Citation: Ying Wang, Jiaqi Lv, Song Liang, Yingdong Xie, Yuan Tian, Dong Li, Hong-Ying Zang. Molecular iron-oxo clusters ameliorate sepsis via enhancing humoral immune response[J]. Chinese Chemical Letters, ;2025, 36(11): 111455. doi: 10.1016/j.cclet.2025.111455 shu

Molecular iron-oxo clusters ameliorate sepsis via enhancing humoral immune response

Ying Wang ^{a, b, c, 1} ,
Jiaqi Lv ^{b, d, 1} ,
Song Liang ^e ,
Yingdong Xie ^a ,
Yuan Tian ^f ,
Dong Li ^{a, *,} ,
Hong-Ying Zang ^{b, *,}

a.
Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
b.
Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130022, China
c.
Department of Pharmacy, China-Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, China
d.
School of Chemistry and Environmental Engineering, Jilin Provincial Science and Technology Innovation Center of Optical Materials and Chemistry, Jilin Provincial International Joint Research Center of Photo functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, China
e.
Key Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, Changchun 130021, China
f.
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China

lidong1@jlu.edu.cn

zanghy100@nenu.edu.cn

Received Date: 3 April 2025
Revised Date: 10 June 2025
Accepted Date: 13 June 2025
Available Online: 13 June 2025

Figures(7)

