Citation: Hua Yue, Guang-hui Ma. Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines[J]. Acta Polymerica Sinica, ;2020, 51(2): 125-135. doi: 10.11777/j.issn1000-3304.2019.19143 shu

Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines

Hua Yue ,
Guang-hui Ma ^,

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190

Corresponding author: Guang-hui Ma, ghma@ipe.ac.cn
Received Date: 2 August 2019
Revised Date: 12 September 2019

With the increasing demand for preventing and controlling of new/sudden diseases, major infectious diseases and malignant tumors, vaccines that based on traditional experience await updated. In terms of the unique physio-chemical advantages, polymeric micro/nano particles have become the research hotspots in the field of biomedical delivery. However, the rational integration of the micro/nano particles into vaccine delivery system is a huge challenge. On the basis of our research on the preparation and application of polymer micro/nano particles, an advanced strategy that co-assembles the particle “chassis” and subunit vaccines into one engineered vaccine is proposed. During the 20-year systematic study, new functions of polymeric particles are developed, and important mechanisms for the enhanced cellular/mucosal immunity are clarified. Apart from the chassis with conventional physiochemical property, other chassises with lysosomal escape merit, unique properties (deformability or mobility), or “Immunoticket” advantage have been exploited. The present paper not only summarizes our work but also involves international research progress, which sheds light upon the engineered vaccine chassises for their on-demand design concept, relative mechanism and development.
- Polymer micro/Nano particles,
- Particle chassis,
- Engineered vaccine,
- Cellular immunity,
- Mucosal immunity
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