Citation: Qiong-Hui Peng, Ning-Bo Li, Jia-Cheng Hou, Cai-Jun He, Ya-Xin Yang, Chun-Lin Zhuang, Li-Juan Ou, Mei Yuan, Wei-Min He. Nd@g-C₃N₄ dual-functional photosynthesis and antitumor activities of 3-fluoroalkylated quinoxalin-2(1H)-ones[J]. Chinese Chemical Letters, ;2025, 36(12): 111402. doi: 10.1016/j.cclet.2025.111402 shu

Nd@g-C₃N₄ dual-functional photosynthesis and antitumor activities of 3-fluoroalkylated quinoxalin-2(1H)-ones

Qiong-Hui Peng ^{a, d} ,
Ning-Bo Li ^c ,
Jia-Cheng Hou ^{d, e} ,
Cai-Jun He ^a ,
Ya-Xin Yang ^a ,
Chun-Lin Zhuang ^d ,
Li-Juan Ou ^{b, *,} ,
Mei Yuan ^{a, *,} ,
Wei-Min He ^{d, *,}

a.
Department of Neurology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
b.
School of Materials Science and Engineering, Hunan Institute of Technology, Hengyang 421002, China
c.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
d.
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
e.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

oulijuanann@163.com

2012020002@usc.edu.cn

weiminhe@usc.edu.cn

Received Date: 22 April 2025
Revised Date: 29 May 2025
Accepted Date: 30 May 2025
Available Online: 31 May 2025

Figures(8)

Herein, the Nd@g-C₃N₄ dual-functional photocatalysis enabled fluoroalkylative heteroarylation of alkenes with R_fSO₂Cl under visible-light and ultrasound conditions was firstly reported. The photogenerated electron-driven reductive production of fluoroalkyl radical paired with photogenerated hole-driven oxidative production of chloride radical resulted in the full utilization of photogenerated carrier for bond formation. A wide range of N-heteroarenes, alkenes and R_fSO₂Cl, were well compatible for this reaction to access valuable fluoroalkylated N-heteroarenes with diverse structural features. The antitumor potential of synthesized fluoroalkylated N-heterocycles against Glioma 261 cells was evaluated by CCK8 assay. Notably, compound 4aka demonstrated remarkable efficacy, exhibiting approximately sevenfold greater potency than temozolomide, a widely used chemotherapeutic agent.
- Dual-functional photocatalysis,
- Dual role,
- Quinoxalin-2(1H)-one,
- Fluoroalkylatione, Photogenerated carrier
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Nd@g-C3N4 dual-functional photosynthesis and antitumor activities of 3-fluoroalkylated quinoxalin-2(1H)-ones

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通讯作者: 陈斌, bchen63@163.com

Nd@g-C₃N₄ dual-functional photosynthesis and antitumor activities of 3-fluoroalkylated quinoxalin-2(1H)-ones