Metal-based antimicrobial materials have been extensively studied and applied over decades. While these materials are notably characterized by their superior antibacterial performance and low propensity to induce drug resistance, critical limitations such as inherent cytotoxicity, poor solubility, and instability in aqueous solution remain significant challenges requiring systematic optimization. In this study, we synthesized water-soluble molecular iron-oxo clusters (MIC) with excellent biosafety and stability of aqueous solution. Our findings demonstrate that MIC exhibits marked therapeutic efficacy in cecal ligation and puncture induced sepsis models, a critical validation given sepsis' etiology as a life-threatening infection mediated systemic inflammatory syndrome. MIC combats bacteria by enhancing humoral immune responsiveness. MIC significantly improved the survival rate, reduced bacterial burden, stabilized body temperature, and modulated cytokine profiles in mice with sepsis. Further investigations revealed that MIC promotes B cells proliferation and oxidative phosphorylation, and mitigates mitochondrial damage and apoptosis in B cells, suggesting its role in modulating cellular metabolism. RNA sequencing analysis demonstrated that MIC exerts its effects by influencing key pathways involved in humoral immunity, inflammatory responses, and metabolic adaptation. These findings establish MIC as a novel therapeutic agent for regulating immune responses in sepsis, providing innovative strategies to improve recovery from this life-threatening condition.
- Sepsis,
- Molecular iron-oxo clusters,
- Immune modulation,
- Humoral immune response,
- Metal-based antibacterial materials
1. [1]
  T.P. Dasari, K. Pathakoti, H.M. Hwang, J. Environ. Sci. 25 (2013) 882–888.
2. [2]
  S. Ma, M. Zhang, J. Nie, et al., Carbohyd. Polym. 203 (2019) 415–422.
3. [3]
  Y. Zhong, X.T. Zheng, S. Zhao, X. Su, X.J. Loh, ACS Nano 16 (2022) 19840–19872. doi: 10.1021/acsnano.2c08262
4. [4]
  B.K. Gaiser, T.F. Fernandes, M. Jepson, et al., Environ. Health: A Global Access Sci. Source 8 (2009) S2. doi: 10.1186/1476-069X-8-S1-S2
5. [5]
  N. Hadrup, A.K. Sharma, N.R. Jacobsen, K. Loeschner, Drug Chem. Toxicol. 45 (2022) 2388–2397. doi: 10.1080/01480545.2021.1950167
6. [6]
  M. Singer, C.S. Deutschman, C.W. Seymour, et al., JAMA 315 (2016) 801–810. doi: 10.1001/jama.2016.0287
7. [7]
  L. Evans, A. Rhodes, W. Alhazzani, et al., Intensive Care Med. 47 (2021) 1181–1247. doi: 10.1007/s00134-021-06506-y
8. [8]
  L. Lu, L. Quan, J. Li, et al., J. Nanobiotechnol. 21 (2023) 170.
9. [9]
  T. van der Poll, F.L. van de Veerdonk, B.P. Scicluna, M.G. Netea, Nat. Rev. Immunol. 17 (2017) 407–420. doi: 10.1038/nri.2017.36
10. [10]
  T. van der Poll, M. Shankar-Hari, W.J. Wiersinga, Immunity 54 (2021) 2450–2464.
11. [11]
  B. Qiu, L. Cai, Y. Wang, et al., Mater. Today Energy 11 (2019) 89–96.
12. [12]
  J.Q. Lv, B. Li, Q. Liu, et al., Angew. Chem. Int. Ed. 62 (2023) e202306193.
13. [13]
  A. Shavel, B. Rodríguez-González, M. Spasova, M. Farle, L.M. Liz-Marzán, Adv. Funct. Mater. 17 (2007) 3870–3876. doi: 10.1002/adfm.200700494
14. [14]
  Z.M. Zhang, Y.G. Li, S. Yao, et al., Angew. Chem. Int. Ed. 48 (2009) 1581–1584. doi: 10.1002/anie.200805827
15. [15]
  D. Hu, H. Sheeja Prabhakaran, Y.Y. Zhang, et al., Critical Care 28 (2024) 292.
16. [16]
  Bushra, S.I.A., S. Begum, et al., Mitochondrion 79 (2024) 101967.
17. [17]
  M. Cao, G. Wang, J. Xie, Cell Death Discov. 9 (2023) 465.
18. [18]
  J.F. Bermejo-Martin, E.J. Giamarellos-Bourboulis, Int. J. Antimicrobial. Agents 46 (2015) S25–S28.
19. [19]
