Citation: FENG Yong-Lan, YU Jiang-Xi, KUANG Dai-Zhi, TAN Yu-Xing, ZHANG Fu-Xing, JIANG Wu-Jiu, ZHU Xiao-Ming, ZHENG Jian-Hua. Syntheses, Crystal Structures, Anti-tumor Activity and Thermal Stability of Tri-alkyltin Cinnamic Carboxylates[J]. Chinese Journal of Inorganic Chemistry, ;2015, (5): 908-914. doi: 10.11862/CJIC.2015.109 shu

Syntheses, Crystal Structures, Anti-tumor Activity and Thermal Stability of Tri-alkyltin Cinnamic Carboxylates

1.
1 Key Laboratory of Functional Organometallic Materials of College of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China;
2.
2 College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China

Corresponding author: KUANG Dai-Zhi,
Received Date: 12 November 2014
Available Online: 11 January 2014
Fund Project: 湖南省自然科学基金(No.13JJ3112) (No.13JJ3112)湖南省科技计划(No.2014NK3086) (No.2014NK3086)湖南省高校创新平台开放基金(No.13K105,14K014) (No.13K105,14K014)重点实验室开放基金(No.13K01,GN14K01) (No.13K01,GN14K01)湖南省十二五重点建设学科(材料物理与化学) (材料物理与化学)衡阳师范学院协同创新中心培育项目(No.12XT02) (No.12XT02)青年骨干教师培养计划(2012) (2012)湖南省大学生研究性学习项目(CX1301)资助。 (CX1301)

Two trialkyltin carboxylates [n-Bu₃Sn(O₂CC₈H₇)]_n (1) and Cy₃Sn(O₂CC₈H₇)·MeOH (2) were synthesized by the reactions of cinnamic acid with bis(tributyltin) oxide and tricyclohexyltin hydroxide, respectively. Their structures were characterized by IR, ¹H and ¹³C NMR, elemental analysis and X-ray crystal diffraction. The crystal of complex 1 belongs to monoclinic system, space group P2₁/c, a=1.05381(2) nm, b=1.85066(4) nm, c=2.49500(5) nm, β=106.3460(10)°, V=4.66918(16) nm³, Z=4, D_c=1.244 g·cm^-3, μ(Mo Kα)=1.103 mm^-1, F(000)= 1808, R₁=0.0519, wR₂=0.1320. The crystal of complex 2 belongs to triclinic system, space group P1, a=1.3388(3) nm, b=1.4926(4) nm, c=1.7884(5) nm, α=67.066(14)°, β=69.631(15)°, γ=63.938(14)°, V=2.8882(13) nm³, Z=4, D_c=1.259 g·cm^-3, μ(Mo Kα)=0.908 mm^-1, F(000)=1144, R₁=0.0506, wR₂=0.1102. The central tin atoms of two complexes are aberrant trigonal bipyramidal configurations with five coordination, and a 1Dinfinite chain of 1 is bridged by carboxyl Oatoms, while a 2D network of 2 is generated by O-H…O hydrogen bonds and π-π effects. Moreover, the preliminary tests showed that complex 1 displayed stronger than carboplatin in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and had higher medicinal value than complex 2. Thermogravimetric analysis shows the complexes were stable up to 145 or 190 ℃, respectively.
- trialkyltin;cinnamic acid;crystal structure;anti-tumor activity
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