Citation: FAN Shao-Yong, HUANG Ke-Di, TANG Qing-Mei, HUANG Zhi-Rong, AI Fan-Rong, CHEN Wei-Gao, YAN Xi-Luan. Heat Generation Abilities of Magnetic Thermosensitive Composite Particles for Hyperthermia and Chemotherapy Application[J]. Chinese Journal of Inorganic Chemistry, ;2014, 30(5): 1167-1173. doi: 10.11862/CJIC.2014.123 shu

Heat Generation Abilities of Magnetic Thermosensitive Composite Particles for Hyperthermia and Chemotherapy Application

1.
1 Nanchang University, Nanchang Jiangxi, 330031, China;

Received Date: 5 August 2013
Available Online: 19 December 2013
Fund Project: 国家自然科学基金(No.51102131，81102289)资助项目。 (No.51102131，81102289)

Fe₃O₄/P(N-isopropylacrylamide-co-acrylamide) [P(NIPAAm-co-Am)], magnetic thermosensitive composite particles were prepared by emulsifier free polymerization. The structure and morphology of the as-synthesized composite particles were characterized by using TEM, and the magnetic and thermosensitive properties were investigated by Vibrating Sample Magnetometer (VSM) and Dynamic Light Scattering (DLS). In addition, the heat generation ability of the composite particles was investigated under alternating magnetic field. The results show that Fe₃O₄ nanoparticles are coated by a thermosensitive P(NIPAAm-co-Am) with an LCSTabout 40 ℃. The composite particles exhibit relatively high magnetic property and heat generation ability. Furthermore, the heat generation ability of the composite particles under alternating magnetic field can be adjusted by controlling the concentration of composite particles and/or the magnetic field.
- magnetic nanoparticles;thermosensitive hydrogel;hyperthermia;chemotherapy;drug release
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