Citation: Jin-feng Zeng, Wen-di Yang, Dong-jian Shi, Xiao-jie Li, Ming-qing Chen. Preparation and Photo-thermal Properties of Thermo-sensitive Injectable Hydrogels Based on Chitosan and Au Nanoparticles[J]. Acta Polymerica Sinica, ;2018, 0(10): 1297-1306. doi: 10.11777/j.issn1000-3304.2018.18048 shu

Preparation and Photo-thermal Properties of Thermo-sensitive Injectable Hydrogels Based on Chitosan and Au Nanoparticles

Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122

Corresponding author: Dong-jian Shi, djshi@jiangnan.edu.cn
Received Date: 5 February 2018
Revised Date: 28 March 2018
Available Online: 24 May 2018

Multiple injections of drugs are generally needed to continuously and effectively kill pathological cells during tumor therapeutic. However, this strategy might induce some side effects. Gold nanoparticles are one kind of photothermal agents that can convert the absorbed light energy into heat energy. This conversion could be used to photo-thermal therapy (PTT), which has property of multiple treatment for killing the tumor cells effectively and completely without other effects. Herein, this study aims to prepare injectable hydrogels with PTT property based on chitosan (CS), β-glycerophosphate (β-GP) and gold nanoparticles (Au NPs) for improving efficiency of anti-tumour. Firstly, CS bio-polymer stabilized Au NPs (CS-Au NPs) were directly reduced in situ by CS. Size of the CS-Au NPs could be controlled at 15 nm. Then, β-glycerophosphate (β-GP) was added into the CS-Au NPs. The mixture of CS-Au NPs and β-GP was sol state at room temperature, which could be injected into the tumor site. And then, at physiological temprature (37 °C), this sol could convert to gel (CGP/Au NPs) via the interactions between CS and β-GP, indicating that the (CGP/Au NPs) gel had the temperature sensitivity. Due to the surface plasmon resonance effect (SPR) of Au NPs, the (CGP/Au NPs) hydrogels showed an excellent photo-thermal property. The temperature of the (CGP/Au NPs) gel rised to above 45 °C and further to approximately 55 °C under Laser irradiation, with increasing amout of Au NPs. Moreover, the photo-thermal ability could be kept for several cycles with repeated laser irradiation. Because of easily fixing CGP hydrogels into biological tissue, Au NPs could be immobilized on the tumor site for a long time for multiple PTT. Thus, the strategies of muiliple drug-injection and blood circulation could be changed with the help of CGP hydrogels. Additionally, Au NPs were distributed evenly in the CGP hydrogels and the (CGP/Au NPs) hydrogels had good stability. Cell viability showed that the gels had excellent biocompatibility to the normal cells, and could kill remarkably the cancer cells with laser irradiation. Meanwhile, the prepared thermo-sensitive hydrogels had good biodegradability. Due to these characteristics, this (CGP/Au NPs) hydrogel might have the potential application to achieve " one time injection, multiple treatments” for tumor therapy.
- Thermo-sensitive hydrogels,
- Photo-thermal therapy,
- Gold nanoparticles
1. [1]
  Huang X, Jain P K, El-Sayed I H, El-Sayed M A. Lasers Med Sci, 2008, 23: 217 − 228
2. [2]
  Koo Y E, Reddy G R, Bhojani M, Schneider R, Philbert M A, Rehemtulla A, Ross B D, Kopelman R. Adv Drug Delivery Rev, 2006, 58: 1556 − 1577
3. [3]
  Abadeer N S, Murphy C J. J Phys Chem C, 2016, 120: 1171 − 1176
4. [4]
  Yan Gang
5. [5]
  Li S, Chen Y, Liu H, Wang Y, Liu L, Lv F, Li Y, Wang S. Chem Mater, 2017, 29: 6087 − 6094
6. [6]
  Li Y, Liu Z, Hou Y, Yang G, Fei X, Zhao H, Guo Y, Su C, Wang Z, Zhong H, Zhuang Z, Guo Z. ACS Appl Mater Interfaces, 2017, 9: 25098 − 25106
7. [7]
  Xing R, Liu K, Jiao T, Zhang N, Ma K, Zhang R, Zou Q, Ma G, Yan X. Adv Mater, 2016, 28: 3669 − 3676
8. [8]
  Han H S, Choi K Y, Lee H, Lee M, An J Y, Shin S, Kwon S, Lee D S, Park J H. ACS Nano, 2016, 10: 10858 − 10868
9. [9]
  Yuan Haijian
10. [10]
  Yang J, Yao M H, Jin R M, Zhao D H, Zhao Y D, Liu B. ACS Biomater Sci Eng, 2017, 3: 2391 − 2398
11. [11]
  Almada M, Leal-Martinez B H, Hassan N, Kogan M J, Burboa M G, Topete A, Valdez M A, Juarez J. Mat. Ssi. Eng C-Mater, 2017, 77: 583 − 593
12. [12]
  Wang C, Zhang H, Zeng D, San L, Mi X. Chin J Chem, 2016, 34: 299 − 307
13. [13]
  Jin Xintian
14. [14]
  Wang C, Wang X, Dong K, Luo J, Zhang Q, Cheng Y. Biomaterials, 2016, 104: 129 − 137
15. [15]
  Xu X, Huang Z, Huang Z, Zhang X, He S, Sun X, Shen Y, Yan M, Zhao C. ACS Appl Mater Interfaces, 2017, 9: 20361 − 20375
16. [16]
  Han L, Zhao J, Zhang X, Cao W, Hu X, Zou G, Duan X, Liang X J. ACS Nano, 2012, 6: 7340 − 7351
