Citation: FENG Yong-Lan, KUANG Dai-Zhi, ZHANG Fu-Xing, YU Jiang-Xi, JIANG Wu-Jiu, ZHU Xiao-Ming. Two Di-n-butyltin Carboxylates with a Sn₄O₄ Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities[J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(5): 830-836. doi: 10.11862/CJIC.2017.107 shu

Two Di-n-butyltin Carboxylates with a Sn₄O₄ Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities

Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China

Corresponding author: KUANG Dai-Zhi, hnkcq@qq.com
Received Date: 7 November 2016
Revised Date: 8 April 2017

Figures(3)

Two di-n-butyltin carboxylates with a Sn₄O₄ ladder-like framework, [(μ₃-O)(μ₂-OMe)(n-Bu₂Sn)₂(O₂CR)]₂ (R=4-methylphenyl (1), 4-(dimethylamino) phenyl (2)), were obtained by the microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the 4-methylbenzoic acid, 4-dimethylaminobenzoic acid in methanol environments, respectively. The compounds were characterized by elemental analysis, IR, (¹H, ¹³C and ¹¹⁹Sn) NMR spectra and X-ray crystallography diffraction analyses. The compounds have similar structures containing a Sn₄O₄ ladder-like skeleton, in which two endo-cyclic tin and one exo-tin atoms is bonded to the μ₃-O atom, in addition, one endo-cyclic tin and one exo-tin atoms is bonded to the μ₂-O atom from the methanol, respectively. The ladder-like molecule has a three-ring fused skeleton, which is almost coplanar. The endo-cyclic and exo-cyclic tin atoms all are five-coordinated with distorted trigonal bipyramid geometry. The antitumor activity shows that compounds 1 and 2 have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.
- organotin compound,
- microwave solvothermal synthesis,
- ladder-like framework,
- in vitro antitumor activity
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Two Di-n-butyltin Carboxylates with a Sn4O4 Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities

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通讯作者: 陈斌, bchen63@163.com

Two Di-n-butyltin Carboxylates with a Sn₄O₄ Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities