Citation: WANG Yan-Hua, HAO Hang, WU Jian-Xiong, YAO Yuan, QIN Na, HE Wen-Cong. Enhanced Antitumor Effect and Drug Delivery from Se Doped Hydroxyapatite Microspheres[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(8): 1517-1530. doi: 10.11862/CJIC.2018.199 shu

Enhanced Antitumor Effect and Drug Delivery from Se Doped Hydroxyapatite Microspheres

WANG Yan-Hua ^1,, ,
HAO Hang ² ,
WU Jian-Xiong ¹ ,
YAO Yuan ¹ ,
QIN Na ¹ ,
HE Wen-Cong ³

1.
Medical College of China Three Gorges University, Yichang, Hubei 443002, China
2.
Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China
3.
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443002, China

Corresponding author: WANG Yan-Hua, wangyanhua@ctgu.edu.cn
Received Date: 11 February 2018
Revised Date: 7 June 2018

Figures(8)

Selenium doped hydroxyapatite microspheres (HASe) were prepared by using self-sacrificing CaCO₃ as template via hydrothermal route, and their physicochemical properties were characterized by SEM, TEM, DLS, XRD, FTIR and TGA. The curcumin was employed as the model drug, and its delivery behavior from HASe microspheres was evaluated with the loading efficacy and controlled-release efficiency. As a result, it was observed that the synthetic HASe products are spherical with an average diameter of about 1.0 μm. The surface of the microspheres is constructed by subtle units of hydroxyapatite nanorods which are 150 nm in length and 20 nm in width. HASe microspheres exhibit a high drug loading efficacy and slowly sustainable release behavior for curcumin. The loading amount of HASe10 was (88.72±0.01) mg·g^-1, and less than 1.5 mg of curcumin was released from it during 0~159 h. There is no burst release but slow sustainable release manner in it. Moreover, the toxicity of HASe microspheres was investigated by blood assay and cell experiment. Compared with selenium-free HA microspheres, HASe microspheres show lower blood toxicity to healthy man, and less damage to normal cells, but stronger inhibition on the growth of the osteosarcoma cells.
- hydroxyapatite,
- selenium,
- hollow microspheres,
- drug delivery system,
- curcumin
1. [1]
  Maia A L, Cavalcante C H, Souza M G, et al. Nucl. Med. Commun., 2016, 37:775-782 doi: 10.1097/MNM.0000000000000510
2. [2]
  ZU Qing-Xia, LI Ya-Ming, HAN Dan. Journal of Functional Materials, 2018, 49(2):2130-2135
3. [3]
  Raina D B, Isaksson H, Hettwer W, et al. Sci. Rep., 2016, 6:26033-26045 doi: 10.1038/srep26033
4. [4]
  Hayashi M, Aoshi T, Kogai Y, et al. Vaccine, 2016, 34:306-312 doi: 10.1016/j.vaccine.2015.11.059
5. [5]
  Wang X P, Li X, Ito A, et al. Chem. Commun., 2016, 52:7078-7081 doi: 10.1039/C6CC02848A
6. [6]
  Bertran O, Revilla-Lopez G, Casanovas J, et al. Chemistry, 2016, 22:6631-6636 doi: 10.1002/chem.201600703
7. [7]
  Ilie A, Ghitulica C, Andronescu E, et al. Int. J. Pharm., 2016, 510:501-507 doi: 10.1016/j.ijpharm.2016.01.025
8. [8]
  Jafari S, Maleki-Dizaji N, Barar J, et al. Eur. J. Pharm. Sci., 2016, 91:225-235 doi: 10.1016/j.ejps.2016.05.014
9. [9]
  Chen X, Yang B, Qi C, et al. Dalton Trans., 2016, 45:1648-1656 doi: 10.1039/C5DT03357H
10. [10]
  Kamitakahara M, Ohtoshi N, Kawashita M, et al. J. Mater. Sci.:Mater. Med., 2016, 27:93-99 doi: 10.1007/s10856-016-5704-7
11. [11]
  Li D, Huang X, Wu Y, et al. Biomater. Sci., 2016, 4:272-280 doi: 10.1039/C5BM00228A
12. [12]
  Benedetti M, De Castro F, Romano A, et al. J. Inorg. Biochem., 2016, 157:73-79 doi: 10.1016/j.jinorgbio.2016.01.019
13. [13]
  Wang Y, Hao H, Zhang S. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 61:545-552 doi: 10.1016/j.msec.2015.12.060
14. [14]
