Citation: REN Jin-Qi, JIAO Qing-Zhu, WANG Yi-Nuo, XU Fang-Yuan, CHENG Xiao-Shao, YOU Zhong-Lu. Synthesis, Structures and Helicobacter Pylori Urease Inhibition of Schiff Base Vanadium Complexes Containing Acetohydroxamate Ligands[J]. Chinese Journal of Inorganic Chemistry, ;2014, 30(3): 640-648. doi: 10.11862/CJIC.2014.106 shu

Synthesis, Structures and Helicobacter Pylori Urease Inhibition of Schiff Base Vanadium Complexes Containing Acetohydroxamate Ligands

1.
1 Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China;

Received Date: 21 September 2013
Available Online: 14 November 2013
Fund Project: 辽宁省高校优秀青年人才支持计划(No.LJQ2011114) (No.LJQ2011114)南京大学配位化学国家重点实验室开放课题基金,国家自然科学基金(No.20901036) 资助项目。 (No.20901036)

Two new Schiff base vanadium complexes containing acetohydroxamate ligands, [V^ⅢL¹(HAHA)] (1) and [V^ⅤOL²(AHA)] (2), where L¹ is the dianionic form of N,N'-bis(5-methylsalicylidene)ethane-1, 2-diamine, L² is the monoanionic form of 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-6-methylphenol, HAHA and AHA are the mono-anionic and di-anionic forms of acetohydroxamic acid, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The V atoms in the complexes adopt octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition of complexes 1 and 2 at the concentration of 100 μmol·L^-1 on Helicobacter pylori urease are 37.2% and 81.5%, respectively. Complex 2 has IC50 value of 21.5 μmol·L^-1. Molecular docking study indicates that there form effective interactions between complex 2 and the active site of the urease. CCDC: 961635, 1; 961636, 2.
- schiff base;acetohydroxamate;vanadium complex;crystal structure;urease inhibitor
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