Citation: Yong-san Li, Yan-shuang Xu, Lei Tao, Yen Wei. Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels[J]. Acta Polymerica Sinica, ;2020, 51(1): 30-38. doi: 10.11777/j.issn1000-3304.2020.19144 shu

Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education),Department of Chemistry, Tsinghua University, Beijing 100084

Corresponding author: Lei Tao, leitao@mail.tsinghua.edu.cn Yen Wei, weiyen@tsinghua.edu.cn
Received Date: 2 August 2019
Revised Date: 29 August 2019
Available Online: 14 October 2019

Self-healing hydrogel is a new generation smart material that has drawn great attention among researchers from multiple cutting edge areas. Self-healing hydrogels are continuously enriching our knowledge in developing new materials and changing our lives. In the recent decades, thanks to numerous dedicated researchers, series of self-healing hydrogels have been explored through dynamic chemistry and supramolecular interactions, which have been applied in interdisciplinary areas for controlled release of drugs, 3D cell culture, and scaffolds of tissue engineering, etc. Self-healing hydrogels can be injected as solid gels instead of liquid precursor, then self-heal in situ. Thus, self-healing hydrogels have been utilized as a new type of injectable carrier to deliver drugs. This method effectively avoids unwanted cargo loss throughout the cycling and dramatically improves the delivery efficiency of drugs. Thus, self-healing hydrogels have been studied in recent research as great therapeutic carrier for tumour therapy and wound-healing. This review aims to summarize some recent research progresses in the preparation of self-healing hydrogels based on different dynamic covalent bonds. The bio-medical applications of self-healing hydrogels including tumour therapy and wound-healing have also been introduced. The future development and challenges of dynamic chemistry based on self-healing hydrogels have also been discussed.
- Dynamic covalent bond,
- Self-healing hydrogel,
- Drug carrier
1. [1]
  Ahmed E M. J Adv Res, 2015, 6(2): 105 − 121 doi: 10.1016/j.jare.2013.07.006
2. [2]
  Li J, Mooney D J. Nat Rev Mater, 2016, 1: 16071 doi: 10.1038/natrevmats.2016.71
3. [3]
  Hoare T R, Kohane D S. Polymer, 2008, 49(8): 1993 − 2007 doi: 10.1016/j.polymer.2008.01.027
4. [4]
  Qiu Y, Park K. Adv Drug Delivery Rev, 2001, 53(3): 321 − 339 doi: 10.1016/S0169-409X(01)00203-4
5. [5]
  Culver H R, Clegg J R, Peppas N A. Acc Chem Res, 2017, 50(2): 170 − 178 doi: 10.1021/acs.accounts.6b00533
6. [6]
  Hu J, Chen Y, Li Y, Zhou Z, Cheng Y. Biomaterials, 2017, 112: 133 − 140 doi: 10.1016/j.biomaterials.2016.10.015
7. [7]
  Ravi M, Paramesh V, Kaviya S R, Anuradha E, Solomon F D P. J Cell Physiol, 2015, 230(1): 16 − 26 doi: 10.1002/jcp.24683
8. [8]
  Huang Q, Zou Y, Arno M C, Chen S, Wang T, Gao J, Dove A P, Du J. Chem Soc Rev, 2017, 46(20): 6255 − 6275 doi: 10.1039/C6CS00052E
9. [9]
  Caliari S R, Burdick J A. Nat Meth, 2016, 13: 405 doi: 10.1038/nmeth.3839
10. [10]
