Citation: ZHANG Chang-Li, TIAN Jia-Jin, SHAO Yang, XU Jian. Benzothiazole-Based Zn²⁺-Specific Fluorescent Probe and Its Cell Imaging Application[J]. Chinese Journal of Inorganic Chemistry, ;2016, 32(12): 2069-2074. doi: 10.11862/CJIC.2016.274 shu

Benzothiazole-Based Zn²⁺-Specific Fluorescent Probe and Its Cell Imaging Application

ZHANG Chang-Li ^1,2,, ,
TIAN Jia-Jin ¹ ,
SHAO Yang ¹ ,
XU Jian ¹

1.
1 School of Environmental Science, Nanjing Xiaozhuang College, Nanjing 210017, China;
2.
2 State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210023, China

Corresponding author: ZHANG Chang-Li,
Received Date: 11 April 2016
Available Online: 1 October 2016
Fund Project:

A fluorescent probe 2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-5-(diethylamino)phenol (BHP) was designed and synthesized as a Zn²⁺ selective fluorescent chemosensor. It demonstrates Zn²⁺-specific emission enhancement, while many other ions such as Cd²⁺, Fe²⁺, Ni²⁺, Pb²⁺, Hg²⁺, Al³⁺, Mn²⁺, Ag⁺, Cu²⁺, Co²⁺, Na⁺, K⁺, Mg²⁺ and Ca²⁺, have no response. Notably, this chemosensor can distinguish Zn²⁺ from Cd²⁺. Its binding stoichiometry with Zn²⁺ is 1:1 ratio. Its pH-independent Zn²⁺-induced emission enhancement in physiological condition and cell permeability make it an effective intracellular Zn²⁺ imaging agent.
- zinc ion;cadmium ion;fluorescent sensor;imaging
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沈阳化工大学材料科学与工程学院沈阳 110142

Benzothiazole-Based Zn2+-Specific Fluorescent Probe and Its Cell Imaging Application

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通讯作者: 陈斌, bchen63@163.com

Benzothiazole-Based Zn²⁺-Specific Fluorescent Probe and Its Cell Imaging Application