(Ⅱ)complex,
- DNA interaction,
- pyrazine
1. [1]
  Patil R H, Khan F A K, Jadhav K, et al. Arch. Pharm., 2018, 351:3-4
2. [2]
  Casanova I, Duran M L, Viqueira J, et al. Dalton Trans., 2018, 47:4325-4340 doi: 10.1039/C8DT00532J
3. [3]
  Palanimurugan A, Kulandaisamy A. J. Organomet. Chem., 2018, 861:263-274 doi: 10.1016/j.jorganchem.2018.02.051
4. [4]
  Salar U, Khan K M, Chigurupati S, et al. Sci. Rep., 2017, 7:16980 doi: 10.1038/s41598-017-17261-w
5. [5]
  Liang S, Tran H L, Were L. Food Chem., 2018, 252:318-326 doi: 10.1016/j.foodchem.2018.01.118
6. [6]
  Erxleben A. Coord. Chem. Rev., 2018, 360:92-121 doi: 10.1016/j.ccr.2018.01.008
7. [7]
  Dubey P, Gupta S, Singh A K, et al. Dalton Trans., 2018, 47:3764-3774 doi: 10.1039/C7DT04326K
8. [8]
  Kalaiarasi G, Rajkumar S R J, Dharani S, et al. J. Photochem. Photobiol. B, 2018, 180:77-88 doi: 10.1016/j.jphotobiol.2018.01.017
9. [9]
  WU Hao, CHEN Ze-Hua, YU Ya-Ping, et al. Chinese J. Inorg. Chem., 2017, 33:699-704 doi: 10.11862/CJIC.2017.051
10. [10]
  Qi J, Deng J, Qian K, et al. Eur. J. Med. Chem., 2017, 134:34-42 doi: 10.1016/j.ejmech.2017.04.009
11. [11]
  Rogolino D, Cavazzoni A, Gatti A, et al. Eur. J. Med. Chem., 2017, 128:140-153 doi: 10.1016/j.ejmech.2017.01.031
12. [12]
  Geitner R, Gotz S, Stach R, et al. J. Phys. Chem. A, 2018, 122:2677-2687 doi: 10.1021/acs.jpca.7b12648
13. [13]
  Venkatachalam T K, Bernhardt P V, Noble C J, et al. J. Inorg. Biochem., 2016, 162:295-308 doi: 10.1016/j.jinorgbio.2016.04.006
14. [14]
  MAO Pan-Dong, HAN Xue-Feng, WU Wei-Na, et al. Chinese J. Inorg. Chem., 2016, 32:161-166
15. [15]
  Li M X, Zhang L Z, Yang M, et al. Bioorg. Med. Chem. Lett., 2012, 22:2418-2433 doi: 10.1016/j.bmcl.2012.02.024
16. [16]
  Li M X, Zhang L Z, Zhang D, et al. Eur. J. Med. Chem., 2011, 46:4383-4390 doi: 10.1016/j.ejmech.2011.07.009
17. [17]
  MAO Pan-Dong, ZHAO Xiao-Lei, SHAO Zhi-Peng, et al. Chinese J. Inorg. Chem., 2017, 33:890-896 doi: 10.11862/CJIC.2017.109
18. [18]
  Sheldrick G M. SADABS, University of Göttingen, Germany, 1996.
19. [19]
  Sheldrick G M. SHELX-97, Program for the Solution and the Refinement of Crystal Structures, University of Göttingen, Germany, 1997.
