Citation: JIAO Yuan-Hong, ZHANG Qian, JIANG Yu-Feng, ZHANG Wan-Ju. A Benzothiazole-Derived Fluorescent Probe for Detecting Hg(Ⅱ) in Live Cells[J]. Chinese Journal of Inorganic Chemistry, ;2015, (2): 361-368. doi: 10.11862/CJIC.2015.019 shu

A Benzothiazole-Derived Fluorescent Probe for Detecting Hg(Ⅱ) in Live Cells

1.
1. College of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi, Hubei 435003, China;
2.
2. Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal University, Huanggang, Hubei 438000, China;
3.
3. Hubei Key Laboratory of Mine Environmental Pollution Control & Remediation, Hubei Polytechnic University, Huangshi, Hubei 435003, China

Corresponding author: ZHANG Wan-Ju,
Received Date: 29 August 2014
Available Online: 25 October 2014
Fund Project: 湖北省教育厅B类项目(No.B20114404) (No.B20114404)矿区环境污染控制与修复湖北省重点实验室开放基金项目(No.2012103) (No.2012103)湖北省教育厅青年人才资助项目(No.Q20132901) (No.Q20132901)

Abenzothiazole-derived fluorescent probe (YH1) has been synthesized and structurally characterized, and its response to different metal ions has been investigated by spectrometry. The results showed that YH1 exhibited good sensitivity and selectivity to Hg²⁺. Its interaction with Hg²⁺ caused the color of its solution changed from blue to colorless under UVirradiation. There was a good linear relationship between the fluorescence intensity of YH1 and the concentration of Hg²⁺ in the range of 1.4 μmol·L^-1 to 8.8 μmol·L^-1, and its detection limit for Hg²⁺ was 0.56 μmol·L^-1. Moreover, the cell membrane penetration of YH1 had low cytotoxicity, and it can be applied to image intracellular Hg²⁺ in living HeLa cells. CCDC: 978108.
- crystal structure;Hg²⁺;fluorescent probe;benzothiazole;fluorescent imaging
1. [1]
  [1] Nolan E M, Lipard S J. Chem. Rev., 2008,108:3443-3480
2. [2]
  [2] Guo Z Q, Park S, Yoon J, et al. Chem. Soc. Rev., 2014,43: 16-29
3. [3]
  [3] Li X H, Gao X H, Shi W, et al. Chem. Rev., 2014,114:590-659
4. [4]
  [4] Guo Z Q, Zhu W H, Zhu M M, et al. Chem. Eur. J., 2010, 16:14424-14432
5. [5]
  [5] Tong S, Zhang L, Bing L, et al. Sensor Actuators B: Chem., 2014,203:157-164
6. [6]
  [6] Nolan E M, Racine M E, Lippard S J. Inorg. Chem., 2006, 45:2742-2749
7. [7]
  [7] Shi H F, Liu S J, Sun H B, et al. Chem. Eur. J., 2010,16: 12158-12167
8. [8]
  [8] Tsukamoto K, Shinohara Y, Iwasakia S, et al. Chem. Commun., 2011,47:5073-5075
9. [9]
  [9] Zhao Q, Liu S J, Li F Y, et al. Dalton Trans., 2008:3836-3840
10. [10]
  [10] Tayade K, Bondhopadhyay B, Basu A, et al. Talanta, 2014, 122:16-22
11. [11]
  [11] Sun H B, Liu S J, Ma T C, et al. New J. Chem., 2011,35: 1194-1197
12. [12]
  [12] Wanichacheva N, Watpathomsub S, Lee V S, et al. Molecules, 2010,15:1798-1810
13. [13]
  [13] Zhao Q, Cao T Y, Li F Y, et al. Organometallics, 2007,26: 2077-2081
14. [14]
  [14] Jeong H J, Li Y, Hyun M H. Bull. Korean Chem. Soc., 2011,32:2809-2812
15. [15]
  [15] Tsukamoto K, Shinohara Y, Iwasakia S, et al. Chem. Commun., 2011,47:5073-5075
16. [16]
  [16] Kim S H, Kim J S, Park S M, et al. Org. Lett., 2006,8:371-374
17. [17]
  [17] Kim S H, Youn N J, Park J Y, et al. Bull. Korean Chem. Soc., 2006,27:1553-1156
18. [18]
  [18] Sakamoto H, Ishikawa J, Nakao S, et al. Chem. Commun., 2000:2395-2396
19. [19]
  [19] Santra M, Roy B, Ahn K H. Org. Lett., 2011,13:3422-3425
20. [20]
  [20] Sun W, Li W H, Li J, et al. Tetrahedron Lett., 2012,53: 2332-2335
21. [21]
  [21] ZHANG Yong(张勇), WANG Qiang(王强), LI Wei(李伟), et al. Chin. J. Org. Chem.(有机化学), 2014,34(2):403-408
22. [22]
  [22] Sheldrick G M. SHELXS-97, Program for the Solution of Crystal Structures, University of Göttingen, Germany, 1997.
23. [23]
