Citation: Jing Fang, Wen-bin Zhang. Genetically Encoded Peptide-protein Reactive Pairs[J]. Acta Polymerica Sinica, ;2018, (4): 429-444. doi: 10.11777/j.issn1000-3304.2018.18034 shu

Genetically Encoded Peptide-protein Reactive Pairs

Jing Fang ,
Wen-bin Zhang ^,

Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871

Corresponding author: Wen-bin Zhang, wenbin@pku.edu.cn
Received Date: 1 February 2018
Revised Date: 22 February 2018

Chemical modification of proteins is of great significance in protein engineering, biomaterials, and chemical biology. Genetically encoded peptide-protein reactive pair, or "molecular superglue", refers to a peptide tag and its protein partner that can spontaneously reconstitute to form an isopeptide or ester bond between the side chains of specific residues of the two components. It is entirely based on natural amino acids and thus genetically encodable, providing a new way to do chemistry with proteins. This feature article summarizes the development of this unique set of chemical tools and elaborates on the principles and mechanisms of the isopeptide formation as well as the application of these tools in diverse fields. To date, a toolbox of peptide-protein reactive pairs has been developed and gradually gained its popularity in various fields such as protein topology engineering, protein-based biomaterials and protein nano-assemblies. Typical pairs include the isopeptide-bond-forming SpyTag/SpyCatcher, SnoopTag/SnoopCatcher, SdyTag/SdyCatcher etc. and the ester-bond-forming Cpe0147-A/Cpe0147-B. It allows the programming of post-translational modification of nascent proteins in vivo, which, in combination with protein folding, leads to versatile nonlinear protein topologies with unique properties, including circular proteins, star proteins, and protein catenanes. The protein catenation is found to enhance both the stability and the activity of the enzyme like dihydrofolate reductase. Their reactivity in vitro is also excellent. The covalent nature of SpyTag/SpyCatcher interaction has facilitated the processing of proteins into various materials forms including all-protein-based, chemically cross-linked hydrogels, functional layer-by-layer thin films, hybrid colloidal assemblies, and "living" materials. In this sense, they can serve as the "iron grip" to bring two parts together to form the conjugate, which may be helpful for diverse purposes such as the sortase activity enhancer. It also allows the preparation of protein nano-assemblies with ultra-high affinity, which are useful for applications like protein nanoreactors, synthetic vaccines, and protein therapeutics. The peptide-protein reactive pair technique thus opens new horizon in protein chemistry and paves the road to the synthesis and application of precision macromolecules with huge potential in real applications.
- SpyTag,
- SpyCatcher,
- Isopeptide,