17. [17]
  Dang Q F, Zou S H, Chen X G, Liu C S, Li J J, Zhou X, Liu Y, Cheng X J. J Appl Polym Sci, 2012, 125: E88 − E98
18. [18]
  Dang Q F, Yan J Q, Li J J, Cheng X J, Liu C S, Chen X G. Carbohydr Polym, 2011, 83: 171 − 178
19. [19]
  Cao C, Yan C, Hu Z, Zhou S. Mol Med Rep, 2015, 12: 6688 − 6694
20. [20]
  Zeng Rong
21. [21]
  Liu H, Liu T, Wu X, Li L, Tan L, Chen D, Tang F. Adv Mater, 2012, 24: 755 − 761
22. [22]
  Khlebtsov N, Dykman L. Chem Soc Rev, 2011, 40: 1647 − 1671
23. [23]
  Jaque D, Martinez M L, del Rosal B, Haro-Gonzalez P, Benayas A, Plaza J L, Martin Rodriguez E, Garcia Sole J. Nanoscale, 2014, 6: 9494 − 9530
24. [24]
  Zeng J F, Yang W D, Shi D J, Li X J, Zhang H J, and Chen M Q. ACS Biomater Sci Eng, 2018, 4: 963 − 972
1. [1]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
2. [2]
  Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
3. [3]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
4. [4]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
5. [5]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254
6. [6]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
7. [7]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
8. [8]
  Yu Dai , Xueting Sun , Haoyu Wu , Naizhu Li , Guoe Cheng , Xiaojin Zhang , Fan Xia . Determination of the Michaelis Constant for Gold Nanozyme-Catalyzed Decomposition of Hydrogen Peroxide. University Chemistry, 2025, 40(5): 351-356. doi: 10.12461/PKU.DXHX202407052
9. [9]
  Yuena Yang , Xufang Hu , Yushan Liu , Yaya Kuang , Jian Ling , Qiue Cao , Chuanhua Zhou . The Realm of Smart Hydrogels. University Chemistry, 2024, 39(5): 172-183. doi: 10.3866/PKU.DXHX202310125
10. [10]
  Lina Liu , Xiaolan Wei , Jianqiang Hu . Exploration of Subject-Oriented Undergraduate Comprehensive Chemistry Experimental Teaching Based on the “STS Concept”: Taking the Experiment of Gold Nanoparticles as an Example. University Chemistry, 2024, 39(10): 337-343. doi: 10.12461/PKU.DXHX202405112
11. [11]
  Shiyang He , Dandan Chu , Zhixin Pang , Yuhang Du , Jiayi Wang , Yuhong Chen , Yumeng Su , Jianhua Qin , Xiangrong Pan , Zhan Zhou , Jingguo Li , Lufang Ma , Chaoliang Tan . 铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-. doi: 10.1016/j.actphy.2025.100046
12. [12]
  Kun Rong , Cuilian Wen , Jiansen Wen , Xiong Li , Qiugang Liao , Siqing Yan , Chao Xu , Xiaoliang Zhang , Baisheng Sa , Zhimei Sun . Hierarchical MoS₂/Ti₃C₂T_x heterostructure with excellent photothermal conversion performance for solar-driven vapor generation. Acta Physico-Chimica Sinica, 2025, 41(6): 100053-. doi: 10.1016/j.actphy.2025.100053
13. [13]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
14. [14]
  Laiying Zhang , Yinghuan Wu , Yazi Yu , Yecheng Xu , Haojie Zhang , Weitai Wu . Innovation and Practice of Polymer Chemistry Experiment Teaching for Non-Polymer Major Students of Chemistry: Taking the Synthesis, Solution Property, Optical Performance and Application of Thermo-Sensitive Polymers as an Example. University Chemistry, 2024, 39(4): 213-220. doi: 10.3866/PKU.DXHX202310126
15. [15]
  Tengjiao Wang , Tian Cheng , Rongjun Liu , Zeyi Wang , Yuxuan Qiao , An Wang , Peng Li . Conductive Hydrogel-based Flexible Electronic System: Innovative Experimental Design in Flexible Electronics. University Chemistry, 2024, 39(4): 286-295. doi: 10.3866/PKU.DXHX202309094
16. [16]
  Qiang Zhou , Pingping Zhu , Wei Shao , Wanqun Hu , Xuan Lei , Haiyang Yang . Innovative Experimental Teaching Design for 3D Printing High-Strength Hydrogel Experiments. University Chemistry, 2024, 39(6): 264-270. doi: 10.3866/PKU.DXHX202310064
17. [17]
  Qingyang Cui , Feng Yu , Zirun Wang , Bangkun Jin , Wanqun Hu , Wan Li . From Jelly to Soft Matter: Preparation and Properties-Exploring of Different Kinds of Hydrogels. University Chemistry, 2024, 39(9): 338-348. doi: 10.3866/PKU.DXHX202309046
18. [18]
  Xiufang Wang , Donglin Zhao , Kehua Zhang , Xiaojie Song . “Preparation of Carbon Nanotube/SnS₂ Photoanode Materials”: A Comprehensive University Chemistry Experiment. University Chemistry, 2024, 39(4): 157-162. doi: 10.3866/PKU.DXHX202308025
19. [19]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368
20. [20]
  Jun Huang , Pengfei Nie , Yongchao Lu , Jiayang Li , Yiwen Wang , Jianyun Liu . 丝光沸石负载自支撑氮掺杂多孔碳纳米纤维电容器及高效选择性去除硬度离子. Acta Physico-Chimica Sinica, 2025, 41(7): 100066-. doi: 10.1016/j.actphy.2025.100066

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(114)
HTML views(8)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142