Citation: YANG Yong-Mei, JI Ming-Xiang, YANG Ying, XIE An-Jian, SHEN Yu-Hua. Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe₃O₄@mSiO₂ Drug Carriers[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(6): 1095-1102. doi: 10.11862/CJIC.2018.164 shu

Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe₃O₄@mSiO₂ Drug Carriers

1.
School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China
2.
School of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui 245041, China

Corresponding author: SHEN Yu-Hua, s_yuhua@163.com
Received Date: 16 March 2018
Revised Date: 17 April 2018

Figures(8)

A novel sandwich-like nanocomposites of rGO/Fe₃O₄@mSiO₂ were successfully fabricated through a facile method. The morphology and properties of nanocomposites were characterized by SEM, TEM, FTIR, XRD and N₂ adsorption-desorption. As a result, it was observed that the nanocomposites exhibit the saturation magnetization of 32 emu·g^-1, and possess abundant pores with a large surface area as much as 217 m²·g^-1. The loading capacity of Pentafluorouracil (5-FU) with the nanocomposites was high(57.34%). The formation mechanism of rGO/Fe₃O₄@mSiO₂ was discussed. Additionally, the synergistic anticancer efficacy of as-prepared nanocomposites against HeLa cell line was investigated by MTT assay and cell fluorescence microscopic imaging analysis. The results indicated that 5-FU loaded in the nanocoposites is effectively delivered to tumor lesion sites under the action of magnetic targeting. Moreover, the rGO/Fe₃O₄@mSiO₂ nanocomposites have excellent photothermal conversion properties under light conditions, and show significant killing effect on HeLa cells.
- nanocomposite,
- magnetic targeting,
- photo-thermal therapy,
- drug carrier,
- synergistic anti-cancer
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沈阳化工大学材料科学与工程学院沈阳 110142

Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers

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通讯作者: 陈斌, bchen63@163.com

Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe₃O₄@mSiO₂ Drug Carriers