- Protein engineering,
- Protein topology,
- Catenane
1. [1]
  Ober C K, Cheng S Z D, Hammond P T, Muthukumar M, Reichmains E, Wooley K L, Lodge T P. Macromolecules, 2009, 42:465-471 doi: 10.1021/ma802463z
2. [2]
  Frontiers in Polymer Science and Engineering, Report of a 2016 NSF Workshop. University of Minnesota, 2017
3. [3]
  Zhang W, Yu X, Wang C, Sun H, Hsieh I F, Li Y, Dong X, Yue K, van Horn R, Cheng S Z D. Macromolecules, 2014, 47:1221-1239 doi: 10.1021/ma401724p
4. [4]
  Tezuka Y, Oike H. J Am Chem Soc, 2001, 123:11570-11576 doi: 10.1021/ja0114409
5. [5]
  Dabrowski Tumanski P, Sulkowska J I. Proc Natl Acad Sci USA, 2017, 114:3415-3420 doi: 10.1073/pnas.1615862114
6. [6]
  Dabrowski Tumanski P, Sulkowska J. Polymers, 2017, 9:454 doi: 10.3390/polym9090454
7. [7]
  Xu L, Zhang W. Sci China Chem, 2018, 61:3-16 doi: 10.1007/s11426-017-9155-2
8. [8]
  Zhang G, Zheng S, Liu H, Chen P R. Chem Soc Rev, 2015, 44:3405-3417 doi: 10.1039/C4CS00393D
9. [9]
  Lim R K, Lin Q. Chem Commun, 2010, 46:1589-1600 doi: 10.1039/b925931g
10. [10]
  Schmidt M, Toplak A, Quaedflieg P J, Nuijens T. Curr Opin Chem Biol, 2017, 38:1-7
11. [11]
  Shah N H, Muir T W. Chem Sci, 2014, 5:446-461 doi: 10.1039/C3SC52951G
12. [12]
  Nguyen G K, Wang S, Qiu Y, Hemu X, Lian Y, Tam J P. Nat Chem Biol, 2014, 10:732-738 doi: 10.1038/nchembio.1586
13. [13]
  Parthasarathy R, Subramanian S, Boder E T. Bioconjug Chem, 2007, 18:469-476 doi: 10.1021/bc060339w
14. [14]
  Tsukiji S, Nagamune T. ChemBioChem, 2009, 10:787-798 doi: 10.1002/cbic.v10:5
15. [15]
  van Valkenburgh H A, Kahn R A. Method Enzymol, 2002, 344:186-193 doi: 10.1016/S0076-6879(02)44715-5
16. [16]
  Wang L, Brock A, Herberich B, Schultz P G. Science, 2001, 292:498 doi: 10.1126/science.1060077
17. [17]
  Reddington S C, Howarth M. Curr Opin Chem Biol, 2015, 29:94-99 doi: 10.1016/j.cbpa.2015.10.002
18. [18]
  Veggiani G, Zakeri B, Howarth M. Trends Biotechnol, 2014, 32:506-512 doi: 10.1016/j.tibtech.2014.08.001
19. [19]
  Zakeri B. ChemBioChem, 2015, 16:2277-2282 doi: 10.1002/cbic.v16.16
20. [20]
  Kang H J, Coulibaly F, Clow F, Proft T, Baker E N. Science, 2007, 318:1625-1628 doi: 10.1126/science.1145806
21. [21]
  Kang H J, Baker E N. Trends Biochem Sci, 2011, 36:229-237 doi: 10.1016/j.tibs.2010.09.007
22. [22]
  Wikoff W R, Liljas L, Duda R L, Tsuruta H, Hendrix R W, Johnson J E. Science, 2000, 289:2129-2133 doi: 10.1126/science.289.5487.2129
23. [23]
  Zakeri B, Howarth M. J Am Chem Soc, 2010, 132:4526-4527 doi: 10.1021/ja910795a
24. [24]
  Zakeri B, Fierer J O, Celik E, Chittock E C, Schwarz Linek U, Moy V T, Howarth M. Proc Natl Acad Sci USA, 2012, 109:E690-E697 doi: 10.1073/pnas.1115485109
25. [25]
  Zhang W, Sun F, Tirrell D A, Arnold F H. J Am Chem Soc, 2013, 135:13988-13997 doi: 10.1021/ja4076452
26. [26]
  Veggiani G, Nakamura T, Brenner M D, Gayet R V, Yan J, Robinson C V, Howarth M. Proc Natl Acad Sci USA, 2016, 113:1202-1207 doi: 10.1073/pnas.1519214113