  [23] Sheldrick G M. SHELXL-97, Program for the Refinement of Crystal Structures, University of Göttingen, Germany, 1997.
24. [24]
  [24] Shortreed M, Kopelman R, Kuhn M, et al. Anal. Chem., 1996,68:1414-1418
25. [25]
  [25] Benesi H A, Hildebrand J H. J. Am. Chem. Soc., 1949,71: 2703-2707
26. [26]
  [26] Jeong H J, Li Y, Hyun M H. Bull. Korean Chem. Soc., 2011,32:2809-2812
1. [1]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
2. [2]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
3. [3]
  Jun LUO , Baoshu LIU , Yunchang ZHANG , Bingkai WANG , Beibei GUO , Lan SHE , Tianheng CHEN . Europium(Ⅲ) metal-organic framework as a fluorescent probe for selectively and sensitively sensing Pb²⁺ in aqueous solution. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2438-2444. doi: 10.11862/CJIC.20240240
4. [4]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
5. [5]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
6. [6]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
7. [7]
  Yan Liu , Yuexiang Zhu , Luhua Lai . Introduction to Blended and Small-Class Teaching in Structural Chemistry: Exploring the Structure and Properties of Crystals. University Chemistry, 2024, 39(3): 1-4. doi: 10.3866/PKU.DXHX202306084
8. [8]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
9. [9]
  Weina Wang , Fengyi Liu , Wenliang Wang . “Extracting Commonality, Delving into Typicals, Deriving Individuality”: Constructing a Knowledge Graph of Crystal Structures. University Chemistry, 2024, 39(3): 36-42. doi: 10.3866/PKU.DXHX202308029
10. [10]
  Junqiao Zhuo , Xinchen Huang , Qi Wang . Symbol Representation of the Packing-Filling Model of the Crystal Structure and Its Application. University Chemistry, 2024, 39(3): 70-77. doi: 10.3866/PKU.DXHX202311100
11. [11]
  Changqing MIAO , Fengjiao CHEN , Wenyu LI , Shujie WEI , Yuqing YAO , Keyi WANG , Ni WANG , Xiaoyan XIN , Ming FANG . Crystal structures, DNA action, and antibacterial activities of three tetranuclear lanthanide-based complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2455-2465. doi: 10.11862/CJIC.20240192
12. [12]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
13. [13]
  Wenyan Dan , Weijie Li , Xiaogang Wang . The Technical Analysis of Visual Software ShelXle for Refinement of Small Molecular Crystal Structure. University Chemistry, 2024, 39(3): 63-69. doi: 10.3866/PKU.DXHX202302060
14. [14]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
15. [15]
  Yuyao Wang , Zhitao Cao , Zeyu Du , Xinxin Cao , Shuquan Liang . Research Progress of Iron-based Polyanionic Cathode Materials for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100035-. doi: 10.3866/PKU.WHXB202406014
16. [16]
  Yu SU , Xinlian FAN , Yao YIN , Lin WANG . From synthesis to application: Development and prospects of InP quantum dots. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2105-2123. doi: 10.11862/CJIC.20240126
17. [17]
  Jingjing QING , Fan HE , Zhihui LIU , Shuaipeng HOU , Ya LIU , Yifan JIANG , Mengting TAN , Lifang HE , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003
18. [18]
  Liyang ZHANG , Dongdong YANG , Ning LI , Yuanyu YANG , Qi MA . Crystal structures, luminescent properties and Hirshfeld surface analyses of three cadmium(Ⅱ) complexes based on 2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)benzoate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1943-1952. doi: 10.11862/CJIC.20240079
19. [19]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
20. [20]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(188)
HTML views(2)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142