Citation: Zhi-peng Su, Meng-ting Tan, Yan-ling Cao, Yan Shi, Zhi-feng Fu. One-pot Preparation of Block Copolymer Nanoparticles byPolymerization-induced Self-assembly[J]. Acta Polymerica Sinica, ;2019, 50(8): 808-815. doi: 10.11777/j.issn1000-3304.2019.19026 shu

One-pot Preparation of Block Copolymer Nanoparticles byPolymerization-induced Self-assembly

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029

Corresponding author: Yan Shi, shiyan@mail.buct.edu.cn
Received Date: 31 January 2019
Revised Date: 11 March 2019
Available Online: 19 April 2019

Polymeric vesicles have important applications in biomedicine, nuclear magnetic imaging, nanoreactors, and catalyst fields. Amphiphiic block copolymer nanoparticles with different morphologies (such as vesicles and spheres), sizes and surface chemical properties have been successfully prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization-induced self-assembly (PISA). Generally, it is difficult for researchers to obtain pure vesicles with different sizes. In this study, we report an efficient approach to produce block copolymers vesicles by PISA. A one-pot, facile method for the synthesis of nano-objects composed of amphiphilic poly(4-vinylpyridine)-b-poly(4-vinylpyridine-r-styrene) block copolymer, P4VP-b-P(4VP-r-St), is introduced by P4VP trithiocarbonate macro-RAFT agent mediated dispersion copolymerization of 4VP and St in ethanol/water mixture. It is found that the morphology of P4VP-b-P(4VP-r-St) diblock copolymer nano-objects like spherical micelles, worms, and vesicles can be easily tuned either by changing the degree of polymerization of the random P(4VP-r-St) block, the amount of 4VP comonomer, solvent composition and the ratio of the degree of polymerization of PSt and P4VP segments. Among them, by adding a small amount of 4VP comonomer during the dispersion RAFT polymerization of St, the final morphology of the block copolymer can be greatly affected, pure vesicle can be formed and the size can be adjusted more effectively. Compared with the dispersion RAFT polymerization of St, the advantage of the dispersion RAFT copolymerization by utilizing residual solvophilic monomer to tune the block copolymer morphology is demonstrated. It is believed to be a novel, convenient and efficient protocol for the control of the morphology and size of the block copolymer nano-objects fabricated by PISA. The polymerization shows characteristic features of " living”/controlled radical polymerization and the experimental results are confirmed by gel permeation chromatography (GPC), dynamic light scattering (DLS), transmission electron microscopy (TEM) and ¹H-NMR. Due to diverse potential applications of polymer vesicles, the results of this study are of great importance for the theoretical design and application of PISA strategies.
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

One-pot Preparation of Block Copolymer Nanoparticles byPolymerization-induced Self-assembly

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com