27. [27]
  Li L, Fierer J O, Rapoport T A, Howarth M. J Mol Biol, 2014, 426:309-317 doi: 10.1016/j.jmb.2013.10.021
28. [28]
  Hagan R M, Bjornsson R, McMahon S A, Schomburg B, Braithwaite V, Buhl M, Naismith J H, Schwarz Linek U. Angew Chem Int Ed, 2010, 49:8421-8425 doi: 10.1002/anie.201004340
29. [29]
  Kolb H C, Finn M G, Sharpless K B. Angew Chem Int Ed, 2001, 40:2004-2021 doi: 10.1002/(ISSN)1521-3773
30. [30]
  Iha R K, Wooley K L, Nystrom A M, Burke D J, Kade M J, Hawker C J. Chem Rev, 2009, 109:5620-5686 doi: 10.1021/cr900138t
31. [31]
  McKay C S, Finn M G. Chem Biol, 2014, 21:1075-1101 doi: 10.1016/j.chembiol.2014.09.002
32. [32]
  Sun F, Zhang W. Chin Chem Lett, 2017, 28:2078-2084 doi: 10.1016/j.cclet.2017.08.052
33. [33]
  Zhang W, Wu X, Yin G, Shao Y, Cheng S Z D. Mater Horiz, 2017, 4:117-132 doi: 10.1039/C6MH00448B
34. [34]
  Barner Kowollik C, Du Prez F E, Espeel P, Hawker C J, Junkers T, Schlaad H, van Camp W. Angew Chem Int Ed, 2011, 50:60-62 doi: 10.1002/anie.v50.1
35. [35]
  Li Y, Wang Z, Zheng J, Su H, Lin F, Guo K, Feng X, Wesdemiotis C, Becker M L, Cheng S Z D, Zhang W. ACS Macro Lett, 2013, 2:1026-1032 doi: 10.1021/mz400519c
36. [36]
  Zimmer M. Chem Rev, 2002, 102:759-781 doi: 10.1021/cr010142r
37. [37]
  Tan L L, Hoon S S, Wong F T. PLoS ONE, 2016, 11:e0165074 doi: 10.1371/journal.pone.0165074
38. [38]
  Proschel M, Kraner M E, Horn A H C, Schafer L, Sonnewald U, Sticht H. PLoS ONE, 2017, 12:e0179740 doi: 10.1371/journal.pone.0179740
39. [39]
  Cao Y, Liu D, Zhang W. Chem Commun, 2017, 53:8830-8833 doi: 10.1039/C7CC04507G
40. [40]
  Habchi J, Tompa P, Longhi S, Uversky V N. Chem Rev, 2014, 114:6561-6588 doi: 10.1021/cr400514h
41. [41]
  Liu Y, Liu D, Yang W, Wu X, Lai L, Zhang W. Chem Sci, 2017, 8:6577-6582 doi: 10.1039/C7SC02686B
42. [42]
  Keeble A H, Banerjee A, Ferla M P, Reddington S C, Anuar I N A K, Howarth M. Angew Chem Int Ed, 2017, 56:16521-16525 doi: 10.1002/anie.201707623
43. [43]
  Kwon H, Squire C J, Young P G, Baker E N. Proc Natl Acad Sci USA, 2014, 111:1367-1372 doi: 10.1073/pnas.1316855111
44. [44]
  Young P G, Yosaatmadja Y, Harris P W, Leung I K, Baker E N, Squire C J. Chem Commun, 2017, 53:1502-1505 doi: 10.1039/C6CC09899A
45. [45]
  Fierer J O, Veggiani G, Howarth M. Proc Natl Acad Sci USA, 2014, 111:E1176-1181 doi: 10.1073/pnas.1315776111
46. [46]
  Siegmund V, Piater B, Zakeri B, Eichhorn T, Fischer F, Deutsch C, Becker S, Toleikis L, Hock B, Betz U A, Kolmar H. Sci Rep, 2016, 6:39291 doi: 10.1038/srep39291
47. [47]
  Kwon H, Young P G, Squire C J, Baker E N. Sci Rep, 2017, 7:42753 doi: 10.1038/srep42753
48. [48]
  Frisch H L, Wasserman E. J Am Chem Soc, 1961, 83:3789-3795 doi: 10.1021/ja01479a015
49. [49]
  Francl M. Nat Chem, 2009, 1:334-335 doi: 10.1038/nchem.302
50. [50]
  Forgan R S, Sauvage J P, Stoddart J F. Chem Rev, 2011, 111:5434-5464 doi: 10.1021/cr200034u
