Citation: Shu-quan Cui, Lin Yu, Jian-dong Ding. Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity[J]. Acta Polymerica Sinica, ;2018, 0(8): 997-1015. doi: 10.11777/j.issn1000-3304.2018.18084 shu

Injectable Thermogels Based on Block Copolymers of Appropriate Amphiphilicity

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438

Corresponding author: Jian-dong Ding, jdding1@fudan.edu.cn
Received Date: 29 March 2018
Revised Date: 27 May 2018
Available Online: 10 July 2018

Some amphiphilic copolymers in water can undergo a reversible sol-gel transition upon heating. If the transition temperature lies between room temperature and body temperature, the aqueous system can be readily mixed with drugs or cells at room temperature, and the mixture is injectable; the injected formulation is physically gelled at body temperature, and the gelation is free of any chemical crosslinking. This affords an amazing biomaterial type, yet many questions are open in light of fundamental research and potential clinical applications. In particular, block copolymers composed of hydrophilic poly(ethylene glycol) (PEG) and some hydrophobic biodegradable polyesters such as poly(lactide-co-glycolide) (PLGA) are of great clinical potential, yet of very unclear physical crosslinking points. This feature article summarizes the corresponding extensive investigations in the authors’ group led by Ding at Fudan University for a decade. The Ding group has found the significant effects of the end groups of the copolymer, molar mass dispersity Ð_M, and other molecular parameters on thermogellability, and revealed the corresponding rules of molecular design, based on their polymer chemistry studies. For instance, with increase in Ð_M under either given number average or weight average molecule weight, the sol-gel transition temperature for some block copolymer aqueous systems could shift unidirectionally, which indicates that the effect of molecular weight distribution could not be interpreted simply from addition of the effects of molecular weight or Ð_M affords an independent adjustable parameter. The Ding group has shed light on the mechanism of their thermogelling by putting forward the model of percolated micelle network to describe the internal structure of the physical hydrogel, and extended the range of the thermogellable molecular composition of the copolymers to a large extent by establishing a blend strategy, based on their polymer physics studies. The Ding group have also put forward many strategies for the clinical applications of the thermogels using animal models, including prevention of postoperative tissue adhesion, submucosal cushion for endoscopic submucosal dissection, sustained release carriers of antitumor drugs such as camptothecin derivatives, long-acting formulations of polypeptide drugs such as exenatide in treatment of type II diabetes, and tissue engineering of cartilage. The Ding group has also laid a material basis towards potential products of medical devices and drug carriers including the appropriate way of sterilization and improvement of the handling property of the synthesized polymers. The Ding group suggest some perspectives in the end of this feather article.
- Amphiphilic block copolymer,
- Physical hydrogel,
- Biomedical materials
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沈阳化工大学材料科学与工程学院沈阳 110142