  Lai W, Chen C, Ren X, et al. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 62:166-172 doi: 10.1016/j.msec.2016.01.055
15. [15]
  Yang P P, Quan Z W, Li C X, et al. Biomaterials, 2008, 29:4341-4347 doi: 10.1016/j.biomaterials.2008.07.042
16. [16]
  Xie G P, Sun J A, Zhong G R, et al. J. Mater. Sci.:Mater. Med., 2010, 21:1875-1880 doi: 10.1007/s10856-010-4038-0
17. [17]
  Yang H, Hao L J, Zhao N R, et al. CrystEngComm, 2013, 15:5760-5763 doi: 10.1039/c3ce40710a
18. [18]
  Wan Y Z, Wu C Q, Zuo G F, et al. Mater. Chem. Phys., 2015, 156:238-246 doi: 10.1016/j.matchemphys.2015.03.011
19. [19]
  Ma J, Wang Y, Zhou L, et al. Mater. Sci. Eng. C:Mater. Biol. Appl., 2013, 33:440-445 doi: 10.1016/j.msec.2012.09.011
20. [20]
  Wang Y H, Hao H, Liu H M, et al. Adv. Healthcare Mater., 2015, 4:1813-1818 doi: 10.1002/adhm.v4.12
21. [21]
  Qi C, Zhu Y J, Lu B Q, et al. Chem. Eur. J., 2013, 19:5332-5341 doi: 10.1002/chem.201203886
22. [22]
  Wang Q, Huang W H, Wang D P, et al. J. Mater. Sci.:Mater. Med., 2006, 17:641-646 doi: 10.1007/s10856-006-9227-5
23. [23]
  Yu Y D, Zhu Y J, Qi C, et al. J. Colloid Interface Sci., 2017, 496:416-424 doi: 10.1016/j.jcis.2017.02.041
24. [24]
  Fu H L, Rahaman M N, Day D E, et al. J. Mater. Sci.:Mater. Med., 2011, 22:579-591
25. [25]
  Feng D S, Shi J, Wang X J, et al. RSC Adv., 2013, 3:24975-24982 doi: 10.1039/c3ra44609c
26. [26]
  Zhong Q, Li W, Su X, et al. Colloids Surf. B, 2016, 143:56-63 doi: 10.1016/j.colsurfb.2016.03.020
27. [27]
  Xiao W, Bal B S, Rahaman M N. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 60:324-332 doi: 10.1016/j.msec.2015.11.039
28. [28]
  Xiao Q, Zhou K, Chen C, et al. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 69:1068-1074 doi: 10.1016/j.msec.2016.07.082
29. [29]
  Ma M Y, Zhu Y J, Li L, et al. J. Mater. Chem., 2008, 18:2722-2727 doi: 10.1039/b800389k
30. [30]
  Ye F, Guo H F, Zhang H J, et al. Acta Biomater., 2010, 6:2212-2218 doi: 10.1016/j.actbio.2009.12.014
31. [31]
  Qi C, Zhu Y J, Lu B Q, et al. J. Mater. Chem., 2012, 22:22642-22650 doi: 10.1039/c2jm35280j
32. [32]
  Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, et al. Molecules, 2016, 21:264-285 doi: 10.3390/molecules21030264
33. [33]
  Sarika P R, Nirmala R J. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 65:331-337 doi: 10.1016/j.msec.2016.04.044
34. [34]
  Chen P, Wang H, Yang F, et al. J. Cell Biochem., 2017, 118:74-81 doi: 10.1002/jcb.v118.1
35. [35]
  Sahebkar A. Integr. Cancer Ther., 2016, 15:333-334 doi: 10.1177/1534735415624139
36. [36]
  Shi J, Qi W, Du C, et al. J. Appl. Polym. Sci., 2013, 129:577-584 doi: 10.1002/app.38718
37. [37]
  Pizzoccaro M A, Nikel O, Sene S, et al. Acta Biomater., 2016, 41:342-350 doi: 10.1016/j.actbio.2016.06.008
38. [38]
  DAI Zhao, WANG Da-Lin. Chinese Journal of Tissue Engineering Research, 2018, 22(6):938-944 doi: 10.3969/j.issn.2095-4344.0072
1. [1]
  Rui Li , Ruijie Lu , Libin Yang , Jianwen Li , Zige Guo , Qiquan Yan , Mengjun Li , Yazhuo Ni , Keying Chen , Yaoyang Li , Bo Xu , Mengzhen Cui , Zhan Li , Zhiying Zhao . Immobilization of chitosan nano-hydroxyapatite alendronate composite microspheres on polyetheretherketone surface to enhance osseointegration by inhibiting osteoclastogenesis and promoting osteogenesis. Chinese Chemical Letters, 2025, 36(4): 110242-. doi: 10.1016/j.cclet.2024.110242
2. [2]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
3. [3]
  Ying Xu , Chengying Shen , Hailong Yuan , Wei Wu . Mapping multiple phases in curcumin binary solid dispersions by fluorescence contrasting. Chinese Chemical Letters, 2024, 35(9): 109324-. doi: 10.1016/j.cclet.2023.109324