51. [51]
  Cascales L, Craik D J. Org Biomol Chem, 2010, 8:5035-5047 doi: 10.1039/c0ob00139b
52. [52]
  Schoene C, Fierer J O, Bennett S P, Howarth M. Angew Chem Int Ed, 2014, 53:6101-6104 doi: 10.1002/anie.201402519
53. [53]
  Schoene C, Bennett S P, Howarth M. Sci Rep, 2016, 6:21151 doi: 10.1038/srep21151
54. [54]
  Wang J, Wang Y, Wang X, Zhang D, Wu S, Zhang G. Biotechnol Biofuels, 2016, 9:79 doi: 10.1186/s13068-016-0490-5
55. [55]
  Si M, Xu Q, Jiang L, Huang H. PLoS ONE, 2016, 11:e0162318 doi: 10.1371/journal.pone.0162318
56. [56]
  Wang Y, Lin H, Chen L, Ding S, Lei Z, Liu D, Cao X, Liang H, Jiang Y, Tian Z. Chem Soc Rev, 2014, 43:399-411 doi: 10.1039/C3CS60212E
57. [57]
  Wang Y, Lin H, Ding S, Liu D, Chen L, Lei Z, Fan F, Tian Z. Sci China Chem, 2012, 42:525-547
58. [58]
  Danon J J, Krüger A, Leigh D A, Lemonnier J F, Stephens A J, Vitorica Yrezabal I J, Woltering S L. Science, 2017, 355:159 doi: 10.1126/science.aal1619
59. [59]
  Gil Ramirez G, Leigh D A, Stephens A J. Angew Chem Int Ed, 2015, 54:6110-6150 doi: 10.1002/anie.201411619
60. [60]
  Davison T S, Nie X, Ma W, Lin Y, Kay C, Benchimol S, Arrowsmith C H. J Mol Biol, 2001, 307:605-617 doi: 10.1006/jmbi.2001.4450
61. [61]
  Yan L Z, Dawson P E. Angew Chem Int Ed, 2001, 40:3625-3627 doi: 10.1002/1521-3773(20011001)40:19<3625::AID-ANIE3625>3.0.CO;2-Q
62. [62]
  Blankenship J W, Dawson P E. J Mol Biol, 2003, 327:537-548 doi: 10.1016/S0022-2836(03)00115-3
63. [63]
  Wang X, Zhang W. Angew Chem Int Ed, 2016, 128:3503-3507 doi: 10.1002/ange.201511640
64. [64]
  Wang X, Zhang W. Angew Chem Int Ed, 2017, 56:13985-13989 doi: 10.1002/anie.201705194
65. [65]
  Liu D, Wu W, Liu Y, Wu X, Cao Y, Song B, Li X, Zhang W. ACS Cent Sci, 2017, 3:473-481 doi: 10.1021/acscentsci.7b00104
66. [66]
  Lam S J, O'Brien Simpson N M, Pantarat N, Sulistio A, Wong E H H, Chen Y Y, Lenzo J C, Holden J A, Blencowe A, Reynolds E C, Qiao G G. Nat Microbiol, 2016, 1:16162 doi: 10.1038/nmicrobiol.2016.162
67. [67]
  Siegel J S. Science, 2004, 304:1256-1258 doi: 10.1126/science.1099216
68. [68]
  van Hest J C M, Tirrell D A. Chem Commun, 2001, 1897-1904
69. [69]
  Sun F, Zhang W, Mahdavi A, Arnold F H, Tirrell D A. Proc Natl Acad Sci USA, 2014, 111:11269-11274 doi: 10.1073/pnas.1401291111
70. [70]
  Gao X, Fang J, Xue B, Fu L, Li H. Biomacromolecules, 2016, 17:2812-2819 doi: 10.1021/acs.biomac.6b00566
71. [71]
  Gao X, Lyu S, Li H. Biomacromolecules, 2017, 18:3726-3732 doi: 10.1021/acs.biomac.7b01369
72. [72]
  Wang R, Yang Z, Luo J, Hsing I M, Sun F. Proc Natl Acad Sci USA, 2017, 114:5912-5917 doi: 10.1073/pnas.1621350114
73. [73]
  Zhou X, Chung H K, Lam A J, Lin M Z. Science, 2012, 338:810-814 doi: 10.1126/science.1226854
74. [74]
  Wu X, Huang W, Wu W, Xue B, Xiang D, Li Y, Qin M, Sun F, Wang W, Zhang W, Cao Y. Nano Res, 2018, DOI:10.1007/s12274-12017-11890-y doi: 10.1007/s12274-12017-11890-y
75. [75]