  K. Werdan, G. Pilz, O. Bujdoso, et al., Crit. Care Med. 35 (2007) 2693–2701.
20. [20]
  M. Akatsuka, Y. Masuda, H. Tatsumi, T. Sonoda, Clin Ther 44 (2022) 295–303.
21. [21]
  A. Bowen, M. Wear, A. Casadevall, Infection Immunity 85 (2017) e00202–00217.
22. [22]
  S. Paul, S.A. Planque, Y. Nishiyama, C.V. Hanson, R.J. Massey, Adv. Experim. Medicine Biol. 750 (2012) 56–75. doi: 10.1007/978-1-4614-3461-0_5
23. [23]
  M.J. Delano, P.A. Ward, J. Clinical Investigation 126 (2016) 23–31.
24. [24]
  D.C. Angus, S. Opal, Jama 315 (2016) 1457–1459. doi: 10.1001/jama.2016.2762
25. [25]
  J.D. Faix, Crit. Rev. Clin. Lab Sci. 50 (2013) 23–36. doi: 10.3109/10408363.2013.764490
26. [26]
  S. Preau, D. Vodovar, B. Jung, et al., Annal. Intensive Care 11 (2021) 104.
27. [27]
  D.L. Williams, C. Li, E.R. Sherwood, J. Leukoc Biol. 106 (2019) 7–9. doi: 10.1002/jlb.4ce0319-100r
28. [28]
  I. Grondman, R.J.W. Arts, R.M. Koch, et al., J. Leukoc Biol. 106 (2019) 11–25. doi: 10.1002/jlb.5hi0119-018r
29. [29]
  L.R. Waters, F.M. Ahsan, D.M. Wolf, O. Shirihai, M.A. Teitell, iScience 5 (2018) 99–109.
30. [30]
  O.T.M. Bucheli, D. Rodrigues, K. Portmann, et al., Sci. Rep. 14 (2024) 8507.
31. [31]
  N.M. Chapman, H. Chi, Immunity 55 (2022) 14–30.
32. [32]
  J. Chen, H. Wei, Front. Pharmacol. 12 (2021) 718089.
1. [1]
  Qiuxia Tan , E Pang , Qin Wang , Yuanyu Tang , Pan Zhu , Shaojing Zhao , Jianing Yi , Shiguang Jin , Minhuan Lan . Manganese carbonate-based nanoplatform for starvation therapy cascaded chemodynamic therapy, enhanced phototherapy and immune activation. Chinese Chemical Letters, 2025, 36(10): 110770-. doi: 10.1016/j.cclet.2024.110770
2. [2]
  Honghao Sun , Huimin Zhao , Ronghui Yin , Chenxi Zhou , Ming Wu , Yueyang Deng , Zhanwei Zhou , Minjie Sun . Injectable hydrogel-based tumor vaccine with fibrotic tumor immune microenvironment remodeling to prevent breast cancer postoperative recurrence and metastases. Chinese Chemical Letters, 2025, 36(5): 110067-. doi: 10.1016/j.cclet.2024.110067
3. [3]
  Hanyong Wang , Weijia Zhang , Chenlu Huang , Xinyu Yang , Qingyu Yu , Hai Wang , Wen Li , Linhua Zhang , Dunwan Zhu . Personalized tumor vaccines based on carrier-free double-adjuvant nanoparticles and tumor-associated antigens for enhancing immune responses. Chinese Chemical Letters, 2025, 36(7): 111092-. doi: 10.1016/j.cclet.2025.111092
4. [4]
  Yue Jin , Kun Dai , Lu Song , Xiaolei Zuo , Guangbao Yao , Min Li . Valence-programmed RNA origami for potent innate immune activation. Chinese Chemical Letters, 2025, 36(10): 110744-. doi: 10.1016/j.cclet.2024.110744
5. [5]
  Siyuan You , Rui Li , Haoyun Lu , Lifei Hou , Xing Xu , Yanan Shang . Modulation of the structures and properties of iron-carbon composites by different small molecular carbon sources for Fenton-like reactions. Chinese Chemical Letters, 2025, 36(9): 110955-. doi: 10.1016/j.cclet.2025.110955
6. [6]
  Run-Han Li , Tian-Yi Dang , Wei Guan , Jiang Liu , Ya-Qian Lan , Zhong-Min Su . Evolution exploration and structure prediction of Keggin-type group IVB metal-oxo clusters. Chinese Chemical Letters, 2024, 35(5): 108805-. doi: 10.1016/j.cclet.2023.108805
7. [7]
  Yuxin Tian , Mengjun Li , Yang Yang , Chunhui Li , Yun Peng , Haiyin Yang , Mengyuan Zhao , Pengfei Wu , Shaobo Ruan , Yuanyu Huang , Chenguang Shen , Minghui Yang . An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus. Chinese Chemical Letters, 2024, 35(8): 109270-. doi: 10.1016/j.cclet.2023.109270
8. [8]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
9. [9]
