Citation: FENG Yong-Lan, YU Jiang-Xi, KUANG Dai-Zhi, TAN Yu-Xing, ZHANG Fu-Xing, JIANG Wu-Jiu, ZHU Xiao-Ming, ZHENG Jian-Hua. Syntheses, Crystal Structures, and Anti-tumor Activity of Tetra-nuclear Cluster and 1D Chain Butyltin α-Naphthaleneacetic Carboxylates[J]. Chinese Journal of Inorganic Chemistry, ;2015, (4): 710-716. doi: 10.11862/CJIC.2015.041 shu

Syntheses, Crystal Structures, and Anti-tumor Activity of Tetra-nuclear Cluster and 1D Chain Butyltin α-Naphthaleneacetic Carboxylates

1.
1 Key Laboratory of Functional Organometallic Materials of College of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China;
2.
2 College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China

Corresponding author: KUANG Dai-Zhi,
Received Date: 27 October 2014
Available Online: 25 November 2014
Fund Project: 湖南省自然科学基金(No.13JJ3112) (No.13JJ3112)湖南省科技计划(No.2014NK3086) (No.2014NK3086)湖南省高校创新平台开放基金(No.13K105,14K014,GN14K01) (No.13K105,14K014,GN14K01) 衡阳师范学院协同创新中心培育项目(No.12XT02) (No.12XT02)青年骨干教师培养计划(2012) (2012)国家级大学生创业训练计划(No.201310546127) (No.201310546127)湖南省大学生研究性学习项目(No.CX1301)资助项目。 (No.CX1301)

The tetra-nuclear cluster dibutyltin α-naphthaleneacetic carboxylate {[n-Bu₂Sn(O₂CCH₂C₁₀H₇)]₂O}₂ (1) and the 1D chain tributyltin α-naphthaleneacetic carboxylate [n-Bu₃Sn(O₂CCH₂C₁₀H₇)]_n (2) were synthesized by the reactions of α-naphthaleneacetic acid with dibutyltin oxide and bis(tributyltin) oxide under the same conditions, respectively. Their structures were characterized by IR, ¹H and ¹³C NMR, elemental analysis and X-ray crystal diffraction. The core structures of 1 are two Sn₂O₂ four-membered rings which are constructed of Sn atoms with O bridges, and the two Sn₂O₂ units are dimerized to a Sn₄O₄ cluster, so the center of central Sn₂O₂ ring coincides with the symmetry center of whole molecule. Due to the C-H…π interactions, the adjacent molecules of complex 1 is linked to generate 1D ribbon structure. For complex 2, two Sn atoms are bridged by two O atoms of a carboxylate ligand to form 1D infinite chain coordination polymer. Thermogravimetric analysis shows the complexes were stable up to 250 or 175℃, respectively. Moreover, the tests showed that both of them displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, but the activity order is 2 >1. CCDC: 1026774, 1; 1026775, 2.
- organotin;solvothermal synthesis;crystal structure;anti-tumor activity
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