  Lyu S, Fang J, Duan T, Fu L, Liu J, Li H. Chem Commun, 2017, 53:13375-13378 doi: 10.1039/C7CC06991J
76. [76]
  Kou S, Yang Z, Sun F. ACS Appl Mater Interfaces, 2017, 9:2035-2039 doi: 10.1021/acsami.6b15968
77. [77]
  Kou S, Yang Z, Luo J, Sun F. Polym Chem, 2017, 8:6158-6164 doi: 10.1039/C7PY01206C
78. [78]
  Zhang X, Wang X, Da X, Shi Y, Liu C, Sun F, Yang S, Zhang W. Biomacromolecules, 2018, 19:DOI:10.1021/acs.biomac.1028b00190 doi: 10.1021/acs.biomac.1028b00190
79. [79]
  Obana M, Silverman B R, Tirrell D A. J Am Chem Soc, 2017, 139:14251-14256 doi: 10.1021/jacs.7b07798
80. [80]
  Chen A Y, Deng Z, Billings A N, Seker U O, Lu M Y, Citorik R J, Zakeri B, Lu T K. Nat Mater, 2014, 13:515-523 doi: 10.1038/nmat3912
81. [81]
  Nguyen P Q, Botyanszki Z, Tay P K, Joshi N S. Nat Commun, 2014, 5:4945 doi: 10.1038/ncomms5945
82. [82]
  Bai Y, Luo Q, Liu J. Chem Soc Rev, 2016, 45:2756-2767 doi: 10.1039/C6CS00004E
83. [83]
  Banerjee A, Howarth M. Curr Opin Biotechnol, 2017, 51:16-23
84. [84]
  Bedbrook C N, Kato M, Ravindra Kumar S, Lakshmanan A, Nath R D, Sun F, Sternberg P W, Arnold F H, Gradinaru V. Chem Biol, 2015, 22:1108-1121 doi: 10.1016/j.chembiol.2015.06.020
85. [85]
  Stranges P B, Palla M, Kalachikov S, Nivala J, Dorwart M, Trans A, Kumar S, Porel M, Chien M, Tao C, Morozova I, Li Z, Shi S, Aberra A, Arnold C, Yang A, Aguirre A, Harada E T, Korenblum D, Pollard J, Bhat A, Gremyachinskiy D, Bibillo A, Chen R, Davis R, Russo J J, Fuller C W, Roever S, Ju J, Church G M. Proc Natl Acad Sci USA, 2016, 113:E6749-E6756 doi: 10.1073/pnas.1608271113
86. [86]
  Wang H H, Altun B, Nwe K, Tsourkas A. Angew Chem Int Ed, 2017, 56:5349-5352 doi: 10.1002/anie.201701419
87. [87]
  Alam M K, Gonzalez C, Hill W, Fonge H, Barreto K, Geyer C R. ChemBioChem, 2017, 18:2217-2221 doi: 10.1002/cbic.201700411
88. [88]
  Giessen T W, Silver P A. ChemBioChem, 2016, 17:1931-1935 doi: 10.1002/cbic.v17.20
89. [89]
  Alves N J, Turner K B, Daniele M A, Oh E, Medintz I L, Walper S A. ACS Appl Mater Interfaces, 2015, 7:24963-24972 doi: 10.1021/acsami.5b08811
90. [90]
  Fairhead M, Veggiani G, Lever M, Yan J, Mesner D, Robinson C V, Dushek O, van der Merwe P A, Howarth M. J Am Chem Soc, 2014, 136:12355-12363 doi: 10.1021/ja505584f
91. [91]
  Liu Z, Zhou H, Wang W, Tan W, Fu Y X, Zhu M. Sci Rep, 2014, 4:7266
92. [92]
  Brune K D, Leneghan D B, Brian I J, Ishizuka A S, Bachmann M F, Draper S J, Biswas S, Howarth M. Sci Rep, 2016, 6:19234 doi: 10.1038/srep19234
93. [93]
  Thrane S, Janitzek C M, Matondo S, Resende M, Gustavsson T, de Jongh W A, Clemmensen S, Roeffen W, van de Vegte Bolmer M, van Gemert G J, Sauerwein R, Schiller J T, Nielsen M A, Theander T G, Salanti A, Sander A F. J Nanobiotechnol, 2016, 14:30 doi: 10.1186/s12951-016-0181-1
94. [94]
  Singh S K, Thrane S, Janitzek C M, Nielsen M A, Theander T G, Theisen M, Salanti A, Sander A F. Vaccine, 2017, 35:3726-3732 doi: 10.1016/j.vaccine.2017.05.054