  Lou J, Stowers R, Nam S, Xia Y, Chaudhuri O. Biomaterials, 2018, 154: 213 − 222 doi: 10.1016/j.biomaterials.2017.11.004
11. [11]
  Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif S A, Weaver J C, Huebsch N, Lee H P, Lippens E, Duda G N, Mooney D J. Nat Mater, 2015, 15: 326
12. [12]
  Ren K, He C, Xiao C, Li G, Chen X. Biomaterials, 2015, 51: 238 − 249 doi: 10.1016/j.biomaterials.2015.02.026
13. [13]
  Xavier J R, Thakur T, Desai P, Jaiswal M K, Sears N, Cosgriff-Hernandez E, Kaunas R, Gaharwar A K. ACS Nano, 2015, 9(3): 3109 − 3118 doi: 10.1021/nn507488s
14. [14]
  Yang J, Zhang Y S, Yue K, Khademhosseini A. Acta Biomater, 2017, 57: 1 − 25 doi: 10.1016/j.actbio.2017.01.036
15. [15]
  Wang H, Heilshorn S C. Adv Mater, 2015, 27(25): 3717 − 3736 doi: 10.1002/adma.201501558
16. [16]
  Liu M, Zeng X, Ma C, Yi H, Ali Z, Mou X, Li S, Deng Y, He N. Bone Res, 2017, 5: 17014 doi: 10.1038/boneres.2017.14
17. [17]
  Tseng T C, Tao L, Hsieh F Y, Wei Y, Chiu I M, Hsu S H. Adv Mater, 2015, 27(23): 3518 − 3524 doi: 10.1002/adma.201500762
18. [18]
  Cao Q, Wang X, Wu D. Chinese J Polym Sci, 2018, 36(1): 8 − 17 doi: 10.1007/s10118-018-2061-7
19. [19]
  Bu Y, Sun G, Zhang L, Liu J, Yang F, Tang P, Wu D. Chinese J Polym Sci, 2017, 35(10): 1231 − 1242 doi: 10.1007/s10118-017-1958-x
20. [20]
  Yesilyurt V, Webber M J, Appel E A, Godwin C, Langer R, Anderson D G. Adv Mater, 2016, 28(1): 86 − 91 doi: 10.1002/adma.201502902
21. [21]
  Xie W, Gao Q, Guo Z, Wang D, Gao F, Wang X, Wei Y, Zhao L. ACS Appl Mater Interfaces, 2017, 9(39): 33660 − 33673 doi: 10.1021/acsami.7b10699
22. [22]
  Tian R, Qiu X, Yuan P, Lei K, Wang L, Bai Y, Liu S, Chen X. ACS Appl Mater Interfaces, 2018, 10(20): 17018 − 17027 doi: 10.1021/acsami.8b01740
23. [23]
  Pianowski Z L, Karcher J, Schneider K. Chem Commun, 2016, 52(15): 3143 − 3146 doi: 10.1039/C5CC09633B
24. [24]
  Wang C, Liu X, Wulf V, Vázquez-González M, Fadeev M, Willner I. ACS Nano, 2019, 13(3): 3424 − 3433 doi: 10.1021/acsnano.8b09470
25. [25]
  Ganta S, Devalapally H, Shahiwala A, Amiji M. J Control Release, 2008, 126(3): 187 − 204 doi: 10.1016/j.jconrel.2007.12.017
26. [26]
  Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee S K. J Pharm Investig, 2012, 2(1): 2 − 11 doi: 10.4103/2230-973X.96920
27. [27]
  Müller R H, Mäder K, Gohla S. Eur J Pharm Biopharm, 2000, 50(1): 161 − 177 doi: 10.1016/S0939-6411(00)00087-4
28. [28]
  Jeong B, Bae Y H, Kim S W. J Control Release, 2000, 63(1): 155 − 163
29. [29]
  Yu L, Ding J. Chem Soc Rev, 2008, 37(8): 1473 − 1481 doi: 10.1039/b713009k
30. [30]
  Altunbas A, Lee S J, Rajasekaran S A, Schneider J P, Pochan D J. Biomaterials, 2011, 32(25): 5906 − 5914 doi: 10.1016/j.biomaterials.2011.04.069
31. [31]
  Chang G, Ci T, Yu L, Ding J. J Control Release, 2011, 156(1): 21 − 27 doi: 10.1016/j.jconrel.2011.07.008
32. [32]
  Zhao X, Wu H, Guo B, Dong R, Qiu Y, Ma P X. Biomaterials, 2017, 122: 34 − 47 doi: 10.1016/j.biomaterials.2017.01.011
33. [33]
  Wei Z, Yang J H, Liu Z Q, Xu F, Zhou J X, Zrínyi M, Osada Y, Chen Y M. Adv Funct Mater, 2015, 25(9): 1352 − 1359 doi: 10.1002/adfm.201401502