20. [20]
  Nakamoto K. Infrared and Raman Spectra of Inorganic and Coordination Compounds. 4th Ed. New York:Wiley, 1986:257
1. [1]
  Yao HUANG , Yingshu WU , Zhichun BAO , Yue HUANG , Shangfeng TANG , Ruixue LIU , Yancheng LIU , Hong LIANG . Copper complexes of anthrahydrazone bearing pyridyl side chain: Synthesis, crystal structure, anticancer activity, and DNA binding. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 213-224. doi: 10.11862/CJIC.20240359
2. [2]
  Lu LIU , Huijie WANG , Haitong WANG , Ying LI . Crystal structure of a two-dimensional Cd(Ⅱ) complex and its fluorescence recognition of p-nitrophenol, tetracycline, 2, 6-dichloro-4-nitroaniline. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1180-1188. doi: 10.11862/CJIC.20230489
3. [3]
  Lulu DONG , Jie LIU , Hua YANG , Yupei FU , Hongli LIU , Xiaoli CHEN , Huali CUI , Lin LIU , Jijiang WANG . Synthesis, crystal structure, and fluorescence properties of Cd-based complex with pcu topology. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 809-820. doi: 10.11862/CJIC.20240171
4. [4]
  Xiaoling WANG , Hongwu ZHANG , Daofu LIU . Synthesis, structure, and magnetic property of a cobalt(Ⅱ) complex based on pyridyl-substituted imino nitroxide radical. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 407-412. doi: 10.11862/CJIC.20240214
5. [5]
  Kaimin WANG , Xiong GU , Na DENG , Hongmei YU , Yanqin YE , Yulu MA . Synthesis, structure, fluorescence properties, and Hirshfeld surface analysis of three Zn(Ⅱ)/Cu(Ⅱ) complexes based on 5-(dimethylamino) isophthalic acid. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1397-1408. doi: 10.11862/CJIC.20240009
6. [6]
  Jia JI , Zhaoyang GUO , Wenni LEI , Jiawei ZHENG , Haorong QIN , Jiahong YAN , Yinling HOU , Xiaoyan XIN , Wenmin WANG . Two dinuclear Gd(Ⅲ)-based complexes constructed by a multidentate diacylhydrazone ligand: Crystal structure, magnetocaloric effect, and biological activity. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 761-772. doi: 10.11862/CJIC.20240344
7. [7]
  Yinling HOU , Jia JI , Hong YU , Xiaoyun BIAN , Xiaofen GUAN , Jing QIU , Shuyi REN , Ming FANG . A rhombic Dy₄-based complex showing remarkable single-molecule magnet behavior. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 605-612. doi: 10.11862/CJIC.20240251
8. [8]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
9. [9]
  Xiumei LI , Yanju HUANG , Bo LIU , Yaru PAN . Syntheses, crystal structures, and quantum chemistry calculation of two Ni(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2031-2039. doi: 10.11862/CJIC.20240109
10. [10]
  Xiumei LI , Linlin LI , Bo LIU , Yaru PAN . Syntheses, crystal structures, and characterizations of two cadmium(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 613-623. doi: 10.11862/CJIC.20240273
11. [11]
  Chao LIU , Jiang WU , Zhaolei JIN . Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1986-1994. doi: 10.11862/CJIC.20240153
12. [12]
  Xiaoxia WANG , Ya'nan GUO , Feng SU , Chun HAN , Long SUN . Synthesis, structure, and electrocatalytic oxygen reduction reaction properties of metal antimony-based chalcogenide clusters. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1201-1208. doi: 10.11862/CJIC.20230478
13. [13]
  Yan XU , Suzhi LI , Yan LI , Lushun FENG , Wentao SUN , Xinxing LI . Structure variation of cadmium naphthalene-diphosphonates with the changing rigidity of N-donor auxiliary ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 395-406. doi: 10.11862/CJIC.20240226
14. [14]
  Zhaodong WANG . In situ synthesis, crystal structure, and magnetic characterization of a trinuclear copper complex based on a multi-substituted imidazo[1,5-a]pyrazine scaffold. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 597-604. doi: 10.11862/CJIC.20240268
15. [15]
  Huan ZHANG , Jijiang WANG , Guang FAN , Long TANG , Erlin YUE , Chao BAI , Xiao WANG , Yuqi ZHANG . A highly stable cadmium(Ⅱ) metal-organic framework for detecting tetracycline and p-nitrophenol. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 646-654. doi: 10.11862/CJIC.20230291
16. [16]
  Ruikui YAN , Xiaoli CHEN , Miao CAI , Jing REN , Huali CUI , Hua YANG , Jijiang WANG . Design, synthesis, and fluorescence sensing performance of highly sensitive and multi-response lanthanide metal-organic frameworks. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 834-848. doi: 10.11862/CJIC.20230301
17. [17]
  Shuyan ZHAO . Field-induced Co^Ⅱ single-ion magnet with pentagonal bipyramidal configuration. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1583-1591. doi: 10.11862/CJIC.20240231
18. [18]
  Xiaofen GUAN , Yating LIU , Jia LI , Yiwen HU , Haiyuan DING , Yuanjing SHI , Zhiqiang WANG , Wenmin WANG . Synthesis, crystal structure, and DNA-binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2486-2496. doi: 10.11862/CJIC.20240122
19. [19]
  Jingwen Zhao , Jianpu Tang , Zhen Cui , Limin Liu , Dayong Yang , Chi Yao . A DNA micro-complex containing polyaptamer for exosome separation and wound healing. Chinese Chemical Letters, 2024, 35(9): 109303-. doi: 10.1016/j.cclet.2023.109303
20. [20]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(345)
HTML views(59)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142