4. [4]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
5. [5]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
6. [6]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
7. [7]
  Qi Huang , Jun Liao , Jingjing Li , Zhengyan Gu , Xinkang Zhang , Mingxue Sun , Wenqi Meng , Guanchao Mao , Zhipeng Pei , Shanshan Zhang , Songling Li , Chuan Zhang , Yunqin Wang , Jihao Liu , Tingbin Shu , Min Tao , Ying Lu , Kai Xiao , Qingqiang Xu , Jincai Lu . Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury. Chinese Chemical Letters, 2025, 36(4): 109914-. doi: 10.1016/j.cclet.2024.109914
8. [8]
  Jiahui Li , Qiao Shi , Ying Xue , Mingde Zheng , Long Liu , Tuoyu Geng , Daoqing Gong , Minmeng Zhao . The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers. Chinese Chemical Letters, 2024, 35(6): 109239-. doi: 10.1016/j.cclet.2023.109239
9. [9]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018
10. [10]
  Lu Huang , Jiang Wang , Hong Jiang , Lanfang Chen , Huanwen Chen . On-line determination of selenium compounds in tea infusion by extractive electrospray ionization mass spectrometry combined with a heating reaction device. Chinese Chemical Letters, 2025, 36(1): 109896-. doi: 10.1016/j.cclet.2024.109896
11. [11]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
12. [12]
  Yufeng Wu , Mingjun Jing , Juan Li , Wenhui Deng , Mingguang Yi , Zhanpeng Chen , Meixia Yang , Jinyang Wu , Xinkai Xu , Yanson Bai , Xiaoqing Zou , Tianjing Wu , Xianyou Wang . Collaborative integration of Fe-N_x active center into defective sulfur/selenium-doped carbon for efficient oxygen electrocatalysts in liquid and flexible Zn-air batteries. Chinese Chemical Letters, 2024, 35(9): 109269-. doi: 10.1016/j.cclet.2023.109269
13. [13]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
14. [14]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
15. [15]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
16. [16]
  Linjie Ju , Zhongxi Huang , Qian Shen , Chan Fu , Shuanghe Li , Wenjie Duan , Chenfeng Xu , Weizhen An , Zhiqiang Zhai , Jifu Wei , Changmin Yu , Guoren Zhou . Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy. Chinese Chemical Letters, 2024, 35(10): 109450-. doi: 10.1016/j.cclet.2023.109450
17. [17]
  Yu ZHANG , Fangfang ZHAO , Cong PAN , Peng WANG , Liangming WEI . Application of double-side modified separator with hollow carbon material in high-performance Li-S battery. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1218-1232. doi: 10.11862/CJIC.20230412
18. [18]
  Sifan Du , Yuan Wang , Fulin Wang , Tianyu Wang , Li Zhang , Minghua Liu . Evolution of hollow nanosphere to microtube in the self-assembly of chiral dansyl derivatives and inversed circularly polarized luminescence. Chinese Chemical Letters, 2024, 35(7): 109256-. doi: 10.1016/j.cclet.2023.109256
19. [19]
  Jiaxu Wang , Jinxie Zhang , Xiuping Wang , Jingying Wang , Lina Chen , Jiahui Cao , Wei Cao , Siyu Liang , Ping Luan , Ke Zheng , Xiao-Kun Ouyang , Li Gao , Xiaowen Ou , Fan Zhang , Meitong Ou , Lin Mei . CaCO₃-coated hollow mesoporous silica nanoparticles for pH-responsive fungicides release. Chinese Chemical Letters, 2024, 35(12): 109697-. doi: 10.1016/j.cclet.2024.109697
20. [20]
  Xueyan Zhang , Jicong Chen , Songren Han , Shiyan Dong , Huan Zhang , Yuhong Man , Jie Yang , Ye Bi , Lesheng Teng . The size-switchable microspheres co-loaded with RANK siRNA and salmon calcitonin for osteoporosis therapy. Chinese Chemical Letters, 2024, 35(12): 109668-. doi: 10.1016/j.cclet.2024.109668

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(1867)
HTML views(78)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142