34. [34]
  Zhang Y, Yang B, Zhang X, Xu L, Tao L, Li S, Wei Y. Chem Commun, 2012, 48(74): 9305 − 9307 doi: 10.1039/c2cc34745h
35. [35]
  Yang B, Zhang Y, Zhang X, Tao L, Li S, Wei Y. Polym Chem, 2012, 3(12): 3235 − 3238 doi: 10.1039/c2py20627g
36. [36]
  Ding F, Wu S, Wang S, Xiong Y, Li Y, Li B, Deng H, Du Y, Xiao L, Shi X. Soft Matter, 2015, 11(20): 3971 − 3976 doi: 10.1039/C5SM00587F
37. [37]
  Zhang Y, Tao L, Li S, Wei Y. Biomacromolecules, 2011, 12(8): 2894 − 2901 doi: 10.1021/bm200423f
38. [38]
  Qu J, Zhao X, Liang Y, Zhang T, Ma P X, Guo B. Biomaterials, 2018, 183: 185 − 199 doi: 10.1016/j.biomaterials.2018.08.044
39. [39]
  Lei J, Li X, Wang S, Yuan L, Ge L, Li D, Mu C. ACS Appl Polym Mater, 2019, 1(6): 1350 − 1358 doi: 10.1021/acsapm.9b00143
40. [40]
  Wang Z, Tao F, Pan Q. J Mater Chem A, 2016, 4(45): 17732 − 17739 doi: 10.1039/C6TA08018A
41. [41]
  Lu B, Lin F, Jiang X, Cheng J, Lu Q, Song J, Chen C, Huang B. ACS Sustain Chem Eng, 2017, 5(1): 948 − 956 doi: 10.1021/acssuschemeng.6b02279
42. [42]
  Cai G, Wang J, Qian K, Chen J, Li S, Lee P S. Adv Sci, 2017, 4(2): 1600190 doi: 10.1002/advs.201600190
43. [43]
  He L, Szopinski D, Wu Y, Luinstra G A, Theato P. ACS Macro Lett, 2015, 4(7): 673 − 678 doi: 10.1021/acsmacrolett.5b00336
44. [44]
  Spoljaric S, Salminen A, Luong N D, Seppälä J. Eur Polym J, 2014, 56: 105 − 117 doi: 10.1016/j.eurpolymj.2014.03.009
45. [45]
  Wu Baoyi(吴宝意), Xu Yawen (徐亚文), Le Xiaoxia(乐晓霞), Jian Yukun(简钰坤), Lu Wei(路伟), Zhang Jiawei(张佳玮), Chen Tao(陈涛). Acta Polymerica Sinica(高分子学报), 2019, (5): 496 − 504
46. [46]
  Deng C C, Brooks W L A, Abboud K A, Sumerlin B S. ACS Macro Lett, 2015, 4(2): 220 − 224 doi: 10.1021/acsmacrolett.5b00018
47. [47]
  Smithmyer M E, Deng C C, Cassel S E, LeValley P J, Sumerlin B S, Kloxin A M. ACS Macro Lett, 2018, 7(9): 1105 − 1110 doi: 10.1021/acsmacrolett.8b00462
48. [48]
  Guo R, Su Q, Zhang J, Dong A, Lin C, Zhang J. Biomacromolecules, 2017, 18(4): 1356 − 1364 doi: 10.1021/acs.biomac.7b00089
49. [49]
  Deng G, Li F, Yu H, Liu F, Liu C, Sun W, Jiang H, Chen Y. ACS Macro Lett, 2012, 1(2): 275 − 279 doi: 10.1021/mz200195n
50. [50]
  Amamoto Y, Otsuka H, Takahara A, Matyjaszewski K. Adv Mater, 2012, 24(29): 3975 − 3980 doi: 10.1002/adma.201201928
51. [51]
  Yoon J A, Kamada J, Koynov K, Mohin J, Nicolaÿ R, Zhang Y, Balazs A C, Kowalewski T, Matyjaszewski K. Macromolecules, 2012, 45(1): 142 − 149 doi: 10.1021/ma2015134
52. [52]
  Canadell J, Goossens H, Klumperman B. Macromolecules, 2011, 44(8): 2536 − 2541 doi: 10.1021/ma2001492
53. [53]
  Dou Xueyu(窦雪宇), Wang Xing(王星), Wu Decheng(吴德成). Acta Polymerica Sinica(高分子学报), 2019, (5): 429 − 441 doi: 10.11777/j.issn1000-3304.2019.18263
54. [54]
  Casuso P, Odriozola I, Pérez-San Vicente A, Loinaz I, Cabañero G, Grande H J, Dupin D. Biomacromolecules, 2015, 16(11): 3552 − 3561 doi: 10.1021/acs.biomac.5b00980
55. [55]
  Hou S, Ma P X. Chem Mater, 2015, 27(22): 7627 − 7635 doi: 10.1021/acs.chemmater.5b02839
56. [56]
  Li J, Ejima H, Yoshie N. ACS Appl Mater Interfaces, 2016, 8(29): 19047 − 19053 doi: 10.1021/acsami.6b04075