  Zhiqiang Cui , Dongxiang Zhang , Yanru Huang , Chunyu Shao , Yiming Zhang , Changliang Sun , Xin-Dong Jiang , Xiaohong Sun , Qinghuan Xiao . Novel 1-phenylethyl-containing aza-BDOIPY for phototherapy and simultaneous monitoring of tumor immune microenvironment reprogramming. Chinese Chemical Letters, 2025, 36(7): 110460-. doi: 10.1016/j.cclet.2024.110460
10. [10]
  Qian Wang , Dong Yang , Wenxing Xin , Yongqi Wang , Wenchang Han , Wengxiang Yan , Chunman Yang , Fei Wang , Yiyong Zhang , Ziyi Zhu , Xue Li . Modulation of desolvation barriers and inhibition of lithium dendrites based on lithophilic electrolyte additives for lithium metal anode. Chinese Chemical Letters, 2025, 36(6): 110669-. doi: 10.1016/j.cclet.2024.110669
11. [11]
  Fuyun Chi , Man Zhang , Yiman Han , Fukui Shen , Shijie Peng , Bo Su , Yuanyuan Hou , Gang Bai . Covalent modulation of mPGES1 activity via α,β-unsaturated aldehyde group: Implications for downregulating PGE2 expression and antipyretic response. Chinese Chemical Letters, 2025, 36(4): 109913-. doi: 10.1016/j.cclet.2024.109913
12. [12]
  Yaxin Sun , Huiyu Li , Shiquan Guo , Congju Li . Metal-based cathode catalysts for electrocatalytic ORR in microbial fuel cells: A review. Chinese Chemical Letters, 2024, 35(5): 109418-. doi: 10.1016/j.cclet.2023.109418
13. [13]
  Yatian Deng , Dao Wang , Jinglan Cheng , Yunkun Zhao , Zongbao Li , Chunyan Zang , Jian Li , Lichao Jia . A new popular transition metal-based catalyst: SmMn₂O₅ mullite-type oxide. Chinese Chemical Letters, 2024, 35(8): 109141-. doi: 10.1016/j.cclet.2023.109141
14. [14]
  Zhongchao Zhou , Jian Song , Yinghao Xie , Yuqian Ma , Hong Hu , Hui Li , Lei Zhang , Charles H. Lawrie . DFT calculation for organic semiconductor-based gas sensors: Sensing mechanism, dynamic response and sensing materials. Chinese Chemical Letters, 2025, 36(6): 110906-. doi: 10.1016/j.cclet.2025.110906
15. [15]
  Jun-Yi Wang , Jue-Yu Bao , Zheng-Guang Wu , Zheng-Yin Du , Xunwen Xiao , Xu-Feng Luo . Recent progress in steric modulation of MR-TADF materials and doping concentration independent OLEDs with narrowband emission. Chinese Journal of Structural Chemistry, 2025, 44(1): 100451-100451. doi: 10.1016/j.cjsc.2024.100451
16. [16]
  Hai-Ling Wang , Zhong-Hong Zhu , Hua-Hong Zou . Structure and assembly mechanism of high-nuclear lanthanide-oxo clusters. Chinese Journal of Structural Chemistry, 2024, 43(9): 100372-100372. doi: 10.1016/j.cjsc.2024.100372
17. [17]
  Yajie Yang , Mengde Zhai , Haoxin Wang , Cheng Chen , Ziyang Xia , Chengyang Liu , Yi Tian , Ming Cheng . Molecular engineering of dibenzo-heterocyclic core based hole-transporting materials for perovskite solar cells. Chinese Chemical Letters, 2025, 36(5): 110700-. doi: 10.1016/j.cclet.2024.110700
18. [18]
  Genlin Sun , Yachun Luo , Zhihong Yan , Hongdeng Qiu , Weiyang Tang . Chiral metal-organic frameworks-based materials for chromatographic enantioseparation. Chinese Chemical Letters, 2024, 35(12): 109787-. doi: 10.1016/j.cclet.2024.109787
19. [19]
  Xiaoxia WANG , Ya'nan GUO , Feng SU , Chun HAN , Long SUN . Synthesis, structure, and electrocatalytic oxygen reduction reaction properties of metal antimony-based chalcogenide clusters. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1201-1208. doi: 10.11862/CJIC.20230478
20. [20]
  Yunlong Li , Xinyu Zhang , Shuang Liu , Chunsheng Li , Qiang Wang , Jin Ye , Yong Lu , Jiating Xu . Engineered iron-based metal-organic frameworks nanoplatforms for cancer theranostics: A mini review. Chinese Chemical Letters, 2025, 36(2): 110501-. doi: 10.1016/j.cclet.2024.110501

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(21)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142