95. [95]
  Janitzek C M, Matondo S, Thrane S, Nielsen M A, Kavishe R, Mwakalinga S B, Theander T G, Salanti A, Sander A F. Malar J, 2016, 15:545 doi: 10.1186/s12936-016-1574-1
96. [96]
  Leneghan D B, Miura K, Taylor I J, Li Y, Jin J, Brune K D, Bachmann M F, Howarth M, Long C A, Biswas S. Sci Rep, 2017, 7:3811 doi: 10.1038/s41598-017-03798-3
97. [97]
  Brune K D, Buldun C M, Li Y, Taylor I J, Brod F, Biswas S, Howarth M. Bioconjug Chem, 2017, 28:1544-1551 doi: 10.1021/acs.bioconjchem.7b00174
98. [98]
  Yumura K, Akiba H, Nagatoishi S, Kusano Arai O, Iwanari H, Hamakubo T, Tsumoto K. J Biochem, 2017, 162:203-210 doi: 10.1093/jb/mvx023
99. [99]
  Ham S, Min K A, Yang J W, Shin M C. Arch Pharm Res, 2017, 40:1094-1104 doi: 10.1007/s12272-017-0953-7
100. [100]
  Kasaraneni N, Chamoun Emanuelli A M, Wright G, Chen Z. mBio, 2017, 8:e01860-e01817
101. [101]
  Ke X, Zhang Y, Zheng F, Liu Y, Zheng Z, Xu Y, Wang H. Chem Commun, 2018, 54:1189-1192 doi: 10.1039/C7CC08880A
1. [1]
  Shuwen SUN , Gaofeng WANG . Two cadmium coordination polymers constructed by varying Ⅴ-shaped co-ligands: Syntheses, structures, and fluorescence properties. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 613-620. doi: 10.11862/CJIC.20230368
2. [2]
  Gaofeng WANG , Shuwen SUN , Yanfei ZHAO , Lixin MENG , Bohui WEI . Structural diversity and luminescence properties of three zinc coordination polymers based on bis(4-(1H-imidazol-1-yl)phenyl)methanone. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 849-856. doi: 10.11862/CJIC.20230479
3. [3]
  Lu LIU , Huijie WANG , Haitong WANG , Ying LI . Crystal structure of a two-dimensional Cd(Ⅱ) complex and its fluorescence recognition of p-nitrophenol, tetracycline, 2, 6-dichloro-4-nitroaniline. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1180-1188. doi: 10.11862/CJIC.20230489
4. [4]
  Xinyi Hong , Tailing Xue , Zhou Xu , Enrong Xie , Mingkai Wu , Qingqing Wang , Lina Wu . Non-Site-Specific Fluorescent Labeling of Proteins as a Chemical Biology Experiment. University Chemistry, 2024, 39(4): 351-360. doi: 10.3866/PKU.DXHX202310010
5. [5]
  Jin Tong , Shuyan Yu . Crystal Engineering for Supramolecular Chirality. University Chemistry, 2024, 39(3): 86-93. doi: 10.3866/PKU.DXHX202308113
6. [6]
  Xian BI , Sisi WANG , Jinyue ZHANG , Yujia PENG , Zhen SHEN , Hua LU . Discovery, development, and perspectives of circularly polarized luminescent materials based on β-isoindigo skeletons. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1049-1057. doi: 10.11862/CJIC.20240456
7. [7]
  Yifeng TAN , Ping CAO , Kai MA , Jingtong LI , Yuheng WANG . Synthesis of pentaerythritol tetra(2-ethylthylhexoate) catalyzed by h-MoO₃/SiO₂. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2155-2162. doi: 10.11862/CJIC.20240147
8. [8]