57. [57]
  Rao Y L, Chortos A, Pfattner R, Lissel F, Chiu Y C, Feig V, Xu J, Kurosawa T, Gu X, Wang C, He M, Chung J W, Bao Z. J Am Chem Soc, 2016, 138(18): 6020 − 6027 doi: 10.1021/jacs.6b02428
58. [58]
  Shao C, Chang H, Wang M, Xu F, Yang J. ACS Appl Mater Interfaces, 2017, 9(34): 28305 − 28318 doi: 10.1021/acsami.7b09614
59. [59]
  Liang H, Zhang Z, Yuan Q, Liu J. Chem Commun, 2015, 51(82): 15196 − 15199 doi: 10.1039/C5CC06824J
60. [60]
  Shi L, Han Y, Hilborn J, Ossipov D. Chem Commun, 2016, 52(74): 11151 − 11154 doi: 10.1039/C6CC05565F
61. [61]
  Krogsgaard M, Behrens M A, Pedersen J S, Birkedal H. Biomacromolecules, 2013, 14(2): 297 − 301 doi: 10.1021/bm301844u
62. [62]
  Holten-Andersen N, Harrington M J, Birkedal H, Lee B P, Messersmith P B, Lee K Y C, Waite J H. Proc Natl Acad Sci USA, 2011, 108(7): 2651 − 2655 doi: 10.1073/pnas.1015862108
63. [63]
  Liu Y L, Chuo T W. Polym Chem, 2013, 4(7): 2194 − 2205 doi: 10.1039/c2py20957h
64. [64]
  Oehlenschlaeger K K, Mueller J O, Brandt J, Hilf S, Lederer A, Wilhelm M, Graf R, Coote M L, Schmidt F G, Barner-Kowollik C. Adv Mater, 2014, 26(21): 3561 − 3566 doi: 10.1002/adma.201306258
65. [65]
  Shao C, Wang M, Chang H, Xu F, Yang J. ACS Sustain Chem Eng, 2017, 5(7): 6167 − 6174 doi: 10.1021/acssuschemeng.7b01060
66. [66]
  Nimmo C M, Owen S C, Shoichet M S. Biomacromolecules, 2011, 12(3): 824 − 830 doi: 10.1021/bm101446k
67. [67]
  Kakuta T, Takashima Y, Nakahata M, Otsubo M, Yamaguchi H, Harada A. Adv Mater, 2013, 25(20): 2849 − 2853 doi: 10.1002/adma.201205321
68. [68]
  Wei Z, Yang J H, Du X J, Xu F, Zrinyi M, Osada Y, Li F, Chen Y M. Macromol Rapid Commun, 2013, 34(18): 1464 − 1470 doi: 10.1002/marc.201300494
69. [69]
  Li Y, Wang X, Wei Y, Tao L. Chinese Chem Lett, 2017, 28(11): 2053 − 2057 doi: 10.1016/j.cclet.2017.09.004
70. [70]
  Yang L, Li Y, Gou Y, Wang X, Zhao X, Tao L. Polym Chem, 2017, 8(34): 5071 − 5076 doi: 10.1039/C7PY00112F
71. [71]
  Li Y, Wang X, Fu Y N, Wei Y, Zhao L, Tao L. ACS Appl Mater Interfaces, 2018, 10(31): 26046 − 26055 doi: 10.1021/acsami.8b08874
72. [72]
  Zhao L, Niu L, Liang H, Tan H, Liu C, Zhu F. ACS Appl Mater Interfaces, 2017, 9(43): 37563 − 37574 doi: 10.1021/acsami.7b09395
73. [73]
  Caló E, Khutoryanskiy V V. Eur Polym J, 2015, 65: 252 − 267 doi: 10.1016/j.eurpolymj.2014.11.024
74. [74]
  Darabi M A, Khosrozadeh A, Mbeleck R, Liu Y, Chang Q, Jiang J, Cai J, Wang Q, Luo G, Xing M. Adv Mater, 2017, 29(31): 1700533 doi: 10.1002/adma.201700533
75. [75]
  Li Y, Yang L, Zeng Y, Wu Y, Wei Y, Tao L. Chem Mater, 2019, 31(15): 5576 − 5583 doi: 10.1021/acs.chemmater.9b01301
76. [76]
  Ding Xiaoya(丁晓亚), Wang Yu(王宇), Li Gao(李杲), Xiao Chunsheng(肖春生), Chen Xuesi(陈学思). Acta Polymerica Sinica(高分子学报), 2019, 50(5): 505 − 515
77. [77]
  Fu C, Wang S, Feng L, Liu X, Ji Y, Tao L, Li S, Wei Y. Adv Healthc Mater, 2013, 2(2): 302 − 305 doi: 10.1002/adhm.201200166
78. [78]
  Li Y, Kumacheva E. Sci Adv, 2018, 4(4): eaas8998 doi: 10.1126/sciadv.aas8998
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