Citation: JIANG Jing, LOU Li-Guang, CHEN Xi-Zhu, XU Yong-Ping, YE Qing-Song, LIU Wei-Ping. Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin[J]. Chinese Journal of Inorganic Chemistry, ;2014, (2): 317-322. doi: 10.11862/CJIC.2014.008 shu

Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin

1.
1 State Key Lab for Platinum Group Metals, Kunming Institute of Precious Metals, Kunming 650106, China;

Corresponding author: LIU Wei-Ping,
Received Date: 14 June 2013
Available Online: 1 August 2013
Fund Project:

Two water-soluble derivatives of heptaplatin, cis-[(4R,5R)-4,5-bis(aminomethyl)-2-R-1,3-dioxolane](3-hydroxy^-1,1-cyclobutanedicarboxylato) platinum(Ⅱ) (R=ethyl and methyl), were synthesized and characterized by elemental analysis, FAB⁺-MS and FT-IRalong with ¹³C NMR. They were evaluated for the cytotoxicity against three human cancer cell lines and for the antitumor activity in the murine S180 model. The results show that despite their cytotoxic potency slightly lower than that of heptaplatin, the derivatives exhibits higher antitumor activity and are worthy of further research.
- platinum complexes;synthesis;anti-tumor
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沈阳化工大学材料科学与工程学院沈阳 110142