  Yurong Tang , Yunren Shi , Yi Xu , Bo Qin , Yanqin Xu , Yunfei Cai . Innovative Experiment and Course Transformation Practice of Visible-Light-Mediated Photocatalytic Synthesis of Isoquinolinone. University Chemistry, 2024, 39(5): 296-306. doi: 10.3866/PKU.DXHX202311087
9. [9]
  Hong RAO , Yang HU , Yicong MA , Chunxin LÜ , Wei ZHONG , Lihua DU . Synthesis and in vitro anticancer activity of phenanthroline-functionalized nitrogen heterocyclic carbene homo- and heterobimetallic silver/gold complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2429-2437. doi: 10.11862/CJIC.20240275
10. [10]
  Fangxuan Liu , Ziyan Liu , Guowei Zhou , Tingting Gao , Wenyu Liu , Bin Sun . Hollow structured photocatalysts. Acta Physico-Chimica Sinica, 2025, 41(7): 100071-. doi: 10.1016/j.actphy.2025.100071
11. [11]
  Dongheng WANG , Si LI , Shuangquan ZANG . Construction of chiral alkynyl silver chains and modulation of chiral optical properties. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 131-140. doi: 10.11862/CJIC.20240379
12. [12]
  Yan Liu , Yuexiang Zhu , Luhua Lai . Introduction to Blended and Small-Class Teaching in Structural Chemistry: Exploring the Structure and Properties of Crystals. University Chemistry, 2024, 39(3): 1-4. doi: 10.3866/PKU.DXHX202306084
13. [13]
  Qiuting Zhang , Fan Wu , Jin Liu , Zian Lin . Chromatographic Stationary Phase and Chiral Separation Using Frame Materials. University Chemistry, 2025, 40(4): 291-298. doi: 10.12461/PKU.DXHX202405174
14. [14]
  Zitong Chen , Zipei Su , Jiangfeng Qian . Aromatic Alkali Metal Reagents: Structures, Properties and Applications. University Chemistry, 2024, 39(8): 149-162. doi: 10.3866/PKU.DXHX202311054
15. [15]
  Wen-Bing Hu . Systematic Introduction of Polymer Chain Structures. University Chemistry, 2025, 40(4): 15-19. doi: 10.3866/PKU.DXHX202401014
16. [16]
  Jiarui Wu , Gengxin Wu , Yan Wang , Yingwei Yang . Crystal Engineering Based on Leaning Towerarenes. University Chemistry, 2024, 39(3): 58-62. doi: 10.3866/PKU.DXHX202304014
17. [17]
  Renxiao Liang , Zhe Zhong , Zhangling Jin , Lijuan Shi , Yixia Jia . A Palladium/Chiral Phosphoric Acid Relay Catalysis for the One-Pot Three-Step Synthesis of Chiral Tetrahydroquinoline. University Chemistry, 2024, 39(5): 209-217. doi: 10.3866/PKU.DXHX202311024
18. [18]
  Haiying Wang , Andrew C.-H. Sue . How to Visually Identify Homochiral Crystals. University Chemistry, 2024, 39(3): 78-85. doi: 10.3866/PKU.DXHX202309004
19. [19]
  Yumiao Gao , Yixin Chen , Jiaxin Wei , Junjie Yu , Yunxia Wang . Guarding the Kingdom: Skin Allies with Sunscreen for Mutual Protection. University Chemistry, 2024, 39(9): 74-80. doi: 10.12461/PKU.DXHX202404149
20. [20]
  Keying Qu , Jie Li , Ziqiu Lai , Kai Chen . Unveiling the Mystery of Chirality from Tartaric Acid. University Chemistry, 2024, 39(9): 369-378. doi: 10.12461/PKU.DXHX202310091

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(279)
HTML views(30)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142